SCIENTIFIC PROGRAM 5th WORLD BIOMATERIALS CONGRESS Toronto, Canada May 28-June 2, 1996 D.C. Smith, President J.L. Brash, J.M. Lee, Scientific Co-chairs ___________________________________________________________ Thursday, May 30 : Plenary Session 8:30-10:00 Grand Ballroom 8:30 Welcoming Remarks Chair: Dennis Smith, Congress President 9:00 Plenary Lecture Judah Folkmann Department of Surgery, Children's Hospital, Boston, U.S.A. Angiogenesis in Tissue Engineering Chair: J.L. Brash ___________________________________________________________ Thursday, May 30 : Oral Session 1 10:30-12:00 BIOGLASS Room 206A/B Chairs: L. Hench, C.Y. Kim 10:30 I-1. Bioactive Glass Particles of Narrow Size Range for In-Vivo Bone Tissue Engineering. Schepers E., Ducheyne P., University of Leuven, Department of Prosthetic Dentistry, Leuven, Belgium. 10:45 I-2. Particulate Bioglass Stimulates IL-1a and TNFa Secretion in Human Synoviocytes. Bendall S.P., Gaies M.G., Frondoza C., Jinnah R.H., Hungerford D.S., John Hopkins University, Department of Orthopaedic Surgery, Baltimore, USA. 11:00 I-3. Glass-Ceramics of the 3CaO¥P2O5- MgO¥SiO2 Pseudo-Binary. Fernandes M., Correia R., Oliveira J., University of Aveiro, Dept. of Ceramics and Glass Eng., Aveiro, Portugal. 11:15 I-4. Injectable Bioglass for Soft Tissue Augmentation: (Part 2) Comparison with Collagen. Wilson J., Proctor D.C., Elsberg L., Brownlee R.E., Bioglass Research Center, Alachua, USA. 11:30 I-5. Solution Effects on the Structure and Composition of Bioactive Glass Reaction Surfaces. Radin S., Ducheyne P., Conti A., University of Pennsylvania, Department of Bioengineering, Philadelphia, USA. 11:45 I-6. In-Vitro Hydroxyapatite Formation on Bioactive Glasses. Greenspan D.C., Zhong J.P., Lobel K.D., US Biomaterials Corporation, Alachua, USA. Biocompatibility I Room 206C/D Chairs: A. Hoffman, R. Albrecht 10:30 I-7. Evaluation of Inflammatory Cell Activation Induced by Polymeric Materials Using a Rodent Air-Pouch Model. Hooper R.M., Nickolas T.L., Macon N.D., Laskin D.L., Kohn J., Rutgers University, Department of Chemistry, Piscataway, USA. 10:45 I-8. Evaluation of a New Tissue Sealant Material: Serum Albumin Crosslinked In-Vivo With Polyethylene Glycol. Barrows T.H., Truong M.T., Grussing D.M., Kato K.H., Gysbers J.E., Lamprecht E.G., 3M Center, Life Sciences Sector Laboratory, St. Paul, USA. 11:00 I-9. Molecular Determinants of Acute Inflammatory Responses to Biomaterials. Tang L., Ugarova T.P., Plow E.F., Eaton J.W., Albany Medical College, Division of Experimental Pathology, Albany, USA. 11:15 I-10. Tissue Reactions and Sensitization of Chromium, Titanium and Zirconium Alloys. Ikarashi Y., Tsuchiya T., Nakamura A., Toyoda K., Takahashi M., Doi H., Kobayashi E., National Institute of Health, Sciences, Tokyo, Japan. 11:30 I-11. Cytotoxicity of Ceramic and Polyethylene By Flow Cytometry. Catelas I., Yahia L.H., Huk O., Marchand R., Ecole Polytechnique, Biomedical Engineering Institute, Montreal, Canada. 11:45 I-12. Evaluation of Angiogenesis: A Correlative Microscopic Approach. Albrecht R.M., Steeber D.A., Sims P.A., University of Wisconsin, Madison, USA. THROMBOGENICITY Room 206E/F Chairs: C. Baquey, R. Eberhart 10:30 I-13. Peptide Modified Gold Coated Polyurethanes for Thrombin Inhibition. Sheardown H., Brash J.L., McMaster University, Department of Chemical Engineering, Hamilton, Canada. 10:45 I-14. Immobilization of Human Thrombomodulin onto Biomaterials. Akashi M., Kishida A., Akatsuka Y., Fujinaga H., Ueno Y., Maruyama I., Kagoshima University, Faculty of Engineering, Kagoshima, Japan. 11:00 I-15. Immobilization of Theophylline on Medical-Grade Polyurethane Inhibits Surface- Induced Activation of Blood Platelets. Koole L.H., Kuijpens J.M.H., Kardaun G.A., Blezer R., Pijpers A.P., BIOPRIME, Maastricht, Netherlands. 11:15 I-16. Photo-Immobilization of Dipyridamole Decreases Thrombogenicity of Polyurethane Surfaces. Aldenhoff Y.B.J., Koole L.H., BIOPRIME, Maastricht, Netherlands. 11:30 I-17. Composite Tissue Adhesive as a Hemostatic Agent for Parenchymatous Trauma. Wilson D.J., Kloss J.M., Prior J.J., Sierra D.H., Terris D.J., Cohesion Corporation, Palo Alto, USA. 11:45 I-18. Quantitative Analysis of Complement Protein Adsorption: C3b Breakdown Products and sC5b-9 on Biomaterials. Gemmell C., Sefton M.V., Toronto Hospital, Department of Medicine, Toronto, Canada. CELL/SURFACE INTERACTIONS I Room 104A/B Chairs: P. Thomsen, H. Hlady 10:30 I-19. Gene Expression on Surfaces of Well- Controlled Chemistry. McClary K., Grainger D.W., Colorado State University, Department of Biochemistry and, Molecular Biology, Fort Collins, USA. 10:45 I-20. Morphology Orientation and Attachment of Fibroblasts on Silicone Surfaces with Micro-Grooves. den Braber E., de Ruijter J., Croes H., Ginsel L., von Recum A., Jansen J., University of Nijmegen, Dept. of Cell Biology and Histology, Lab. of Biomaterials, Nijmegen, Netherlands. 11:00 I-21. Cell Interactions with Modified Fluoropolymer Surfaces. Martin A., Johansson A., Rindlav A., Hjertberg T., Thomsen P., Institute of Anatomy & Cell Biology, Goteborg, Sweden. 11:15 I-22. Cell Attachment to Protein-Treated Glass Surfaces with Terminal Thiol and Sulfonate Groups. Webb K., Hlady V., Tresco P.A., University of Utah, Department of Bioengineering, Tissue Engineering Laboratory, Salt Lake City, USA. 11:30 I-23. Surface Topography and Attachment Factors in Epithelial Adhesion. Beumer G.J., Fitton J.H., Johnson G., Griesser H.J., Steele J.G., CSIRO, Division of Chemicals and Polymers, Clayton, Australia. 11:45 I-24. Endothelial Cell Growth and Serum Protein Adsorption: Effect of Surface Chemistry as Assessed with Self Assembled Monolayers. Tidwell C., Ratner B.D., Tarasevich B., Atre S., Allara D.L., University of Washington, Center for Bioengineering, Seattle, USA. DRUG DELIVERY I Room 104C Chairs: J. Feijen, S. Shalaby 10:30 I-25. Continuous Delivery of Analgesics by Ceramics. Bajpai P.K., Moldovan K.M., University of Dayton, Department of Biology, Dayton, USA. 10:45 I-26. pH-Sensitive Enzyme Release from Polymer Gel with Phosphate Groups. Nakamae K., Nishino T., Furukawa M., Nizuka T., Kanzaki Y., Hoffman A.S., Yamanaka A., Kobe University, Faculty of Engineering, Dept. Chemical Science & Engineering, Kobe, Japan. 11:00 I-27. The Effect of Acidic Fibroblast Growth Factor (FGF -1) Delivered Through a Porous Fibrin Scaffold on Meshed Skin Grafts. Blum B., Osborne S.W., Feldman D., Kelpke S., Pandit A., Thompson J.A., University of Alabama, Department of Biomedical, Engineering, Birmingham, USA. 11:15 I-28. Iontophoretic Controlled Delivery of Modified Insulin. Corbett J.T., Dooley R.L., Michniak B.B., Zimmerman J.K., Shalaby S.W., Clemson University, College of Engineering and Sciences, Clemson, USA. 11:30 I-29. TCPL Delivery System: The Effect of Various Testosterone Concentrations Using Adult Castrated Rams. Benghuzzi H.A., England B.G., University of Mississippi Medical Center, Department of Orthopaedics, Jackson, USA. 11:45 I-30. Design of pH-Responsive Polyamine Graft Copolymers for Application to Novel Polynucleotide Carriers. Asayama S., Maruyama A., Akaike T., Tokyo Institute of Technology, Dept. of Biomolecular Engineering, Faculty of Bioscience & Technology, Yokohama-shi, Japan. OrthopAEdics I Room 104D Chairs: H. Alexander, P. Tranquilli-Leali 10:30 I-31. Interleukin-1b ÊConcentrations in Total Knee Arthroplasty. Kovacik M.W., Gradisar I.A., Sylvester A.M., Haprian J.J., Alexander T.S., Summa Health Systems, Department of Orthopaedic Surgery, Arkon, USA. 10:45 I-32. Treatment of Large Diaphyseal Bone Defects Using Polyactide Membrane in Combination with Autogenic Cancellous Bone. Gerber A., Gogolewski S., University of Berne, Department of Orthopaedic Surgery, Winterthur, Switzerland. 11:00 I-33. Distinct Inflammatory Effect of TGF-a in Aseptic Loosening of TJR. AL Saffar N., Khwaja H., Revell P.A., Royal Free Hosp. School of Medicine, IRC in Biomedical Materials, Department of Histopathology, London, UK. 11:15 I-34. Laser-Induced Autofluorescence of Intact Articular Cartilage. Kovach I.S., Richards-Kortum R., Athanasiou K.A., University of Texas, Health Science Center, San Antonio, USA. 11:30 I-35. First Clinical Results with PEO/PBT Bone Substitute. Bakker D., Bulstra S.K., HC Implants B.V., Leiden, Netherlands. 11:45 I-36. Evaluation of Collagraft in an Ovine Lumbar Fusion Model Using Dual Energy X- Ray Absorptiometry (DEXA). Walsh W.R., Loefler A., Harrison J., Martin T., Sonnabend D.H., University of New South Wales, Prince of Wales Hospital, Traumatic & Orthopaedic Surgery, Randwick, Australia. ___________________________________________________________ Thursday, May 30: Poster Session I: 8:30-10:00 ADHESIVES AND CEMENTS II-37. Effect Of Cross Linking Agents On Poly(Methylmethacrylate) Bone Cements. Deb S., Vazquez B., Bonfield W., University of London, Queen Mary & Westfield College, IRC in Biomedical Materials, London, UK. II-38. Effect of Environmental Conditions of Fatigue Crack Propagation In Acrylic Bone Cements. Ginebra M.P., Vandroy Y., Gil F.X., San Roman J., Vazquez B., Levenfeld B., Goni I., ETSEIB University Politecnica de, Catalunya, Department Materials Science, Barcelona, Spain. II-39. Bone Cement Porosity and Volume are Affected by Chemicals Used During Specimen Processing. Harman M.K., Banks S.A., Hodge W.A., Good Samaritan Medical Center, Orthopaedic Research Lab., West Palm Beach, USA. II-40. Laser Ablation of Dyed Acrylic Bone Cement. Litsky A.S., Lee C.L., Roberts C.J., Ohio State University, Orthopaedic BioMaterials Laboratory, Columbus, USA. II-41. The Use of Molded Notches to Study Fatigue Crack Initiation in PMMA Bone Cement. Lu X., Topoleski L.D.T., University of Maryland, Department of Mechanical Engineering, Baltimore, USA. II-42. Development of a New Bioactive Bone Cement Available To Fix Implants. Nakamura T., Tamura J., Senaha Y., Matsuda T., Ido K., Kawanabe K., Fujita H., Kyoto University, Kyoto, Japan. II-43. Poly Ether Ketone Ether Ketone Ketone (PEKEKK) As a Thermoplastic Adhesive in Metal-To-Metal Joints for Structural Orthopedic Applications. Ramani K., Tagle J., Weidner W., Devanathan D., Purdue University, School of Mechanical Engineering, West Lafayette, USA II-44. The Development of a New Bioactive Cement. Saito M., Shibuya T., Murakami A., Hino K., Nakashima T., Ochi T., Osaka Koseinenkin Hospital, Department of Orthopaedic Surgery, Osaka, Japan. II-45. The Effects of Initial Component Temperature on the Flow Properties and Set-Up Time of PMMA Bone Cement. Sullivan S.J.L., Topoleski L.D.T., University of Maryland, Department of Mechanical Engineering, Baltimore, USA. II-46. Gamma Irradiation on the PMMA Precoat Interfacial Strength. Wallace S.A., Zimmer Inc., Warsaw, USA. BIOCERAMICS II-47. Characterization of Differently Prepared Apatites Revealed by Albumin Adsorption Behavior. Akazawa T., Kobayashi M., Hokkaido Industrial Research Institute, Sapporo, Japan. [*Withdrawn*] II-48. The Resorption of a Bioactive Glass Implanted Into Rat Soft Tissue. Brink M., Yli-Urpo S., Yli-Urpo A., Abo Akademi University, Department of Chemical Engineering, Turku, Finland. II-49. Calcium Hudroxylapatite Ceramic Particulate Integrity in Soft Tissue. Devine T.R., Reese L.A., ConvaTec, Racine, USA. II-50. Chemical Mechanism of Fluorapatite Dissolution. Dorozhkin S.V., Research Institute of Fertilizers, Moscow, Russia. II-51. Histological Evaluation of Plasma Sprayed Bioactive Glass Coatings on Titanium. Helsen J.A., Schepers E., Schrooten J., Brauns E., Catholic University of Leuven, Department of Metallurgy and Materials Engineering, Leuven, Belgium. II-52. Implantation Of Hydroxyapatite-Bonded Polymer. Ikada Y., Kamei S., Kato K., Tomita N., Tamai S., Kyoto University, Research Center for Biomedical Engineering, Kyoto, Japan. II-53. Preparation of Macroporous Hydroxyapatite Ceramics. Kim S.S., Lee J., Yeungnam University, Department of Materials Science and Engineering, Kyongbuk, Korea. II-54. Comparative In Vitro Reactivity of Bioactive Materials. LeGeros R., Bautista C., Pilet P.N., Retino M., LeGeros J.P., New York University, College of Dentistry, New York, USA. II-55. Apatite Crystals With Soluble Surface and Less Soluble Core. Okazaki M., Tohda M., Yanagisawa T., Taira M., Takahashi J., Osaka University, Department of Dental Technology, Faculty of Dentistry, Osaka, Japan. II-56. The Effect of Microstructure on Bioresponse of Calcium Phosphate Ceramics. Qu S., Chen W., Yang Z., Zhang X., Sichuan University, Institute of Materials Science and Technology, Chengdu, China. II-57. Surface Development of Bioglass Exposed to Culture Medium in the Presence or Absence of Proteins and Bone Derived Cells. Shelton R., Mei J., Marquis P.M., University of Birmingham, School of Dentistry, Biomaterials Unit, Birmingham, UK. II-58. Fracture Toughness of Hydroxyapatite Reinforced With P2O5-CaO Glasses Containing Na2O K2O and MgO. Silva P.L., Santos J.D., Knowles J.C., Silva R.F., Monteiro F.J., INEB Institute de Engenharia, Biomedica Praca, Porto, Portugal. II-59. Factors Affecting Bonding Rate of Calcium Phosphate Ceramic Coatings for In Vivo Strain Gage Attachment. Szivek J.A., Anderson P.L., Dishongh T.J., De Young D.W., University of Arizona, Orto. Research Lab Dept of Surgery, College of Medicine, Tucson, USA II-60. Non Stoichiometry in Calcium Hydroxyapatites Determined from their Calcination Products by the Rietveld Method. Vallet-Regi M., Rodriguez L., Salinas A., Dpto. de Quimica Inorganica, Fac. de Farmacia, Madrid, Spain. BIOCOMPATIBILITY II-61. Histological Evaluation of Two Bioactive Cements. Cavalheiro J., Vasconcelos M., Afonso A., Branco R., Planell J., Driessens F., INEB-Inst. Eng. Biomedica-Praca, Porto, Portugal. II-62. A Biological Investigation of Skeletal Aluminum Accumulation in Mice of Different Ages. Grew J.C., Blumenthal N.C., Betts F., Tonna E.A., Jersey State College, Department of Biology, Jersey City, USA. II-63. In Vitro Biocompatibility Testing of Degradable Polymers. Gurav N., Kayser M.V., Downes S., University of Nottingham, Queen's Medical Centre, Department of Human Morphology, Nottingham, UK. II-64. Biocompatibility of Silicon and Polyethylene Membranes - A Comparable Study on Three Pediatric Membrane Oxygenators. Heller W., Wendel H.P., University of Tubingen, Department of Cardiovascular Surgery, Tubingen, Germany. II-65. A Histological and Mechanical Evaluation of the Effect of Ca-P Cement on Bone Apposition. Jansen J.A., Wolke J.G.C., Hayakawa T., Planell J.A., Driessens F.C.M., University of Nijmegen, Department of Oral Function, Dental School, Nijmegen, Netherlands. II-66. Evidence for Stimulation of T Lymphocytes by Interleukin 15 in the Implant Interface Membrane. Jellie S., Folefac V., Osei D., Yamac T., Revell P., Royal Free Hosp. School of Medicine, IRC in Biomedical Materials, Department of Histopathology, London, UK II-67. The Binding of Adhesive Proteins to Material Surfaces. Kothari S., Douglas C.W.I., James P.F., Hatton P.V., University of Sheffield, Department of Restorative Dentistry, School of Clinical Dentistry, Sheffield, UK. II-68. Examination of Hydroxyapatite Filled 4 Meta/ MMA-TB B Adhesive Bone Cement In Vitro and in In Vivo Enviroments. Lee R.R., Ogiso M., Watanabe A., Nakabayashi N., Tokyo Medical & Dental University, Division of Organic Materials, Kanda, Japan. II-69. A Novel In Vitro Model to Study the Calcification Ability of Biomaterials. Liu Q., Weng J., de Wijn J.R., van Blitterswijk C.A., Leiden University, Biomaterials Research Group, Bilthoven, Netherlands. II-70. Biological Evaluation For Three Kinds of Hydroxyapatite (HA) Layer Sprayed by Different Coating Methods. Oguchi H., Mizoue K., Karbe Y., Seto K., Hastings G., Tsurumi University, School of Dental Medicine, 1st Dept. Oral & Maxillofac. Surg., Yokohama, Japan II-71. Mapping of Elemental Distribution in Organic Tissues Around Titanium Alloy Implants. Otsuka T., Ektessabi A., Honda S., Tsuboi Y., Horino Y., Mokuno Y., FujII K., Kyoto University, Faculty of Engineering, Kyoto, Japan. II-72. Study of Alginate Films for Wound Dresssing Applications. Sartori C., Finch D.S., Ralph B., Gilding K., Brunel University, Department of Materials Technology, Uxbridge, UK. II-73. In Vitro Analysis of Mechanical Properties of a New Tissue Sealant Material: Polyethylene Glycol Crosslinked Serum Albumin. Truong M.T., Barrows T.H., Wilson T.J., 3M Center, Life Sciences Sector Laboratory, St. Paul, USA. II-74. Modulation of the Tissue Reaction to Biomaterials. van Luyn M.J.A., van Wachem P.B., Blaauw E.H., van Rooyen N., University of Groningen, Laboratory for Cell Biology and Electron Microscopy, Groningen, Netherlands. II-75. In Vitro Model To Study Epithelial Response To Implants. Young A., MacNeil S., Brook I.M., University of Sheffield, Department of Oral and Medicine SCD, Sheffield, UK. BIOMECHANICS II-76. The Comparison Study of Bone Interface of Apatite/Alumina Biocomposites and Titanium. Zhixiong Y., Shaoxian Z., Guiju L., Yuan L., Changzong T., Bisheng C., Chinese Academy of Sciences, Shanghai Institute of Ceramics, Shanghai, China. II-77. Varus/Valgus Constraint Levels Of Revision Total Knee Systems. Cournoyer J., Kennedy J.W., Sommerich R.E., Johnson & Johnson Professional Inc., Raynham, USA. II-78. Strain Gage Analysis of an Anatomical Short Stem Prosthesis: An In Vitro Strain Gage Study. Fagan M., Bushelow M., Pipino F., Howmedica Inc., Division of Pfizer Hospital, Products Group, Rutherford, USA. II-79. A Non-Linear Finite Element Analysis of a Modular Stem Assembly. Kelly W.J., Elbert K.E.K., Bushelow M., Bonicel Y., Howmedica Inc., Division of Pfizer Hospital, Products Group, Rutherford, USA. II-80. An Innovative Method for Analyzing Fatigue Failure of Tibial Baseplates. Krevolin J., Goodman M., Asquith J., Bristol R., Intermedics Orthopedics Inc., Austin, USA. II-81. Mechanical Evaluation of Explanted Hip Prostheses: Technique and First Results. Labey L., Gross U., Boyde A., Hahn M., Merolli A., Meunier A., Revell P.A., Universite Leuven, Heverlee, Belgium. II-82. Mechanical Performance of a Hybrid Composite Hip Stem in a Lipid Environment: Residual Strength and Microscopic Analysis After Fatigue Cycling. Marcolongo M.S., Trentacosta J.D., Hastings R.S., DePuy DuPont Orthopaedics, Newark, USA. II-83. Dynamic Mechanical Behaviour Of Modified Hydroxyapatite Reinforced Polyethylene Composites. Nazhat S.N., Smith R., Deb S., Wang M., Tanner K.E., Bonfield W., University of London, Queen Mary & Westfield College, IRC In Biomedical Materials, London, UK II-84. Deformation at the Nanometer Level in Cortical Bone Using Small Angle X-Ray Scattering. Orr T.E., Baugh L., Bellare A., VA Medical Center, Rehabilitation Engineering R & D, Roxbury, USA. II-85. Evaluation of Impact-Induced Cartilage Damage by Means of a Histologic Dye. Schroeder C.F., Bidez M.W., Lucas L.C., University of Alabama, Department of Biomedical Engineering, Birmingham, USA. II-86. Effect of Varying Morse Taper Sleeve Thickness on the Micromotion. Shareef N.H., Levine D., Lin S., Tanamal L., Zimmer Inc., Warsaw, USA. II-87. Axial and Rotational Subsidence of Hip Stems in a Composite Femur Model: Differences Between Four Press-Fit Designs and Cemented Fixation. Smith W.P., Dawson J., Chenger J., Quigley B., Vanderbilt University, Department of Orthopaedics, and Rehabitation, Nashville, USA II-88. Stress Reduction By Ti-Ni Alloy In Impact Compression Test. Yoneyama T., Tanabe Y., Doi H., Kobayashi E., Hamanaka H., Bonfield W., Tokyo Medical and Dental University, Institute for Medical and Dental Engineering, Tokyo, Japan. II-89. Fatigue Evaluation of the Synthes Cervical Vertebrae Plate and the Synthes Anterior Cervical Vertebrae Plate. Zardiackas L.D., McGuire R., Dillon L., University of Mississippi Medical Center, Jackson, USA. BIORESORBABLES II-90. Bioabsorbable Screw Fixation of Distal Femoral Osteotomies in the Dog. Friedman R.J., An Y.H., Wingate J., Draughn R.A., Latour R.A., Powers D.L., Medical Univ. of Southern Carolina, Department of Orthopaedic Surgery, Charleston, USA. II-91. Hydrolysis of Absorbable Polymeric Biomaterials By Superoxide. Lee K.H., Won C.Y., Chu C.C., Cornell University, Department of Textile & Apparel, Fiber Science Program, Ithaca, USA. II-92. Bioabsorbable Surgical Tapes For Repairing Body Tissue. Liu C.K., United States Surgical Corp., Materials Research and Development, North Haven, USA. II-93. Degradation Behaviour Of PLLA By Enzymatic Hydrolysis. Muller D., David A., Pommer A., Muhr G., Bergmannsheil University Bochum, Department of Surgery, Bochum, Germany. II-94. Mechanical Properties and Degradation of Self-Reinforced SR-PLA Stereocopolymers In Vitro. Pohjonen T., Tormala P., Tampere University of Technology, Biomaterials Laboratory, Tampere, Finland. II-95. A New Approach to the Formation of Absorbable and Non-Absorbable Biomedical Polymers. Roweton S., Shalaby S.W., University of Connecticut, Polymer Science Program, Institute of Materials Science, Storrs, USA. II-96. Preparation and Structure Analysis of Carbonate-Apatite Single Crystals. Suetsugu Y., Tanaka J., National Institute for Research In Inorganic Materials, Ibaraki, Japan. II-97. In Vivo Evaluation of a Resorbable Interference Screw Made of 98% PLLA and 2% PDLA in a Functional Model. Therin M., Chambat P., Fayard J.P., Christel P., Biomatech, Medical Devices Testing Laboratory, Chasse, France. II-98. A Compensating Mechanism For Reduced Vascularity Near Eroding Polylactide- Polyglycolide In The Rabbit Bone Chamber. Winet H., University of Southern California, Department of Orthopaedics, Orthopaedic Hospital, Los Angeles, USA. II-99. Degradation Physico-Mechanical of Poly(L- Lactide Acid). Zavaglia C.A.C., Duek E.A.R., FEM - Unicamp Baraogeraldo, Dept. de engenharia de Materiais, Campinas, Brazil. BLOOD-MATERIAL INTERACTIONS II-100. Thrombogenicity Of Catheters In Human: 2-In Vitro Fibrinogen Binding and Platelet Retention. Bailly A.L., Laurent A., Lautier A., Lu H., Mundler O., Soria S., Merland J.J., DRC/DPIM AP-HP, Paris, France. II-101. Correlation of Hemocompatibility and Cytotoxicity Parameters With Physico- Chemical Surface Properties Of A Plasma Etched Silicone. Bienert H., Thelen H., Klee D., Hocker H., Mittermayer C., Jakse G., IZKF Biomat, Interdisciplinary Centre of, Clinical Research, Aachen, Germany II-102. Surface-Immobilized Heparin Triggers The Blood Coagulation Systems. Blezer R., Heijnen V., Fouache B., Hack E., Willems G.M., Lindhout T., University of Limburg, Department of Biochemistry, Maastricht, Netherlands. II-103. Structure-Anticoagulant Activity Relationships of Derivatized Dextrans: CMDBS. Chaubet F., de Raucourt E., Maiga-Revel O., Mauray S., Champion J., Fischer A.M., Jozefonvicz J., Universite Paris XIII, LRM CNRS-URA, Villetaneuse, France. II-104. Covalently Attached Polyethylene Glycol Reduces Platelet Deposition Onto Damaged Placental Arteries. Deible C.R., Chen C.T., Beckman E.J., Russell A.J., Wagner W.R., University of Pittsburgh, Department of Surgery & Chemical Engineering, Pittsburgh, USA II-105. New Heparin Sensor. Dror M., Schaad P., Baugh R., Meyerhoff M., Young V., Medtronic Blood Management, Parker, USA. II-106. The Effect of Polymer Structure and Processing On Surface Properties and In Vitro Hemocompatibility. Dujardin R., BAYER AG - Germany, Krefeld, Germany. II-107. Scintigraphic Anaylsis of Cell Adhesion in Oxygenators and Internal Organs. Eberhart R.C., Li J., Harris F.B., Sly M.K., Shastri P., Jessen M.E., Chao R., University of Texas Southwestern Medical Center, Dallas, USA. II-108. Near Surface Force Fields of Fibrinogen Measured With Atomic Force Microscopy. Eppell S., Danilich M.J., Holland N.B., Wilson D.L., Dalal P., Case Western Reserve University, Cleveland, USA. II-109. Blood Compatibility of Titanium Oxide Prepared By Ion Beam Enhanced Deposition. Feng Z., Xianghuai L., Nan H., Ping Y., Xiaolan Z., Yingjun M., Zhihong Z., Chinese Academy of Sciences, Ion Beam Laboratory, Shanghai Institute of Metallurgy, Shanghai, China. II-110. Protein Adsorption Studies With Non Contact AFM Onto Detoxification Membranes. Holtz M., Behrend D., Schroeder M., Roepke C., Schmitz K.O., University of Rostock, Clinic for Internal Medicine, Research Department, Rostock, Germany. II-111. Prevention of Platelet Adhesion By Surface- Grafted PEO. Park K., McPherson T., Johnson P.C., Purdue University, School of Pharmacy, West Lafayette, USA. II-112. Immunoassay Of Complement Proteins Deposited On Hemodialysis Membranes. Tian Y., Jenkins M., von Recum A., Acres G.S., Clemson University, Department of Bioengineering, Clemson, USA. BONE-MATERIAL INTERACTIONS II-113. The Long Term Osteoblast Response to Poly(anhydride-co-imides): A New Degradable Polymer for Use in Bone. Attawia M.A., Uhrich K., Herbert K.M., Langer R., Laurencin C.T., Medical College of Pennsylvania, Hospital, Department of Orthopaedic Surgery, Philadelphia, USA II-114. Bioactive Glass Increases Alkaline Phosphatase Activity in Rat Marrow Stromal Cells In Vitro. Baldick H., Ducheyne P., Leboy P., University of Pennsylvania, Department of Bioengineering, Philadelphia, USA. II-115. Osteoblast Population Chemotaxis on Substrates Modified With Adhesive Peptides. Bizios R., Dee K.C., Kantesaria P., Andersen T.T., Rensselaer Polytechnic Institute, Department of Biomedical Engineering, Troy, USA. II-116. The Effect of Growth Hormone on the Bone Ingrowth in Grooved Implants Coated With Calcium Phosphates. Blom E.J., Klein C.P.A.T., Verheij J.G.C., de Blieck-Hogervorst J.M.A., Beertsen W., Downes S., ACTA, Department of Implantology, Amsterdam, Netherlands. II-118. The Role of Exchanged Ions in Osteogenesis. Brook I., Carter D.H., Sloan P., Hatton P.V., University of Sheffield, School of Clinical Dentistry, Department of Oral & MF Surgery, Sheffield, UK. II-119. Effects Of Implant Surface Topography On Osteogenesis. Chehroudi B., Qu J.L., Brunette D.M., University of British Columbia, Oral Biology, Vancouver, Canada. II-120. Early Osteoinduction in Calcium Phosphate Ceramics in Various Species. Chen W., Qu S., Yang Z., Zhang X., Klein C., de Groot K., Sichuan University, Institute of Materials Science and Technology, Chengdu, China. II-121. Osteoclast Responses to Two Types of Experimental Calcium Phosphate Bone Cements. de Bruijn J., Bovell Y.P., Planell J.A., Driessens F.C.M., University of Leiden, Biomaterials Research Group, Bilthoven, Netherlands. II-122. Biological Evaluation of Ca-P RF Magnetron Sputter Coatings Using Osteoblast-Like Cells. de Ruijter J.E., Hulshoff J.E.G., van Dijk K., Schaeken H.G., Jansen J.A., University of Nijmegen, Department of Oral Function, Dental School, Nijmegen, Netherlands. II-123. Cells From Adult Human Jaw Bones Cultured On Tricalcium Phosphate and Fluorapatite Surfaces. De Santis D., Guerriero C., Nocini P.F., Armato U., Gotte P., University of Verona, Dental Department, Verona, Italy. II-124. Bone Growth in Metallic Bone Healing Chambers. Dziedzic D.M., Beaty K.D., Brown G.R., Heylmun T., Davies J.E., University of Toronto, Centre for Biomaterials, Toronto, Canada. COLLAGEN II-125. Complex Matrix Atelocollagen-Hyaluronic Acid for Skin Substitute. Bakos D., Hernandez-Fuentes I., Slovak Technical University, Faculty of Chemical Technology, Bratislava, Slovakia. II-126. Mineralization of Collagen Matrices To Produce Biomimetic Materials. Blumenthal N., Sakkos D., Crowley H., Hospital for Joint Diseases, Department of Bioengineering, New York, USA. II-127. Improving the Tensile Strength of Reconstituted Collagen Fiber Bundles. Cavallaro J.F., Ciarametaro P.D., Kemp P.D., Organogenesis Inc., Canton, USA. II-128. A Specific Quantitative Assay To Determine The Rate Of Collagen Synthesis In a Collagen Gel System. Doyle V., Pearson R.G., Lee D.A., Institute of Orthopaedics, IRC in Biomedical Materials, London, UK. II-129. Durability Of Collagen Fiber Scaffolds In Proteolytic Solutions. Dunn M.G., Weadock K.S., Miller E.J., Keuffel E.L., UMDNJ - Robert Wood Johnson Medical School, Orthopaedic Research Laboratory, New Brunswick, USA. II-130. Novel Collagen-Based Biomaterial For Cell Delivery. Estridge T.D., Collagen Corporation, Research and Development, Palo Alto, USA. II-131. Collagen as a Delivery Vehicle for Bone Morphogenetic Protein (BMP). Li S.T., Bolton W., Helm G., Gillies G., Frenkel S., ReGen Biologics Inc., Franklin Lakes, USA. II-132. Diffusion Properties of Capsular Tissue. Sharkawy A.A., Klitzman B., Truskey G.A., Reichert W.M., Duke University, Department of Biomedical Engineering, Durham, USA. II-133. Hybrid Apatite-Collagen Membranes. Taki T., Okazaki M., Matsuya T., Takahashi J., Osaka University, Faculty of Dentistry, Department of Dental Technology, Osaka, Japan. II-134. Production Of Collagens Type I and III In Human Bone Marrow Cultures. Wilke A., Ahmed M., Nagel R., Fuhrmann R., Griss P., Franke R.P., Philipps University, ZBMT University of Ulm, Department of Biomaterials, Ulm, Germany. II-135. Investigation of Collagen-Chitosan Composites. Zhang Q., Liu L., Ren L., Wang F., Chinese Academy of Medical Sciences, Institute of Biomedical Engineering, Tianjin, China. DENTAL MATERIALS II-136. Novel X-Ray Opaque Acrylic Denture Base Polymers. Davy K.W.M., Anseau M.R., University of London, Queen Mary & Westfield College, IRC in Biomedical Materials, London, UK. II-137. The New Au-Cu-Ag Alloy for Dental Metal- Ceramic Applications. Hautaniemi J.A., Ranta L., University of Turku, Department of Applied Physics, Turku, Finland. II-138. Transmitted Light Diffusion Through Human Enamel and Dentin. Inokoshi S., Kataumi M., Yamada T., Tagami J., Tokyo Medical and Dental University, Tokyo, Japan. II-139. Microstructural Effects In Machining Of Dental Glass-Ceramics. Jahanmir S., Xu H.H.K., Smith D.T., National Institute of Standards and Technology, Gaithersburg, USA. II-140. Elastic Properties Of Experimental Bioactive Glass Composites. Jones D.W., Rizkalla A.S., Smyth B., Ke V., Dalhousie University, Department Applied Oral Sciences, Faculties of Dentistry and Medicine, Halifax, Canada. II-141. Fitness of Titanium Cast MOD Inlay With Calcia-Based Investment. Katoh K., Tamaki Y., Fujimori S., Miyazaki T., Showa University School of Dent., Department of Oral Biomaterials & Technology, Tokyo, Japan. II-142. Comparison Of Human Saliva With Synthetic Electrolytes For Corrosion Testing Of Dental Materials Using The Thin Electrolyte Technique. Ledvina M., Rigney E.D., University of Alabama, Department of Materials and Mechanical Engineering, Birmingham, USA. II-143. Viscoelastic Behavior of Copolymers. Meyer J.M., Cattani-Lorente M.A., University of Geneva, School of Dentistry, Geneva, Switzerland. II-144. Tooth Temperatures During Electrothermal Bonding. Mizrahi E., Cleaton-Jones P.C., Landy C., Dental Research Institute, Department of Electrical Engineering, University of the Witwatersrand, Johannesburg, South Africa. II-145. Hamster Cheek Pouch Testing of a Gallium Alloy Restorative Material. Ong J.L., Carnes D.L., Gilles J.A., Burgess J.O., University of Texas, Health Science Center, Department of Restorative Dentistry, San Antonio, USA. II-146. A Soft Acrylic Material With An Unleachable Plasticiser. Parker S., Braden M., Martin D., LHMC, Department of Biomaterials in Relation to Dentistry, London, UK. II-147. Experimental Fluoride Releasing Cement Systems. Rizkalla A.S., Jones D.W., Hall G.C., Dalhousie University, Department Applied Oral Sciences, Faculties of Dentistry and Medicine, Halifax, Canada. II-148. Comparison of Different Retrograde Root Canal Filling Materials Using Bacterial Penetration Test. Schmitz H.J., Conrads G., Hansen M., Laurin T., Aachen University, Department of Oral/Maxillofacial and Facial Surgery, Aachen, Germany. II-149. The Wear Test For Filled and Unfilled Dental Resins. Wang W., Dibenedetto A.T., Goldberg J., University of Connecticut, Institute of Material Science, Storrs, USA. DRUG DELIVERY II-150. Composite Polymers in Controlled Release Drug Delivery Systems. Abdekhodaie M.J., Cheng Y.L., University of Toronto, Department of Chemical Engineering & Applied Chemistry, Toronto, Canada. II-151. Protein Release Kinetics Of A Porous Coated Implant Impregnated With A Biodegradable Delivery System. Agrawal C.M., Pennick A., Shen X., Szygenda D., Schenck R.C., University of Texas, Health Science Center, San Antonio, USA. II-152. Biodegradable Hydrogels For Temperature Sensitive Drug Delivery. Barman S.P., Rajaratnam J.B.M., Coury A.J., Pathak C.P., Focal Inc., Lexington, USA. II-153. Sustained Release of Polypeptides by Four Different Resorbable and Biodegradable Ceramic Delivery Devices. Benghuzzi H.A., Tucci M.A., Parsell D., Bajpai P.K., University of Mississippi, Medical Center, Department of Orthopaedics, Jackson, USA. II-154. Protonation Thermodynamics of Multiple- Stimuli Responsive Polymers In Drug Delivery Technology. Casolaro M., Barbucci R., University of Siena, Department of Chemistry, Siena, Italy. II-155. Contribution to the Characterization of New Graft Copolymers For Drug Delivery Systems. Castellano I., Gurruchaga M., Goni I., Facultad de Quimica, Departmento de Ciencia y Tecnologia, de Polimeros, San Sebastian, Spain. II-156. The Thermal Condensation Products of Polyelectrolyte Complexes As Possible Drug Delivery Systems. Cerrai P., Maltinti S., Guerra G.D., Tricoli M., Sbarbati Del Guerra R., Centro Studi Processi Ionici, C.N.R. & Department of Chemical Engineering, Pisa, Italy II-157. Succinylation of Insulin for Accelerated Iontophoretic Delivery. Corbett J.T., Dooley R.L., Michniak B.B., Zimmerman J.K., Shalaby S.W., Clemson University, College of Engineering and Sciences, Clemson, USA. II-158. The Study of CD Copolyesters for Drug Delivery System. Cui X., Song C., Wang P., Chinese Academy of Medical Sciences, Institute of Biomedical Engineering, Tianjin, China. II-159. Testosterone Containing Polyhdroxy Alkanoate Microcapsules and Solvent Cast Films: Effect of 60Co-gÊ Irradiation on Release Rate. Hasirci V., Gursel I., Middle East Technical University, Department of Biological Sciences, Biomaterials Research Lab, Ankara, Turkey II-160. New Polymethacrylic Carriers For Anti- inflammatory/ Analgesic Drugs. San Roman J., Parejo C., Serradilla C., Gallardo A., Liso P., Rebuelta M., CSIC, Instituto de C.y T. de Polimeros, Madrid, Spain. II-161. Ultramicroscopic Pore Size and Porosity Of Xerogels For Controlled Release Of Biological Molecules. Tan B.H., Santos E.M., Radin S., Ducheyne P., University of Pennsylvania, Department of Bioengineering, Philadelphia, USA. II-162. Preparation of Agarose Nanospheres. Wu X.S., Wang N., Long Island University, Division of Pharmaceutics, Brooklyn, USA. INFECTION II-163. Bacterial Colonization of Silver Modified Pins Surfaces For External Fixation: In Vitro Preliminary Observations. Cannas M., Tobin E.J., Sioshansi P., Masse A., Rizzo E., University of Torino, Human Anatomy, Novara, Italy. II-164. Prevention of Bacterial Proliferation on Metallic Implants By Means of Surface Coating. David A., Pommer A., Muller D., Eitenmuller J., Muhr G., Ruhr University, Department of Surgery, Kineiken Bergmannsheil, Bochum, Germany. II-165. An Experimental Animal Model to Study Haematogenous Implant Infections. Dhert W.J.A., Vogely H.C., Fleer A., Verbout A.J., Utrecht University, Cluster of Orthopaedics, Netherlands. II-166. Viral Inactivation of Bone Allografts Using Supercritical Fluid Extraction. Fages J., Frayssinet P., Bioland, Toulouse, France. II-167. Effects of Polyurethane Chemistry on Bacterial Adhesion and Colonization. Flemming R., Capelli C.C., Mosher D.F., Proctor R.A., Cooper S.L., University of Wisconsin, Department of Chemical Engineering, Madison, USA. II-168. Human Immunoglobulins to Prevent Biomaterial-Associated Infection (Passive Local Immunotherapy). Giridhar G., Gristina A.G., Medical Sciences Research Institute, Herndon, USA. II-169. Surface Functionalized Nanoparticles For Endotoxin Removal. Groth T., Darkow R., Albrecht W., Paul D., Paulke B.R., Institute of Chemistry, GKSS Research Centre, Teltow, Germany. II-170. Radiochemical Sterilization of Polymeric Devices: A New Low-Dose Process. Linden Jr. C.L., Shalaby S.W., Poly-Med Inc., Pendleton, USA. II-171. Hyaluronate Coatings For Fouling-Resistant Surfaces. Morra M., Cassinelli C., Benedetti L., Callegaro L., Ambrosio L., Nicolais L., Nobil Bio Ricerche, Villafranca d'Asti, Italy. II-172. Adhesion of Staphylococcus Epidermis Onto Modified Polyurethanes Surface. Park K., Kim Y., Suh H., Choi K., Kim Y.H., Bae E., Korea Institute of Science and Technology, Polymer Chemistry Lab, Seoul, Korea. II-173. Plasma-Deposited Glyme and Crown Ether Films Resist the Attachment of Pseudomonas Aeruginosa. Ratner B.D., Johnston E.E., Bryers J., University of Washington, Seattle, USA. II-174. Tissue Reactions to Bacteria-Inoculated Rat Lead Samples; Effect of Gentamycin Release From Modified Polyurethane. van Wachem P.B., van Luyn M.J.A., de Wit A.W., Raatjes D., Verhoeven M.L.P.M., Hendriks M., Cahalan P.T., University of Groningen, Netherlands II-175. Surface Properties of Foley Catheters: Relationship to Bacteriuria and Fouling. Wironen J., Marotta J., Beem E., Batich C., University of Florida, Department of Materials Science and Engineering, Gainesville, USA. ORTHOP(r)DICS II-176. Hydroxyapatite Application Effect On Micromotion Around Acetabular and Femoral Components In The Dog. Anderson G., Podworny N., Jain R., Kwok A.W.L., Waddell J.P., Dalhousie University, Faculty of Dentistry, Biomaterials Department, Halifax, Canada II-177. High Reliable Zirconia Ceramics for Orthopaedics. Cales B., C.T. Desmarquest, Evreux, France. II-178. Bone Morphogenetic Protein Composite for Monkey Spine Fusion. Damien C., Boden S.D., Schimandle J.H., Benedict J.J., Intermedics Orthopedics Inc., Wheatridge, USA. II-179. The Influence Of The Local Environment On The Incorporation Of Ceramic For Lumbar Fusion. Delecrin J., Aguado E., NGuyen J.M., Passuti N., Daculsi G., Faculte de Chirurgie Dentaire, Lab. de Recherche sur les tissus ca, Nantes, France. II-180. Pathology of Metal On Metal Total Hip Prostheses. Doorn P.F., Mirra J.M., Campbell P.A., Dorr L.D., van Sambeek K.J.M., Amstutz H.C., University of Southern California, Orthopaedic Hospital, Los Angeles, USA. II-181. Femoral Hip Stem Fatigue Testing: A Load Sharing Model. Hastings R., Mosher S., Woodling T., DePuy Inc., Warsaw, USA. II-182. Acceleration of Bone Formation With a Composite Made of Fibrin Sealant Platelet Factors and Natural Coral. Kania R.E., Meunier A., Petite H., Hamadouche M., Sedel L., University D.Diderot, Laboratoire de Recherches, Orthopediques, Paris, France. POLYETHYLENE II-183. Alterations in Microstructure of UHMWPE Due to Post-Irradiation Aging. Bellare A., Spector M., Cohen R.E., Brigham and Women's Hospital, Department of Orthopaedic Surgery, Boston, USA. II-184. Fusion Reversal - A White Band Formation Mechanism in Polyethylene. Bhambri S., King R., Devanathan D., Lin S., Zimmer Inc., Warsaw, USA. II-185. Influence of Sterilization Technique on Wear of Polyethylene. Eisenberg J., Mosleh M., Suh N.P., MIT, Dept. of Mechanical Engineering, Cambridge, USA. II-186. UHMW-PE Variations Smaller Than Perceived. Evans M.A., Lykins M.D., Poly Hi Solidur, Fort Wayne, USA. II-187. Correlation Between Oxidation Crystallinity and Density of Shelf-Aged UHMWPE Implants. Flynn M., Greer K.W., Hamilton J.V., Treacy D.J., Johnson & Johnson Professional Inc., Raynham, USA. II-188. Effect of Resin Type on the Oxidation of UHMWPE. Furman B.D., Furman G.L., Li S., Hospital for Special Surgery, Biomechanics, New York, USA. II-189. A Comparison of Sterilization Techniques of the Structure and Morphology of Medical Grade UHMWPE. Goldman M., Lee M., Pruitt L., Gronsky R., University of California at Berkeley, Department of Materials Science, Berkley, USA. II-190. Analysis of the Interrelationship Between Pitting Wear Oxidation Crystallinity and Storage Time for Shelf-Aged UHMWPE Implants. Greer K.W., Flynn M.A., Johnson & Johnson Professional Inc., Raynham, USA. II-191. Minimizing Oxidative Degradation on Gamma Sterilization. Gsell R.A., Lee K., Chu C., Lin S., Zimmer Inc., Warsaw, USA. II-192. An Oxidation Mechanism In gÊ-Sterilized Ultra-High-Molecular-Weight-Polyethylene Components. Muratoglu O.K., Bragdon C.R., Jasty M., Harris W.H., Massachusetts General Hospital, Orthopaedic Biomechanics Laboratory, Boston, USA. II-193. Results of a Two-Year Differential Scanning Calorimetry (DSC) Programme on UHMW- PE. Pascaud R.S., Evans W.T., McCullagh P.J.J., FitzPatrick D., Brummitt K., University of Glamorgan, Department of Mechanical Engineering, Mid Glamorgan, UK. II-194. Ultrastructure of UHMWPE Using Brittle Fracture and Atomic Force Microscopy. Shanbhag A., Rubash H.E., Pettit F.S., University of Pittsurgh, Department of Orthopaedic Surgery, Musculoskeletal Research Center, Pittsburgh, USA. II-195. The Concept of Stabilization in UHMWPE. Sun D., Wang A., Stark C., Dumbleton J.H., Howmedica Inc., Division of Pfizer Hospital, Products Group, Rutherford, USA. II-196. Aging of Calcium Stearate-Free Polyethylene. Swarts D., Gsell R., King R., Devanathan D., Wallace S., Lin S., Rohr W., Zimmer Inc., Warsaw, USA. II-197. Degradation of UHMWPE Due to Compression Molding and gÊ-Sterilization. Tanzi M.C., Brossa F.F., Chiesa R., Cigada A., Galli A., Paracchini L., Politechnic of Milan, Bioengineering Department, Milano, Italy. II-198. Effects of Sterilization Methods on the Wear of Ultra-High Molecular Weight Polyethylene Acetabular Cups. Wang A., Sun D.C., Stark C., Dumbleton J.H., Howmedica Inc., Division of Pfizer Hospital, Products Group, Rutherford, USA. II-199. The Effects of Processing and Sterilization on Ultra High Molecular Weight Polyethylene. Windau J.E., Mackin T.J., University of Illinois, Urbana, USA. II-200. The Adjustment of Elastic Modulus of Polyethylene Acetabular Cups. Zhu M.K., Dawson J.M., Spengler D.M., Vanderbilt University, Department of Orthopaedics and Rehabilitation, Austin, USA. POLYMERS II-201. Relationship Between Hydrophobicity of Micelles and Mechanical Properties of Hydrogels Generated Using Two Modes of Photoinitiation. Avila L.Z., Kieras M.T., Pathak C.P., Coury A.J., Focal Inc., Lexington, USA. II-202. The Influence of Casting Substrate on Surface Chemistry of Novel Blood Contacting Solution Cast Polyetherurethanes. Cable M., Finch D.S., Ralph B., Gilding K., Brunel University, Department of Materials Technology, Uxbridge, UK. II-203. Microbial Polyesters as Degradable Biomaterials. Chaput C., Selmani A., Yahia L.H., Rivard C.H., Ecole Polytechnique, Department of Chemical Engineering, Montreal, Canada. II-205. Sterilized Polyurethanes: Behaviour and Properties. Cuadrado T.R., Abraham G.A., Frontini P.M., National Research Council, National Univ. of Mar del Plata, Mar del Plata, Argentina. II-206. Poly (Ether Urethane) Calcification - Correlation of Computer Modeled Polymers With Calcification In Vivo. Frautschi J., Lupkowski M., Phillips R.E., Joshi R.R., Levy R.J., CarboMedics, Austin, USA. II-207. Polyelectrolyte Complexes Based on Chitosan. Guerra G.D., Cerrai P., Tricoli M., Petarca L., Sbarbati Del Guerra R., Maltinti S., Centro Studi Processi Ionici, C.N.R. & Department of Chemical Engineering, Pisa, Italy. II-208. Degradation of Polyurethane Nasogastric Feeding Tubes. Hinberg I., Rocheleau M.J., Karov J., Daka J.N., Chawla A.S., Medical Devices Bureau, Health Protection Branch, Health Canada, Ottawa, Canada. II-209. An Extraordinary Water Structure in Biocompatible Phospholipid Polymers. Ishihara K., Ueda T., Nomura H., Kurita K., Nakabayashi N., Tokyo Medical and Dental University, Institute for Medical and Dental Engineering, Chiyoda-ku, Japan. II-210. Novel Biocompatible Polyamides Prepared From Diamide-Diamines Containing Enzymatically Cleavable Bonds. La Cara F., Petillo O., Castaldo L., Maglio G., Palumbo R., Giordano V., Peluso G., Institute of Protein Biochemistry & Enzymology, Naples, Italy II-211. Adsorption of Cholesterol Esterase from Buffer to Surface Modified and Unmodified Polyurethanes: Correlation to Enzyme- Induced Degradation. McClung W.G., Santerre J.P., Brash J.L., Departments of Chemical Engineering and Pathology, McMaster University, Hamilton, Canada II-212. Design of A Synthetic Pneumosealant. Sawhney A., Lyman M.L., Focal Inc., Lexington, USA. II-213. Investigation of Preparation and Property of Hydrophilic Composites for Occluding Oviducts. Xue M., Xue P., Ning L., Li Y.W., Huang Z.W., Liu J., Gu G.Z., Shanghai Biomaterial Research and Test Center, Shanghai, China. SURFACE MODIFICATION II-214. Suspension Plasma Spraying of Hydroxyapatite For Bioceramic Coatings. Bouyer E., Gitzhofer F., Boulos M.I., University of Sherbrooke, Department of Chemical Engineering, Applied Sciences Faculty, Sherbrooke, Canada. II-215. Sterilization and Thermal Stability of Fluoropassive Polyester Fabric. Chinn J., Sauter J., Phillips Jr. R., Grobe III G., Ashton T., CarboMedics, Austin, USA. II-216. Plasma Polymers Coatings to Mimic Bioactive Ionomers. Daw R., Short R.D., Beck A.J., Brook I.M., University of Sheffield, Department of Engineering Materials, Sheffield, UK. II-217. Surface Modification of Metal Implants Using Reactive Ion Beams. Ektessabi A.M., Kyoto University, Faculty of Engineering, Kyoto, Japan. II-218. Aging Characteristics of Sol-Gel Zirconia Films on Ti6A14V. Filiaggi M.J., Pilliar R.M., University of Toronto, Centre for Biomaterials, Toronto, Canada. II-219. Diamond-Like Carbon Coating of Implants For Soft Tissue Applications. Finch D., Franks J., Blunn G.W., Lilley P., Brunel University, Department of Materials Technology, Uxbridge, UK. II-220. Thin Calcium Phosphate Coatings On Titanium By Spark Discharging In An Elecrolyte. Fujimori S., Itahashi H., Suzuki M., Miyazaki T., Showa University, School of Dent., Department of Oral Biomaterials & Technology, Tokyo, Japan. II-221. Characterization Of Vacuum Plasma-Sprayed Hydroxyapatite Coatings On Titanium Alloy Using Atomic Force Microscopy. Gledhill H.C., Turner I.G., Campbell P.A., Brown S.R., University of Bath, School of Materials Science, Bath, UK. II-222. Quantitative Assessment of the Surface Charge of Polymeric Biomaterials. Griesser H.J., Chatelier R.C., Drummond C.J., Gengenbach T.R., Vasic Z.R., CSIRO, Division of Chemicals and Polymers, Clayton, Australia. II-223. In Vitro Studies of Vacuum Plasma-Sprayed Hydroxyapatite Coatings. Ha S.W., Reber R., Mayer J., Wintermantel E., Gruner H., Guecheva M., Vonmont H., ETH Zurich, Schlieren, Switzerland. II-224. Mechanism of Improvement of Bone Conductivity in Titanium by Calcium-Ion- Implantation. Hanawa T., Asami K., Ukai H., Murakami K., Asaoka K., Tokushima University, School Of Dentistry, Department of Dental Engineering, Tokushima, Japan. II-225. A New Method For Amination Of Biomaterial Surfaces: Covalent Immobilization Of Heparin On Aminated Microporous Membranes. Hoffman A.S., Shimoboji T., University of Washington, Center for Bioengineering, Seattle, USA. II-226. Surface Modified Carbon For Femoral Head Component Of Hip Prosthesis. Hyvarinen J., Wielunski L.S., Clissold R.A., Brandwood A., Schindhelm K., University of New South Wales, Graduate School of Biomedical Engineering, Sydney, Australia. II-227. Chemical Patterning of Fluorocarbon Polymer: U.V. Excimer Laser Photochemistry and Ablation in Oxygen. Pireaux J.J., Girardeaux C., Caudano R., Facultes Universitaires Notre-Dame de la Paix, Laboratoire LISE, Namur, Belgium. TISSUE ENGINEERING II-228. Bone Substitute With Growth Factor Coral and Fibrinogen. Arnaud E., Molina F., Mendoza M., Fuente del Campo A., Ortiz Monasterio F., Hopital Necker Enfants Malades, Cranio-Facial Surgery Unit, Paris, France. II-229. Development of a Bioartificial Synthetic Extracellular Matrix-Equivalent for Nerve Regeneration. Borkenhagen M., Clemence J.F., Aebischer P., CHUV, Lausanne University Medical School, Surgical Research Division, Lausanne, Switzerland. II-230. Microencapsulation For Pituitary Cell Transplantation: The Importance Of Alginate Viscosity and Related Factors. Chen Z.P., Mohr G., McGill University, Division of Neurosurgery, Jewish General Hospital, Montreal, Canada. II-231. Effect Of Ligand Orientation On Hepatocyte Attachment Onto The Asialoglycoprotein Model (PVLA) (Difference In Cell Adhesion Between LB and Cast Films). Cho C.S., Takei R., Kobayashi A., Maruyama A., Kobayashi K., Akaike T., Chonnam National University, Dept. of Polymer Engineering, Kwangju, Korea II-232. Poly-l-Lysine (PLL) Concentration Alters The Permeability Of Poly-l-Lysine-Alginate Microcapsules. Chryssochoos J.T., Chaikof E.L., Hagler M.K., Weber C.J., Emory University School of Medicine, Department of Surgery, Atlanta, USA. II-233. Co-Cultured Vascular Cells In Collagen Gels. Furukawa K., Ushida T., Tateishi T., National Inst. for Adv. Interd. Res, Bionic Design Group, Ibaraki, Japan. II-234. Influence of Materials and Structures to Guided Tissue Regeneration Devices. Hierlemann H., Dauner M., Doser M., Planck H., Inst. of Textile and Process Eng., Department of Biomedical Engineering, Denkendorf, Germany. II-235. The Repair of Large Segmental Bone Defects is Achieved by Implanting Syngeneic Mesenchymal Stem Cells. Kadiyala S., Jaiswal N., Bruder S.P., Osiris Therapeutics Inc., Baltimore, USA. II-236. Hyaluronan-Based Biodegradable Scaffolds For Skeletal Tissue Reconstruction. Kim H.D., Valentini R.F., Brown University, Artificial Organs Biomaterials &, Cellular Technology Program, Providence, USA. II-237. The Chemical Modifications of Escherichia Coli L-Asparaginase with Carboxymethyl- Chitosans. Ma J., Li M., Qian G., He B., Institute of Polymer Chemistry, Nankai University, Tianjin, China. II-238. Porous Chitosan Scaffolds for Tissue Engineering. Matthew H.W.T., Madihally S.V., Watson V.K., Wayne State University, Chemical Engineering & Materials Science, Detroit, USA. ___________________________________________________________ Thursday, May 30: Oral Session 2 2:30-3:30 BIOCERAMICS Room 206A/B Chairs: U. Gross, D. Jones 2:30 I-239. Fatigue Behaviour of Surgical Grade Zirconia Ceramics. Cales B., Drouin J.M., C.T. Desmarquest, Evreux, France. 2:45 I-240. Apatite Formation Induced by Langmuir-Blodgett Monolayer. Cho S.B., Kikuchi M., Tanaka J., Azumi R., Matsumoto M., National Institute for Research, in Inorganic Materials, Ibaraki, Japan. 3:00: I-241. Injectable Phosphocalcic Bone Substitute: In-Vivo Study. Delecrin J., Dupraz A., Pilet P., Passuti N., Daculsi G., Laboratoire des tissue calcifies et biomateriaux, Nantes, France. 3:15: I-242. Clinical Application of Bioactive Glass Particles of Narrow Size Range. Schepers E., Ducheyne P., Barbier L., University of Leuven, Department of Prosthetic Dentistry, Leuven, Belgium. ION RELEASE Room 206C/D Chairs: L. Lucas, C.J. Kirkpatrick 2:30 I-243. Chromium Release From Co-Cr THR Components in Patients. Jacobs J., Black J., Skipor A., Paprosky W., Patterson L., Galante J., Rush-Presbyterian-St. Luke's, Medical Center, Department of Orthopaedic Surgery, Chicago, USA. 2:45 I-244. Systemic Influences of Metal Prosthetic Devices Undergoing Corrosion: Effects of Metal Ions on Blood Cell Adhesion to the Endothelium in a Dynamic In-Vitro Flow Chamber Model. Klein C., Otto M., Koehler H., van Kooten T.G., Kirkpatrick C.J., Johannes Gutenberg-University, Institute of Pathology, Division of Experimental Pathology, Mainz, Germany. 3:00: I-245. Cytotoxic Effects of Ions Released from Implant Materials. Lacy S., Lucas L.C., Univeristy of Alabama, Dept. of Biomedical Engineering, Birmingham, USA. 3:15: I-246. Influence of Metal Ions on Fibronectin Matrix and Focal Adhesion Formation by Human Endothelial Cells. Van Kooten T.G., Klein C.L., Kohler H., Otto M., Kirkpatrick C.J., University of Mainz, Division of Experimental Pathology, Institute of Pathology, Mainz, Germany. HEART VALVES Room 206E/F Chairs: J.M. Lee, R. Schroeder 2:30 I-247. Finite-Element Analysis of a New Design of Synthetic Leaflet Heart Valve. Clift S., Fisher J., University of Bath, School of Mechanical Engineering, Bath, UK. 2:45 I-248. Pyrolytic Carbon Roughness Effects on Platelet Adhesion. Goodman S., Sims P.A., Brendzel A.M., Albrecht R.M., University of Wisconsin, Department AHABS, Madison, USA. 3:00: I-249. In-Vivo Calcification Performance of Photooxidized Porcine Cusp and Root Tissue. McIlroy B., Moore M.A., Phillips R.E., CarboMedics, Austin, USA. 3:15: I-250. Fatigue of Bioprosthetic Heart Valve Leaflets. Sacks M.S., Smith D.B., Schroeder R., University of Miami, Dept of Biomedical Engineering, Coral Gables, USA CELL/SURFACE INTERACTIONS II Room 104A/B Chairs: J. Josefonvicz, J. Steele 2:30 I-251. Regulation Of Bone Resorption By Macrophage Derived Growth Factors. AL Saffar N., Kobayashi A., Jellie S., Revell P.A., Royal Free Hosp. School of Medicine, IRC in Biomedical Materials, Department of Histopathology, London, UK. 2:45 I-252. Confocal and Light Microscopic Evaluation of Silane Surface-Dependent Macrophage Development and Interleukin 4- Induced Foreign Body Giant Cell Formation. DeFife K., Jenney C.R., Colton E., Anderson J.M., Case Western University, Institute of Pathology , Dept of Biomedical Engineering, Cleveland, USA. 3:00: I-253. The Lymphokine Interleukin-4 Induces Very Large Foreign Body Giant Cells and Syncytia from Human Macrophages in a Material Surface Property-Dependent Manner In-Vitro. McNally A.K., Anderson J.M., Case Western University, Institute of Pathology , Dept. of Biomedical Engineering, Cleveland, USA. 3:15: I-254. Structural Characterization of a Map Decapeptide Reveals a Helical Nature. Olivieri M., Wollman R.M., Mysliwiec E.A., Alderfer J.L., D'Youville College, Buffalo, USA. INFECTION I Room 104C Chairs: A. Gristina, M. Mittelman 2:30 I-255. Early Bacterial Colonization of Titanium Oral Implant: The Effect of Wettability and Surface Roughness. Fare S., Rimondini L., Carrassi A., Brambilla E., Brossa F., Consonni C., Joint Research Centre, Institute For Advanced Materials, Ispra, Italy. 2:45 I-256. Preventing Prosthetic Infection Using A Crosslinked Albumin Coating In-Vivo. Friedman R.J., An Y.H., Bradley J., Powers D.L., Medical Univ. of Southern Carolina, Department of Orthopaedic Surgery, Charleston, USA. 3:00: I-257. Antimicrobial Activity of Remote Plasma Modified Polyurethane Against Biofilm Bacteria. Mittelman M.W., Sahi V.P., Soric I., Sodhi R.N.S., University of Toronto, Centre for Biomaterials, Toronto, Canada. 3:15: I-258. Bacterial Adhesion and Physical Property Analysis of a Series of Phosphonated Polyurethanes. Nagel J.A., Cooper S.L., University of Delaware, Department of Chemical Engineering, Newark, USA. ORTHOP(r)DIC/DENTAL IMPLANT MECHANICS Room 104D Chairs: H. Plenk, P.C. Noble 2:30 I-259. Visualization of the Fluid Patterns Developed During the Insertion of a Femoral Prosthesis into a Cement Mantle. Noble P.C., Collier M.B., Kamaric E., Baylor College of Medicine, Houston, USA. 2:45 I-260. Interface Pressures During Cyclic Loading of Cement Femoral Stems. Noble P.C., Liebs T.R., Alexander J.W., Monroe W.T., Baylor College of Medicine, Houston, USA. 3:00: I-261. Quantitative Determination of Relative Movement Effects on Bone Ingrowth With Porous-Coated Implants. Pilliar R.M., Deporter D.A., Watson P.A., Abdulla D., Valiquette N., Lindsay D., University of Toronto, Centre for Biomaterials, Toronto, Canada. 3:15: I-262. Strength Of Hydroxyapatite-Coated Fixateur Extern Pins In-Vivo. Pommer A., David A., Hahn M., Eitenmuller J., Muhr G., Ruhr University, Department of Surgery, Kineiken Bergmannsheil, Bochum, Germany. ___________________________________________________________ Thursday, May 30: Oral Session 3 4:00-5:30 BONE-MATERIAL INTERACTIONS I Room 206A/B Chairs: C.R. Howlett, T. Nakamura 4:00: I-263. Cytocompatibility Of 2 Ti-Alloys According to 3 Surface Treatments. Bordji K., Jouzeau J.Y., Mainard D., Delagoutte J.P., Netter P., Institut Euro. des Biomateriaux, Laboratoire de Pharmacologie, Vandoeuvre- les-Nancy, France. 4:15: I-264. Bonelike Apatite Layer Formed on Organic Polymers by Biomimetic Process. Kokubo T., Miyaji F., Kishimoto K., Nakamura T., Kyoto University, Faculty of Engineering, Division of Material Chemistry, Kyoto, Japan. 4:30: I-265. Interactions of Coatings of Dental Implants With Bone. Schmitz H.J., Erbe M., Lange R.T., Aachen University, Department of Oral/Maxillofacial, and Facial Surgery, Aachen, Germany. 4:45: I-266. Collagen Types Found at the Material- Tissue Interface. Shannon C., von Recum A.F., Thull R., Clemson University, Department of Bioengineering, Clemson, USA. 5:00: I-267. Tissue Interfaces to Dental Implants: Electron Microscopic Analyses. Steflik D.E., Lake F.T., Sisk A.L., Parr G.R., Hanes P.J., Buttle K.F., Medical College of Georgia, School of Dentistry, Department of Oral Pathology, Augusta, USA. 5:15: I-268. Evaluation of Osteoblastic Activity at Bone-Biomaterial Interfaces by In-Situ Hybridization. Voigt C., Neo M., Muller-Mai C., Gross U.M., Free University of Berlin, University Hosp. Benjamin Franklin, Berlin, Germany. BIORESORBABLES I Room 206C/D Chairs: S. Brown, A. Coury 4:00: I-269. A New Technique to Control the pH in the Vicinity of Biodegradable Implants. Agrawal C.M., Fan M., Zhu C., Athanasiou K.A., University of Texas, Health Science Center, San Antonio, USA. 4:15: I-270. Resorbable Continuous Fiber Reinforced Polymers for the Osteosynthesis Processing and Physico-Chemical Properties. Dauner M., Hierlemann H., Caramaro L., Missirlis Y., Panagiotopoulos E., Planck H., Inst. of Textile and Process Eng., Department of Biomedical, Engineering, Denkendorf, Germany. 4:30: I-271. Comparative Cytotoxicity of Poly(DTE Carbonate) and Poly(Lactic Acid). Frenkel S.R., Ricci J.R., Chen G., Hospital for Joint Diseases, Department of Bioengineering, New York, USA. 4:45: I-272. Biodegradable In-Situ Polymerizable Macromonomers - 2: Effect Of Polymerizable Group on Hydrogel Properties. Pathak C.P., Barman S.P., Coury A.J., Focal Inc., Lexington, USA. 5:00: I-273. In-Vitro Behaviour Copolymer P-L-La/ P-D-LA (96/4) in Presence or Absence of a Fibroblast Cell Line. Poddevin N., Frayssinet P., Bioland, Toulouse, France. 5:15: I-274. Bioresorbable Stents for Surgery of Tubular Organs. Tormala P., Valimaa T., Pohjonen T., Talja M., Petas A., Tampere University of Technology, Biomaterials Laboratory, Tampere, Finland. VASCULAR GRAFTS Room 206E/F Chairs: G. Adams, R. Guidoin 4:00: I-275. In-Vivo Performance of a Photooxidized Biologic Vascular Graft. Anderson J., McIlroy B.K., Phillips R.E., Weinberg S.L., Ashton T.A., CarboMedics, Austin, USA. 4:15: I-276. Lipids Bounded in the Structure of ePTFE Vascular Prostheses Implanted in Humans. Mantovani D., Vermette P., Guidoin R., Laroche G., Quebec Biomaterials Institute, Departments of Metallurgy & Surgery, Quebec, Canada. 4:30: I-277. In-Vivo Tracking of Endothelial Cells Seeded on Synthetic Vascular Prostheses. Poole-Warren L.A., Slowiaczek P.R., Noble K.R., Graham A.R., Schindhelm K., University of New South Wales, Graduate School of Biomedical, Engineering, Sydney, Australia. 4:45: I-278. Continual In-Vivo Assessment of 1 mm Diameter Vascular Prostheses. Skarada D.J., du Laney T.V., Steele T.M., Ritter E.F., Klitzman B., Duke University, Plastic Surgery Research Labs., Durham, USA. 5:00: I-279. Two and Three Dimensional Computed Tomography Angiography for Evaluation of Vascular Prostheses. Urban E., Zollner G., Chafke N., Kretz J.G., Dietemann J.L., Jahn C., Oswald P., Laboratoire de Physique et Mecanique Textiles, Mulhouse, France. 5:15: I-280. The Biocompound Graft: an Ultraflexible Hybrid Vessel Prosthesis for Cardiovascular Surgery. Zurburgg H.R., Zipfel B., Hetzer R., German Heart Institute, Berlin, Germany. CELLULAR EXPRESSION Room 104A/B Chairs: D. Grainger, F. Grinnell 4:00: I-281. Fibronectin Matrix Formation and Signalling via Integrins on Biomaterials. Altankov G., Grinnell F., Groth T., Bulgarian Academy of Science, Institute of Biophysics, Sofia, Bulgaria. 4:15: I-282. Monocyte Secretion of IL-1 and H2O2 In-Vitro. Gretzer C., Thomsen P., Institute of Anatomy & Cell Biology, Goteborg, Sweden. 4:30: I-283. Endothelial Cell Hemostatic Function on Biomaterial Surfaces Under Variable Shear Conditions. Huang E., Kottke-Marchant K., Cleveland Clinic Foundation, Department of Clinical Pathology, Hemostasis and Thrombosis Lab., Cleveland, USA. 4:45: I-284. Mechanical Strain Influences the Metabolism of Chondrocytes Cultured in an Artificial Matrix. Lee D.A., Bader D.L., Institute of Orthopaedics, IRC in Biomedical Materials, Stanmore, UK. 5:00: I-285. Application of the Low Vacuum Scanning Electron Microscope to the Study of Biomaterials and Cell Behaviour. Sammons R., Marquis P.M., University of Birmingham, School of Dentistry, Biomaterials Unit, Birmingham, UK. 5:15: I-286. Alteration of Human Endothelial Cell Morphology Growth and Their Interaction with Monocytes Mediated by Adhesion Molecules Under Cyclic Strain. Yun J.K., Anderson J.M., Ziats N.P., Case Western University , Institute of Pathology, Dept of Biomedical Engineering, Cleveland, USA. TISSUE ENGINEERING I Room 104C Chairs: J. Drauker, P. Aebischer 4:00: I-287. Effect of Amount of DBM In Polymer/ Collagen Scaffolds on Cell Behavior. Abboudi R., Zawadsky J.P., Tiku M.L., Maxian S.H., UMDNJ - Robert Wood Johnson Medical, School, Department of Orthopaedics, New Brunswick, USA. 4:15: I-288. 3-D Osteoblast Culture in Biodegradable Polymer Foams. Ishaug S.L., Crane G.M., Mikos A.G., Rice University, Department of Chemical Engineering, Institute of Biosciences and Bioeng., Houston, USA. 4:30: I-289. Bone Induction Achieved by Controlled Release of BMP From PLA/Hydroxyapatite Foams. Kadiyala S., Lo H., Ponticiello M.S., Reddi A.H., Leong K.W., John Hopkins University, Department of Biomedical, Engineering, Baltimore, USA. 4:45: I-290. Chondrocyte-Seeded Type I and Type II Collagen Implants Investigated In-Vitro. Nehrer S., Ramappa A.J., Breinan H.A., Shortkroff S., Yannas I.V., Spector M., Brigham and Women's Hospital, Orthopaedic Research, Boston, USA. 5:00: I-291. Chondrocyte and Osteoblasts Cultures in Polyester Foams. Rivard C.H., Rhalmi S., Chaput C., Selmani A., Yahia L.H., Des Rosiers E.A., St. Justine Hospital, Surgery Department, Montreal, Canada. 5:15: I-292. Bone Regeneration Using Emulsion Freeze-Dried PLGA Scaffolds with Median Pore Sizes Less than 50 mm . Whang K., Elenz D.R., Nam E.K., Tsai D.C., Thomas C.H., Nuber G.W., Bowen M.K., Northwestern Universtiy, Division of Biological Material, Chicago, USA. POLYETHYLENE I Room 104D Chairs: J.E. Parr, I.M. Hutchings 4:00: I-293. Phase Transformations and Molecular Alignment Induced by Gamma Irradiation and Deformation in Ultra High Molecular Weight Polyethylene. Choudhury M., Hutchings I.M., University of Cambridge, Department of Materials Science , & Metallurgy, Cambridge, UK. 4:15: I-294. Oil Red O Staining: Determining Oxidation of Ultra High Molecular Weight Polyethylene. Farber K.B., Collier J.P., Dartmouth College, Thayer School of Engineering, Hanover, USA. 4:30: I-295. The Role of Sterilization in Fatigue Wear of UHMWPE Tibial Components. Haggard W.O., Cristante S., Harris B.R., Carroll M.E., Trieu H.H., Parr J.E., Wright Medical Technology, Applied Technology Department, Arlington, USA. 4:45: I-296. Electron Spin Resonance Study of Free Radical Properties of Ultra High Molecular Weight Polyethylene upon gÊ-Irradiation. Lee K.H., Chu C.C., Gsell R.A., Lin S., Cornell University, Department of Textile & Apparel, Fiber Science Program, Ithaca, USA. 5:00: I-297. The Location of the Oxidation Maximum in Relation to the Post-Radiation History Of UHMWPE Implants. Sun D., Yau S.S., Dumbleton J.J., Stark C., Howmedica Inc., Division of Pfizer Hospital , Products Group, Rutherford, USA. 5:15: I-298. Investigation of Free Radicals in Shelf- Aged Polyethylene Tibial Components. Trieu H.H., Jahan M.S., Thomas D.E., Haggard W.O., Conta R.L., Parr J.E., Wright Medical Technology, Research and Development, Arlington, USA. ___________________________________________________________ Friday, May 31: Oral Session 4 8:30-10:30 SILICONES Room 206A/B Chairs: C. Batich, A.S. Chawla 8:30: I-299. Measurement of Silicon in Tissue Sites Both Adjacent to and Distant from Ruptured and Intact Silicone Breast Implants. Marotta J., LaTorre G., Batich C., Sisson Hardt N., Yu L., University of Florida, Department of Pathology, Department of Materials Sci. & Eng., Gainesville, USA. 8:45: I-300. Laboratory Evaluation of Explanted Gel Filled Silicone Breast Implants. Chawla A.S., Hinberg I., Health Canada, Medical Devices Bureau, Health Protection Branch, Ottawa, Canada. 9:00: I-301. Silicon Levels in Blood Breast Milk and Breast Capsules of Patients with Silicone Breast Implants and Controls. Lugowski S., Smith D.C., Semple J., Peters W., McHugh A., University of Toronto, Centre for Biomaterials, Toronto, Canada. 9:15: I-302. Mechanical Analyses of Explanted Breast Implants. Brandon H., Young V.L., Jerina K. , Wolf C., Washington University, St. Louis, USA. 9:30: I-303. Measurement of Gel Bleed from Silicone Breast Implants. Marotta J., LaTorre G., Batich C., Sisson Hardt N., Yu L., University of Florida, Deparment of Materials Science, and Engineering, Gainesville, USA. 9:45: I-304. Silicone Gel and Octamethylcyclo- tetrasiloxane (D4) Enhances Antibody Production to Bovine Serum Albumin in Mice. Nicholson III J., Hill S.L., Frondoza C.G., Rose N.R., John Hopkins University, Dept of Molecular Microbiology, Department of Orthopaedics, Baltimore, USA. 10:00 I-305. Silicone in the Blood and Capsule of Women with Breast Implants. Ricci J.L., Sun L., Alexander H., Klein A., Lattarulo N., Blumenthal N.C., Hospital for Joint Diseases, Department of Bioengineering, New York, USA. 10:15 I-306. Failure Characteristics of Explanted Breast Implants. Young V.L., Brandon H., Jerina K., Wolf C., Schorr M.W., Washington University, Cosmetic Surgery Center, St. Louis, USA. BIOCOMPATIBILITY II Room 206C/D Charis: J. Anderson, P. Giusti 8:30: I-307. Study of a Novel Biomaterial: Aramid- Silicone Resin. Akashi M., Furuzono T., Matsumoto T., Maruyama I., Kishida A., Kagoshima University, Faculty of Engineering, Kagoshima, Japan. 8:45: I-308. Minimization of Protein Adsorption and Cell Adhesion to a Grafted Copolymer of P(AAm-co-EG). Bearinger J.P., Rezania A., Chen J., Healy K.E., Northwestern Universtiy, Division of Biological Material, Chicago, USA. 9:00: I-309. Cellular and Cytokine Profiles of Periprosthetic Membranes Retrieved from Cemented and Uncemented Acetabular Components. Jones L.C., Frondoza C., Reidy H.J., Hungerford D.S., John Hopkins University, Department of Orthopaedic Surgery, Baltimore, USA. 9:15: I-310. Adhesion of Astrocytes to Charge Modified Silicon Substrates. Kam L., Shain W., Craighead H.C., Isaacson M., Roysam B., Szarowski D., Turner J.N., Rensselaer Polytechnic Institute, Department of Biomedical, Engineering, Troy, USA. 9:30: I-311. Commercially Pure Titanium Particles Elicit Low Superoxide Production from Human Monocytes/Macrophages In-Vitro. Kaplan D.S., Bianco P.D., Durfor C.N., Picciolo G.L., FDA - CDRH, Div. Mechanics and Materials Sci., Rockville, USA. 9:45: I-312. Angiogenic Potential of Methacrylic Acid(MAA) in a HEMA-MMA-MAA Co-Polymer. Kwon C., Rabinovitch M., Sefton M.V., University of Toronto, Department of Chemical Engineering, & Applied Chemistry, Toronto, Canada. 10:00 I-313. Use of a Synthetic Photopolymerized Biodegradable Hydrogel as a Pneumosealant. Sawhney A., Lyman M.L., Pichon D., Jarrett P.K., Rudowsky R., Focal Inc., Lexington, USA. 10:15 I-314. Osteoblast Attachment to 'Bioartificial' Polymers. Scotchford C., Cascone M.G., Giusti P., Downes S., University of Nottingham, Queen's Medical Centre, Department of Human Morphology, Nottingham, UK. BIORESORBABLES II Room 206E/F Chairs: M.F. Harmond, M. Grynpas 8:30: I-315. Heat Treatment of Coral Before Subcutaneous Implantation in Mice Decreased its Resorption. Fricain J.C., Choussat P., Rouais F., Baquey C., Dupuy B., UFR Odontologie, Universite de Bordeaux II, Bordeaux, France. 8:45: I-316. The Effect of Low-Temperature Plasma Treatment on Molecular Stability Mechanical Properties and Sterility of Polylactide Internal Fixation Devices. Gogolewski S., Mainil-Varlet P., Dillon J.G., Polymer Research, AO/ASIF Research Institute, Davos, Switzerland. 9:00: I-317. Material Properties of Poly(Desamino- tyrosyl-Tyrosine Ethyl Ester Carbonate) at Two Molecular Weights After Subcutaneous Implantation in the Rat. Macon N.D., Schwartz A., James K., Tong X., Charvet J., Ricci J., Integra Life Sciences Corporation, Plainsboro, USA. 9:15: I-318. Molecular Designing of Biodegradable Random Copolypeptide Hydrogels. Miyachi Y., Oka M., Hayashi T., University Osaka, Research Institute of Advanced, Science and Technology, Osaka, Japan. 9:30: I-319. Cellular Responses to Poly-L-lactic Acid Degradation Products. Pearson R.G., Lee D.A., Doyle V., Bader D.L., Institute of Orthopaedics, IRC in Biomedical Materials, Stanmore, UK. 9:45: I-320. Novel Degradable Biomaterials of Starch Based Polymers Reinforced with Bioactive Ceramics and Glasses. Reis R.L., Cunha A.M., Santos J.D., Allan P.S., Bevis M.J., Universidade do Porto, Department of Metallurgical , Engineering FEUP, Porto Codex, Portugal. 10:00 I-321. A Novel Porous Bone Substitute. Wells J., Grynpas M.D., Pilliar R.M., University of Toronto, Centre for Biomaterials, Toronto, Canada. 10:15 I-322. Novel Chemical Modification of Biodegradable Poly(Lactic Acid) by Grafting of Protected L-Lysine. Won C.Y., Lee K.H., Chu C.C., Cornell University, Department of Textile & Apparel, Fiber Science Program, Ithaca, USA. HYDROXYAPATITE Room 104A/B Chairs: P. Christel, W. Bonfield 8:30: I-323. Effect of Atmosphere on the Phase Transformation and Grain Growth of Carbonate Hydroxyapatite. Barralet J., Knowles J.C., Bonfield W., University of London, Queen Mary & Westfield College, IRC in Biomedical Materials, Tokyo, Japan. 8:45: I-324. Fatigue Failure in a Plasma Sprayed Hydroxyapatite Coated Titanium Alloy. Forrest D.J., Shelton J.C. , Gregson P.J., University of Southampton, Engineeering Materials, Southampton, UK. 9:00: I-325. A Novel Chondrocyte-Seeded Hydroxyapatite-Collagen Scaffold for Cartilage Repair. Friedman R.J., Tian Y., An Y.H., LaBreck J.C., Kang K., LaBerge M., Medical Univ. of Southern Carolina, Department of Orthopaedic Surgery, Charleston, USA. 9:15: I-326. Analysis of Vacuum Plasma Sprayed Hydroxyapatite Coatings on Titanium After Ageing in Ringer's Solution. Gledhill H.C., Turner I.G., University of Bath, School of Materials Science, Bath, UK. 9:30: I-327. Structure and Surface Morphology of TCP and HA Ceramics. Prieto Valdes J.J., Ortiz Lopez J., Pacheco Malagon G., Alfaro Hernandez S., Rueda Morales G., ESFM-IPN, UP A. Lopez Mateos, Departmento C. de Materiales, Mexico, Mexico. 9:45: I-328. Synthesis of Hydroxyapatite by the Oxidation of Solid Metal-Bearing Precursors. Saw E., Sandhage K.H., Gallagher P.K., Litsky A.S., Ohio State University, Dept. of Biomedical Engineering, Orthopaedic BioMaterials Laboratory, Columbus, USA. 10:00 I-329. Hydroxyapatite and Tricalcium Phosphate Ceramics Can Affect the pH of the Surrounding Medium and Consequent Protein Adsorption. Sharpe J., Sammons R.L., Marquis P.M., University of Birmingham, School of Dentistry, Biomaterials Unit, Birmingham, UK. 10:15 I-330. Spraying Conditions and Performance of Apatite-Coatings. Wahlmann U., Knepper M., Lugscheider E., Wagner W., University of Mainz, Klinik F. MKG-Chirurgie, Mainz, Germany. BLOOD-MATERIAL INTERACTIONS I Room 104C Chairs: S.L. Goodman, K.D. Hauch 8:30: I-331. Sulphated Hyaluronic Acid as Heparin- Like Molecule. Barbucci R., Lamponi S., Magnani A., Rhodes N.P., Williams D.F., University of Siena, CRISMA, Siena, Italy. 8:45: I-332. An Enzyme-Linked Immunoflow Assay for Quantifying Complement Activation. Black J., Yoo E.L., Sefton M.V., University of Toronto, Department of Chemical Engineering, Toronto, Canada. 9:00: I-333. Competitive Adsorption of HMWK and Fibrinogen from Binary Solutions and Plasma. Cornelius R., Archambault J., Brash J.L., McMaster University, Department of Chemical Engineering, Hamilton, Canada. 9:15: I-334. Platelet Activation by Biomaterials Indicated by Oscillations in Intracellular Free Calcium Concentration. Hauch K.D., Horbett T.A., University of Washington, Department of Chemical Engineering, and Center for Bioengineering, Seattle, USA. 9:30: I-335. Complement Interaction with Biomaterial Surfaces. Janatova J., Bernshaw N.J., University of Utah, Department of Bioengineering, Center for Biopolymers, Salt Lake City, USA. 9:45: I-336. Conformation of Fibrinogen Desorbed by PTFE Surface. Nanming Z., Yandao G., Fei L., Xiufang Z., Tsinghua University, State Key Lab. of Biomembrane and, Membrane Biotechnology, Beijing, China. 10:00 I-337. Adsorption and Activation of Proteins on Sulfonated Polylactide Surfaces Bearing Antithrombin and Anticomplement Agents. Trilokekar N., Tian Y., von Recum A.F., Clemson University, Department of Bioengineering, Clemson, USA. 10:15 I-338. Selective Plasminogen Binding: Modification of Surfaces by Cysteinyl-Lysine- Dextran and Lysinyl-Cysteine-Dextran. Warkentin P.H., Johansen K., Lundstrom I., Brash J.L., Linkoping University, Biomaterials Consortium, Linkoping, Sweden. COLLAGEN Room 104D Chairs: I.V. Yannas, H.A. Berg 8:30: I-339. Engineering Design of Composite Artificial Tendons and Ligaments. Ambrosio L., Iannace S., Nicolais L., University of Naples, Institute of Composite Material Tec., Naples, Italy. 8:45: I-340. Optimization of Ultraviolet Irradiation Crosslinking of Collagen Fibers. Bourke S.L., Hlibczuk V., Dunn M.G., UNDNJ - Robert Wood Johnson Medical, School, Division of Orthopaedics, New Brunswick, USA. 9:00: I-341. Effects of Incubation Time on In-Vitro Self-Assembly of Type I Collagen Molecules. Huang E.K., Pins G.D., Silver F.H., Christiansen D.L., UMDNJ, Robert Wood Johnson Medical School, Biomaterials Center, Piscataway, USA. 9:15: I-342. Non-Aldehyde Chemical Sterilization of Biological Tissue for Use in Implantable Medical Devices. Moore M., McIlroy B.M., Phillips R.E., CarboMedics, Austin, USA. 9:30: I-343. In-Vivo Evaluation of a Collagenous Membrane as an Absorbable Adhesion Barrier. Ramshaw J.A.M., Glattauer V., Edwards G.A., Nash T.J., White J.F., Brock K.A., Werkmeister J.A., CSIRO , Div. of Biomolecular Engineering, Parkville, Australia. 9:45: I-344. A New Injectable In-Situ Cross- Linkable Collagen Biomaterial. Rosenblatt J., Rhee W., Berg R., Collagen Corporation, Palo Alto, USA. 10:00 I-345. Evaluation of a Collagen-Based Biosynthetic Material for the Repair of Abdominal Wall Defects. Werkmeister J.A., Edwards G.A., White J.F., Casagranda F., Ramshaw J.A.M., CSIRO, Div. of Biomolecular Engineering, Parkville, Australia. ___________________________________________________________ Friday, May 31 : Keynote Session 11:00-12:00 Grand Ballroom 11:00 Keynote Lecture Patrick Aebischer, Division of Surgical Research, Lausanne University Medical School, Switzerland ÒThe Added Value of Biomaterials to Gene TherapyÓ Chair: M.V. Sefton 11:30 Keynote Lecture Geoffrey Ozin Department of Chemistry, University of Toronto, Canada ÒHierarchical Inorganic Materials: Skeletons in a BeakerÓ Chair: J.E. Davies ___________________________________________________________ Friday, May 31: Poster Session 2 1:00-2:30 ADHESIVES AND CEMENTS II-346. Amorphous Calcium Phosphate Cements. Driessens F., Boltong M.G., Fernandez E., Ginebra M.P., Planell J.A., Verbeeck R.M.H., De Maeyer E.A.B., ETSIIB-UPC, Department of Materials Science, Barcelona, Spain. II-347. Characterization Of A Calcium Phosphate Bone Cement. Fernandez E., Ginebra M.P., Boltong M.G., Driessens F.C.M., Ginebra J., De Maeyer E.A.P., Verbeeck R.M.H., ETSIIB- UPC, Dept. of Materials Science, Barcelona, Spain. II-348. The Effect of Treated PET Fiber Additions on the Fracture Toughness of Composite Bone Cement. FrIIs E.A., Kumar B., Cooke F.W., Yasuda H.K., Orthopaedic Research Institute Inc., Witchita, USA. II-349. Behaviour of a Calcium Phosphate Cement To Body Fluid Constituents. Ginebra M.P., Fernandez E., Boltong M.G., Driessens F.C.M., Planell J.A., ETSIIB-UPC, Department of Materials Science, Barcelona, Spain. II-350. Cement Technique Alters Creep Response of Acrylic Bone Cement. Gruen T.A., Norman T.L., Williams M.T., Blaha J.D., West Virginia University, Department of Orthopaedics, Morgantown, USA. II-351. Fatigue Characteristics Of Polyethyl- methacrylate Based Bone Cement Reinforced With Silane Coupled Hydroxyapatite. Harper E.J., Deb S., Behiri J.C., Bonfield W., University of London, Queen Mary & Westfield College, IRC in Biomedical Materials, London, UK II-352. Modified Cyanoacrylate Composition as Absorbable Adhesives For Soft Tissue. Linden Jr. C.L., Shalaby S.W., Poly-Med Inc., Pendleton, USA. II-353. The Effect of Vacuum Mixing on the Setting Properties and Porosity of Palavit LV and HV Low Curing Temperature Cement. Muller-Wille P., Lidgren L., Lund University Hospital, Department of Orthopaedics, Lund, Sweden. II-354. Effect of Specimen Preparation on Porosity and Fatigue Life: A Study of Centrifuged and Handmixed Cement. Noble P.C., Liebs T.R., Alexander J.W., Paravic V., Elliot A., Baylor College of Medicine, Houston, USA. II-355. Influence of Water Absorption On The Mechanical Properties Of A Modified Acrylic Bone Cement. Pascual B., Gurruchaga M., Goni I., Ginebra M.P., Gil F.J., Planell J.A., Levenfeld B., Facultad de Quimica, Bo IBAETA, San Sebastian, Spain. II-356. Powder-Fluid-Ratio Related Biocompatibility of Different Ionomeric Bone Cements. Schmitz H.J., Langer O., Zoellner W., Aachen University, Department of Oral/Maxillofacial and Facial Surgery, Aachen, Germany. BIOCERAMICS II-357. Acute Toxicity Of Hydroxyapatite Microcrystal Suspension By Intravenous Injection In Rats. Aoki H., Aoki H., International Apatite Institute, Tokyo, Japan. II-358. Effect Of Carbonate Content On The Precipitation and Sintering Of Apatite Gels. Best S.M., Barralet J.E., Bonfield W., University of London, Queen Mary & Westfield College, IRC in Biomedical Materials, London, UK. II-359. Porosity Measurements of ZCAP by Quantitative Image Analysis. Billotte W.G., Srinivasan R., Mehrotra G.M., Reynolds D.B., Bajpai P.K., Wright State University, BHE/ BME Department, Dayton, USA. II-360. Factors Affecting Compressive Strength Of Biphasic Calcium Phosphates. Bouler J.M., Trecant M., Delecrin J., Royer J., Passutti N., Daculsi G., Faculte de Chirurgie Dentaire, Lab. de Recherche sur les tissus, Nantes, France. II-361. Nano-Apatite/Polymer Composites: I. Mechanical and Physicochemical Characteristics. de Wijn J., Liu Q., van Blitterswijk C.A., University of Leiden, Biomaterials Research Group, Bilthoven, Netherlands. II-362. In Vivo Behaviour of Bioactive Glass For Regenerating The Cranial Defects. Deli G., Dassatti L., Deli R., Nicoletti F., Universita Cattolica del Sacro Cuor, Clinica odontoiatrica, Roma, Italy. II-363. Processing of Porous Bioactive Glass (45S5) For The In Vitro Synthesis of Bone-Like Tissue. Effah E.A.B., Ducheyne P., Shapiro I.M., University of Pennsylvania, Department of Bioengineering, Philadelphia, USA. II-364. Apatite Formation on Bamboo Utilizing Biomimetic Method. Li S., Liu Q., Weng J., Zhou B.L., de Groot K., de Wijn J.R., University of Leiden, Biomaterials Research Group, Bilthoven, Netherlands. II-365. Comparative Adsorption of Proteins on Different Apatitic Surfaces. Midy V., Rey C., Plouet J., Physico-Chimie des Solides, Toulouse, France. II-366. Formation of Variable Composition Hydroxyapatite. TenHuisen K., Brown P.W., Penn State University, University Park, USA. II-367. Bioactivity Of Sol-Gel Derived Organically Modified Silicates. Tsuru K., Osaka A., Ohtsuki C., Iwamoto T., Mackenzie J.D., Okayama University, Faculty of Engineering, Biomaterials Division, Okayama-shi, Japan. II-368. Evaluation Of Biological Responses To Biomaterials By mRNA Analysis. Akashi M., Kato S., Kishida A., Sugimura K., Kagoshima University, Faculty of Engineering, Kagoshima, Japan. II-369. Evaluation of Ca-P Plasma Spray and Sputter Coated Implants in Trabecular Bone. Hulshoff J.E.G., Hayakawa T., van Dijk K., van der Waerden J.P.C.M., Jansen J.A., University of Nijmegen, Laboratory of Biomaterials, Nijmegan, Netherlands. BIOCOMPATIBILITY II-370. Experimental In Vitro and In Vivo Studies of Epithelium Formation on Biomaterials Seeded by Isolated Respiratory Cells. Kaschke O., Gerhardt H., Bohm K., Olze H., Humboldt- University of Berlin, University Hospital Berlin Charite, Berlin, Germany. II-371. Efficacy of a Resorbable Hylan Barrier Membrane in the Prevention of Adhesions in a Rat Cecal Abrasion Model. Larsen N., Harris E.S., Foresman P.A., Rodeheaver G.T., Balazs E.A., Biomatrix Inc., Ridgefield, USA. II-372. Experiences on Connection of Different Porous Biomaterials to Improve the Design for an Alloplastic Tracheal Replacement. Olze H., Kaschke O., Muller W., Humboldt-University of Berlin, University Hospital Berlin Charite, Berlin, Germany. II-373. Application Of Stress Protein Assay For Evaluation Of Biomaterial Cytotoxicity. Oshima H., Hatayama T., Nakamura M., Osaka Dental University, Department of Biomaterials, Osaka, Japan. II-374. Degradation of Biomaterials and Confocal Raman Microspectroscopy. Radder A., van Loon J.A., Greve J., van Blitterswijk C.A, Leiden University, Biomaterials Research Group, Bilthoven, Netherlands. II-375. Prevention of Postoperative Perivascular Adhesions By Tissue Precoating With High Molecular Weight Polymers. Seeger J.M., Ingegno M.D., Albright J.L., Kirk J.F., Peck L., Klingman N.V., Goldberg E.P., University of Florida, College of Medicine, Gainesville, USA II-376. A Novel Accelerated Tissue Processing Technique For Use With Large Specimens of Bone-Containing Materials. Smith S.C., Kunishima D.H., Simon T.M., Ohland K.J., Jackson D.W., Aberman H.M., Howmedica Inc., Rutherford, USA II-377. Recruitment of Immunological Cells in Response to Crude Cytokines and Immunosuppressants Using a Hydrogel Block Model. Spargo B., Pacheco N.D., Rudolph A.S., Rollwagen F.M., Code 6910 Naval Research Lab, Center for Biomolecular Science, and Engineering, Washington, USA II-378. In Vivo pH Changes Near An Eroding Polylactide-Polyglycolide Device In The Rabbit Bone Chamber. Winet H., Martin C., University of Southern California, Department of Orthopaedics, Orthopaedic Hospital, Los Angeles, USA. BIOMECHANICS II-379. Measurement Of Cell Adhesion Strength To Material Surfaces. Yamamoto A., Mishima S., Ue Y., Maruyama N., Sumita M., National Research Inst. for Metals, Ibaraki, Japan. II-380. Evaluating Bone/Biomaterial Bonding Strength - A Comparison Of Different Techniques. Agrawal C.M., Wang X., Subramanian A., University of Texas, Health Science Center, San Antonio, USA. II-381. Effect of Fiber-Matrix Coupling on The Mechanical Properties of a Totally Bioabsorbable Composite. Alexander H., Perez B.J., Mayott C.W., Anderson L., Charvet J.L., Kohn J., LaCourse W.C., Hospital for Joint Diseases, Department of Bioengineering, New York, USA II-382. The Static Properties of The Canine Thoracic Duct. Deng X.Y., Guidoin R., Marois Y., Laval University, Department of Surgery, Sainte- Foy, Canada. II-383. Distal Design of a Cementless Femoral Hip Stem Component. Kelly W.J., Bushelow M., Schulzki M.J., Howmedica Inc., Division of Pfizer Hospital, Products Group, Rutherford, USA. II-384. Biomechanical Evaluation of a New Device For Posterior Plate Attachment in the Cervical Spine. Lee C.K., Overaker D.W., Kopacz K.J., Zimmerman M.C., New Jersey Medical School - UMDNJ, Department of Orthopaedics, Newark, USA. II-385. Mechanical Performance of Mixed-Metal Taper Connections. Nutt M.J., Boggan R.S., Carroll M.C., Merkel K.D., Wright Medical Technology, Arlington, USA. II-386. Bi-Directional Friction Properties At Bone- Implant Interface. Shirazi-Adl A., Hashemi A., Dammak M., Ecole Polytechnique, Dept. of Mechanical Engineering, Division of Applied Mechanics, Montreal, Canada. II-387. Fourier Regression Modeling of Articular Cartilage Surface. Smith S.T., Harris J.E., Hall M.A., Pace T.B., LaBerge M., Clemson University, Department of Bioengineering, Clemson, USA. II-388. Effect of Cement Modulus In The Femoral Hip Implant System. Smyth A.B., Jones D.W., Rizkalla A.S., Taheri F., Gross M., Dalhousie University, Department Applied Oral Sciences, Faculties of Dentistry and Medicine, Halifax, Canada. II-389. The Need For Accurate Ply-Level Stress Analysis In The Design of Laminated Composite Hip Prostheses. Srinivasan S., Biggers Jr. S.B, de Andrade J.R., Latour Jr. R.A., Clemson University, Department of Bioengineering, Clemson, USA. II-390. Mechanical and Physico-Chemical Properties of Synthetic Lars Ligaments. Tabrizian M., Yahia L.H., Leroy A., Ecole Polytechnique, Biomedical Engineering Institute, Montreal, Canada. II-391. Effectiveness Of Dye Penetrant Inspection For Predicting The Fatigue Performance Of Machined Cast Co Cr Hip Stems. Winters G.L., Intermedics Orthopedics Inc., Austin, USA. II-392. In Vitro Micromechanical Behavior of Viable Neonatal Mouse Tibia. Zhang G., Stern P.H., Lautenschlager E.P., Gilbert J.L., Northwestern University, Division of Biological Material, Chicago, USA. BIORESORBABLES II-393. In Vivo Evaluation Of Resorbable and Metal Interference Screws In An Ovine Model. Champion A.R., Cutshall T.A., Lower J., Adams S.B., Toombs J.P., Van Sickle D.C., DePuy DuPont Orthopaedics, Newark, USA. II-394. The Effect of the Surface Orientation of Resorbable Polymeric Membranes on the Attachment and Growth of Fibroblasts. Gugala Z., Gogolewski S., AO/ASIF Research Institute, Polymer Research, Davos, Switzerland. II-395. The Effects of Gamma and Ethylene Oxide Sterilization on Different Bioresorbable Polymers. Hutmacher D., Hurzeler M.B., Kirsch A., Albert-Ludwigs University, Department of Biomechanics and Biomaterials, Freiburg, Germany. II-396. Hydrolysis of Poly(l-lactide) and Poly(d l- lactide) Blends. Ikada Y.H., Tsuji H., Kyoto University, Research Center for Biomedical Engineering, Kyoto, Japan. II-397. Micelle Formation and Reaction Kinetics of a Bioabsorbable Photopolymerized Hydrogel. Jarrett P.K., Lalor C.B., Redmon M.P., Hickey A.J., Focal Inc., Lexington, USA. II-398. Electron Spin Resonance Study Of Free Radical Properties of Polyglycolic Acid Upon Gamma Irradiation Sterilization. Lee K.H., Chu C.C., Cornell University, Department of Textile & Apparel, Fiber Science Program, Ithaca, USA. II-399. Modification Of Poly(L-lactic Acid) Microspheres By The Chemical Addition Of Poly(acrylic Acid). Liggins R., Zhang X., Burt H.M., University of British Columbia, Faculty of Pharmacuetical Sciences, Vancouver, Canada. II-400. PGA and PLA as Biodegradable Polymers. Love B., Hayes M.D., Hallihan M.J., Aning A.O., Habenschuss A., Theiss T., Virginia Polytechnic Institute and State University, Blacksburg, USA. II-401. Mechanical and Molecular Properties of Polylactide Implants Subjected to In Vivo and In Vitro Degradation. Mainil-Varlet P., Curtis R., Gogolewski S., Polymer Research, AO/ASIF Research Institute, Davos, Switzerland. II-402. Response In The Rabbit To Degradable Polymeric Implants For Orthopaedic Use. Merolli A., Tranquilli Leali P., Gabbi C., Cacchioli A., Universita Cattolica, Clinica Ortopedica, Roma, Italy. II-403. Cell- and Tissue-Compatible Implant Materials/Synthesis. Neuenschwander P., Hirt T., Lendlein A., Kojima K., Matter S., Suter U.W., ETH Zurich, Institute of Polymers, Zurich, Switzerland. II-404. Injection Molding Process: Effects on The Characteristics Of Selected Poly(Alpha- Hydroxy) Acids. Poddevin N., Bioland, Toulouse, France. BLOOD-MATERIAL INTERACTIONS II-405. Synthetic Endothelial Surface With Phospholipid Polymer. Iwasaki Y., Ishihara K., Nakabayashi N., Tokyo Medical and Dental University, Institute for Medical and Dental Engineering, Chiyoda-ku, Japan. II-406. Complement-Mediated Leukocyte Adhesion on Poly(Etherurethane Ureas) Under Shear Stress In Vitro. Kao W.J., Sapatnekar S., Hiltner A., Anderson J.M., Institute of Pathology, Case Western University, Cleveland, USA. II-407. Prevention Of Platelet Adhesion Of Polysulfone Porous Catheter Tube By Saline Solution Perfusion In Vitro Ex Vivo and In Vivo Investigation. Khang G., Lee H.B., Park J.B., Korea Research Inst. of Chem. Tech., Biomaterials Lab, Teajon, Korea. II-408. Platelet Adhesion On Plasma-Treated Polyethylene Incorporating Sulfate And Phosphate Groups. Kim S.S., Yun J.I., Lee S.J., Korea Research Inst. of Chem. Tech., Biomaterials Lab, Teajon, Korea. II-409. Blood Compatibility of Hydrophilic Polyetherester Multi-Block Copolymer. Kuwahara H., Matsumura S., Ishihara K., Nakabayashi N., Teijin Limited, Polymers and Materials Research Laboratories, Yamaguchi, Japan. II-410. Interaction of Platelets on the Surfaces with Different Wettability. Lee H.B., Lee J.H., Jeong B.J., Korea Research Inst. of Chem. Tech., Biomaterials Lab, Teajon, Korea. II-411. Platelet Adhesion on Poly(Ether Urethane) Surfaces Modified By Polyethylene Oxide- Containing Block Copolymer Additives. Lee J.H., Joo Y.M., Lee W.K., Park K.D., Kim Y.H., Han Nam University, Dept. of Macromolecular Science, Teajon, Korea. II-412. Correlation Between Water Structure and Protein Adsorption. Miura M., Kiguchi A., Asahi Chemical Industry Co. Ltd., Designed Products Laboratory, Kawasaki City, Japan. II-413. Novel Surface Modifier for Blood Compatible Cellulose Hemodialysis Membrane. Miyano T., Kurita K., Ishihara K., Nakabayashi N., Tokyo Medical and Dental University, Institute for Medical and Dental Engineering, Chiyoda-ku, Japan. II-414. Characterizing Protein Adsorption Behavior on Biomaterial Surfaces. Nadarajah A., Lu J., Chittur K.K., University of Alabama, Dept. of Chemicals & Materials Engineering, Huntsville, USA. II-415. Investigation of Blood Compatibility of Titanium Alloy Modified By Plasma Source Ion Implantation. Nan H., Ping Y., Xiaonan Z., Yuanru C., Xianghuai L., Shichang Z., Southwest Jiatong University, Department of Materials Engineering, Chengdu, China. BONE-MATERIAL INTERACTIONS II-416. Development of Organic and Polymer Carriers For Demineralized Bone Matrix: Effect On Bone Cell Behavior. Abboudi R., Zawadsky J.P., Tiku M.L., Maxian S.H., UMDNJ - Robert Wood Johnson Medical School, Department of Orthopaedics, New Brunswick, USA II-417. Osteoconduction and Bone Bonding of Calcium Phosphates are Distinct Phenomena. Dziedzic D.M., Arita I.H., Chernecky R., Wilkinson D., Davies J.E., University of Toronto, Centre for Biomaterials, Toronto, Canada. II-418. The Effect Of Serum Protein Adsorption On Osteoblast Adhesion To Bioactive Glass and Hydroxyapatite. El-Ghannam A., Ducheyne P., Shapiro I.M., Desmos Inc., San Diego, USA. II-419. Bioglass Effect On Osteoblasts, Synoviocytes and Macrophages. Frondoza C., Gaies M.G., Radfar A., Bendall S.P., Jinnah R.H., Hungerford D.S., John Hopkins University, Department of Orthopaedic Surgery, Baltimore, USA. II-420. Bone-Implant Interface Evaluation of Alumina Coated With Bioactive Glasses. Hamadouche M., Meunier A., Nizard R., Kania R., Petite H., Sedel L., University D.Diderot, Laboratoire de Recherches, Orthopediques, Paris, France. II-421. Biodegradation Of Synthetic Biphasic Calcium Phosphate By Rabbit Osteoclasts In Vitro. Heymann D., Yamada S., Bouler J.M., Daculsi G., Faculte de Chirurgie Dentaire, Lab. de Recherche sur les mater, Nantes, France. II-422. Histomorphometric and Biomechanical Assessment Of Bone Ingrowth In Porous Hydroxyapatite. Hing K., Best S.M., Revell P.A., Tanner K.E., Bonfield W., University of London, Queen Mary & Westfield College, IRC in Biomedical Materials, London, UK. II-423. Bone Growth on Biodegradable Polymer Thin Films In Vitro. Holy C.E., Shoichet M.S., Davies J.E., University of Toronto, Centre for Biomaterials, Toronto, Canada. II-424. Diffusion of Titanium, Calcium and Phosphorus Measured By Pixe at the Bone- Prosthesis Interface. Irigaray J.L., Oudadesse H., Jallot E., Weber G., Therin M., Universite Blaise-Pascal, Lab. de Physique Corpusculaire, Aubiere, France. II-425. A Simple Method To Estimate Affinity Of Hydroxyapatite Materials For Tissue Cells. Ishikawa K., Oguchi H., Furuta I., Yamago G., Eguchi G., Toyama Medical & Pharm. University, Faculty of Medicine, Dept. of Oral & Maxillo. Surgery, Toyama, Japan. II-426. Early Bone Formation Around Anodic Oxide Titanium Implant After Hydrothermal Treatment. Kajimura K., Itoh S., Ishizawa H., Shioyama T., Ishibashi K., Iwate Medical University, Department of Fixed Prosthodontics, School of Dentistry, Morioka, Japan. II-427. Proteoglycans at the Bone-Biomaterial Interface In Vitro. Klinger M., Rahemtulla F., Prince C.W., Lucas L.C., University of Alabama, Department of Biomedical Engineering, Birmingham, USA. II-428. In Vitro Examination of Novel Calcium Phosphates Using Osteogenic Cultures. Knabe C., Gildenhaar R., Berger G., Ostapowicz W., Fitzner R., Radlanski R., Gross U., Free University of Berlin, University Hosp. Benjamin Franklin, Dept. of Prosthodontics II, Berlin, Germany II-429. Bone Ingrowth Into Porous Ceramics With Different Pore Sizes. Mainard D., Galois L., Bordji K., Clement D., Delagoutte J.P., Institut Euro. des Biomateriaux, Institut de Recherches Chirmi, Vandoeuvre-les-Nancy, France. CARDIOVASCULAR DEVICES II-430. Magnetic Resonance Time Course Study of the Body's Response to the Presence of Vascular Prostheses. Alikacem N., Stroman P., Marois Y., Lemberger B., Guidoin R., Laval University, Quebec Biomaterials Institute, St. Francois d'Assise Hospital, Quebec, Canada II-431. Microwave-Aldehyde Preservation Of Porcine Leaflets. Chamma T.S., Shafique T., Johnson R.J., Dvorak A.M., Login G.R., Beth Israel Hospital, Department Pathology, Boston, USA. II-432. Synergistic Inhibition Of Calcification Of Bioprosthetic Heart Valves With Preincubation In Ferric Ion and a-Amino Oleic Acid. Chen W., Myers D.J., Levy R.J., University of Michigan, Medical Center, Division of Pediatric Cardiology, Ann Arbor, USA. II-433. Thrombosis Inflammation and Healing of Fluoropassive Polyester Fabric. Chinn J.A., Sauter J., Phillips Jr. R., Kao W., Anderson J., Hanson S., Ashton T., CarboMedics, Austin, USA. II-434. Relating The Frequency Dependent Radial Compliance To The Tensile Modulus of Polyurethane Vascular Grafts. Conti J.C., Bozzi R., Rohde D., Soldani G., Spence L., Strope E., Withrow D., Dynateck Dalta Scientific Instruments, Galena, USA. II-435. Russian E-PTFE Vascular Prostheses: In Vivo Biomedical Evaluation. Dobrova N.B., Gorodkov A.Y., Sydorenko E.S., Schekhter A.B., Scientific Centre of Cardio-vascular Surgery, Moscow, Russia. II-436. Design of an Expanded PTFE Graft For Femorodistal Bypass. How T., Enzler M., Black R.A., Harris P.L., University of Liverpool, Clinical Engineering, Faculty of Medicine, Liverpool, UK. II-437. The Effect of Gamma Sterilization on the Activity of Collagenase. Hu C.B., Ma M., Myers K.E., Hsu L.C., Baxter Healthcare Corporation, Irvine, USA. II-438. Non-Toxic Embolic Liquid for Treatment of Arteriovenous Malformations. Iwata H., Kazekawa K., Morikawa N., Matsuda S., Ikada Y., Kyoto University, Research Center for Biomedical Engineering, Kyoto, Japan. II-439. Calcification Mitigation on Glutaraldehyde- Fixed Biological Tissue by Dimethylsulfoxide. Khor E., Wee A., Loke W.K., Tan B.L., Tee C.F., National University of Singapore, Chemistry Department, Kent Ridge, Singapore. COMPOSITES II-440. High Strength Partially Absorbable Composites Produced by Sintering Method for Internal Bone Fixation. Fenner R., Fambri L., Migliaresi C., University of Trento, Department of Materials Engineering, Trento, Italy. II-441. Poly(L-Lactide) and Poly(L-Lactide)- Ceramic Filled Composites: A Long Term In Vivo/In Vitro Degradation Study. Jones N., Williams D.F., University of Liverpool, Clinical Engineering, Liverpool, UK. II-442. Hydrostatic Extrusion of Hydroxyapatite Polyethylene Composite. Ladizesky N.H., Wang M., Miettinen E.M., Tanner K.E., Ward I.M., Bonfield W., University of Leeds, IRC in Polymer Science & Technology, Leeds, UK. [*Withdrawn*] II-443. Nano-Apatite/Polymer Composites II. Surface Modification of Nano-Apatite by Grafting of Polyethylene Glycol. Liu Q., de Wijn J.R., van Blitterswijk C.A., Leiden University, Biomaterials Research Group, Bilthoven, Netherlands. II-444. The 'Halo' Effect: Surface Reactions of a Bioactive Glass Fiber/Polymeric Composite In Vitro and In Vivo. Marcolongo M.S., Ducheyne P., Schepers E., Garino J., DePuy DuPont Orthopaedics, Newark, USA. II-445. Dynamic Mechanical Analysis Of Hydroxyapatite Reinforced Polyethylene. Nazhat S.N., Smith R., Tanner K.E., Bonfield W., University of London, Queen Mary & Westfield College, IRC In Biomedical Materials, London, UK. II-446. Effect Of Composition On Strength Of Bioactive Composites. Rizkalla A.S., Jones D.W., Chiarot M., Hall G.C., Dalhousie University, Department Applied Oral Sciences, Faculties of Dentistry and Medicine, Halifax, Canada. II-447. Study on OAP/Al2O3 Biocomposite Materials. Zhixiong Y., Shaoxia Z., Guiju L., Chinese Academy of Sciences, Shanghai Institute of Ceramics, Shanghai, China. DENTAL IMPLANTS II-448. Bone Temperature Rise During Drilling. Abouzgia M.B., Symington J.M., James D.F., Toronto Hospital, Department of Oral & Maxillofacial, Surgery, Toronto, Canada. II-449. Role of Incision Design on The Implant Host Site. Cranin A.N., DeGrado J.D., Sayed A., Brookdale Hospital, Dental Implant Group, Brooklyn, USA. [*Withdrawn*] II-450. Quantitative Measurement of Metal Ion Release From Orthopedic and Dental Implants. Ektessabi A., Otsuka T., Tsuboi Y., Yokoyama K., Albrektsson T., Sennerby L., Johansson C., Kyoto University, Faculty of Engineering, Kyoto, Japan. II-451. Animal Study To The Initial Bone Healing of Oral Implants. Jansen J.A., Caulier H., Vercaigne S., van der Waerden J.P.C.M., Wolke J.G.C., Naert I., University of Nijmegen, Department of Oral Function, Dental School, Nijmegen, Netherlands. II-452. Effect of Dental Implant Diameter on the Initial Stability and on Pull-Out Resistance. Kido H., Kumar A., Shulz E.E., Lozada J., Morikawa M., Saha S., Loma Linda University, Dept. of Restorative Dentistry, School of Dentistry, Loma Linda, USA. II-453. Preparation of Hydroxyapatite Coating By Ion Beam Enhanced Deposition. Li X., Weng J., Zhang X., Wang P., Liu Z., Jiang J., Sichuan University, Institute of Materials Science and Technology, Chengdu, China. II-454. New Bone Growth Around The Ostial Implant After Installation. Symington J.M., Listrom R.D., Yu Q.X., Zhao Y.F., Mendes M., Smith D.C., University of Toronto, Faculty of Dentistry, Department of Oral Surgery, Toronto, Canada. II-455. Clinical Evaluation For HA-Coated Implant With High-Velocity Flame-Spraying. Tadashi S., Keiko I., Ryu-ichi T., Isao F., Toyama Medical & Pharmaceutical University, Department of Oral & Maxillofacial Surgery, Toyama, Japan. II-456. Bone Remodelling Around Osseointegrated Implants Retrieved From Patients. Tsuboi Y., Tsuboi N., Sennerby L., Albrektsson T., Roos J., Johansson C.B., IIzuka T., Kyoto University, Faculty of Medicine, Dept. of Oral and Maxillofacial Surgery, Kyoto, Japan. II-457. Release of Ni and Ti in Some Organs After Endosseous Implanting SMI. Wang H., Bao S.F., Ma L., Stomatology Dept. and Trace Elements Lab of General Hospital of PLA, Beijing, China. II-458. Induction of Bone-Like Apatite in Simulated Body Fluid by Amorphous Phase in Plasma- Sprayed Hydroxyapatite Coatings. Weng J., Liu Q., Wolke J.G.C., Zhang X.D., de Groot K., Sichuan University, Institute of Materials Science and Technology, Chengdu, China II-459. The Influence of Surface Roughness on Implant Take. Wennerberg A., Albrektsson T., University of Goteborg, Department of Handicap Research, Biomaterials Group, Goteborg, Sweden. II-460. Solubility Control of Thin Hydroxyapatite Coatings by Rapid Heating. Yoshinari M., Igarashi T., Inoue T., Shimono M., Tokyo Dental College, Chiba, Japan. DRUG DELIVERY II-461. TCPL Steroid Delivery System and the Analysis of Fibrous Tissue Using Adult Rams as a Model. Benghuzzi H.A., England B.G., University of Mississippi, Medical Center, Department of Orthopaedics, Jackson, USA. II-462. The Role of Tricalcium-Phosphate Lysine Particle Sizes on the Sustained Release of Steroids and Proteins. Benghuzzi H.A., Parsell D., University of Mississippi, Medical Center, Department of Orthopaedics, Jackson, USA. II-463. Drug Release From Nanospheres Based On Polymeric Micelles. Cho C.S., Jeong Y.I., Kim S.H., Lee Y.M., Sung Y.K., Akaike T., Chonnam National University, Dept. of Polym. Eng., Kwangju, Korea. II-464. A Novel Approach to Drug Delivery: Molecular Encapsulation Within Microcapsules. Hasirci V., Gursel I., Middle East Technical University, Department of Biological Sciences, Biomaterials Research Lab, Ankara, Turkey. II-465. Preparation and Clinical Application of Hydroxyapatite Ceramics With Drug Delayed Releasing Effect. Hu X., Chengdu Military General Hospital, China. II-466. Controlled Release System for Bone Morphogenetic Protein. Isobe M., Yamazaki Y., Ishihara K., Nakabayashi N., Amagasa T., Tokyo Medical and Dental University, Institute for Medical and Dental Engineering, Chiyoda-ku, Japan. II-467. Convectional Drug Release Using Fast Deswelling Response of Comb-Type Grafted Poly(N-Isopropylacrylamide) Hydrogels. Kaneko Y., Sakai K., Kikuchi A., Aoyagi T., Sakurai Y., Okano T., Tokyo Women's Medical College, Institute of Biomedical Engineering, Tokyo, Japan II-468. Synthesis and Characterization of Polylysine- Graft-Hyaluronic Acid Copolymer as Gene Carrier To Liver Endothelial Cells. Maruyama A., Asayama S., Nogawa M., Akaike T., Takei Y., Tokyo Institute of Technology, Dept of Biomolecular Engineering, Faculty of Bioscience & Technology, Yokohama-shi, Japan II-469. Application of Receptor-Directed Glycopolymers For Magnetic Resonance Imaging Contrast Media. Mikawa M., Maruyama A., Naota M., Akaike T., Tokyo Institute of Technology, Dept of Biomolecular Engineering, Faculty of Bioscience & Technology, Yokohama-shi, Japan II-470. Novel Design of Biodegradable Supramolecular Assembly for Drug Delivery. Ooya T., Yui N., Japan Advanced Institute of Science and Technology, Ishikawa, Japan. II-471. Glucose and Sulfonylurea Co-Carrying Polymer Synergistically Enhances Insulin Secretion from Insulinoma Cell(MIN6) - New Material For Developing An Artificial Pancreas. Park K.H., Goto M., Maruyama A., Kobayashi K., Miyazaki J.I., Ogawara H., Akaike T., Tokyo Institute of Technology, Department of Biomolecular Engineering, Faculty of Bioscience & Technology, Yokohama-shi, Japan. II-472. A Heterocyclic Polymer-Water Absorption/ Drug Release. Patel M.P., Tibaldi J., Clarke R.L., Braden M., LHMC, Department of Biomaterials in Relation to Dentistry, London, UK. II-473. Role of TiO2 Bioceramic on the Release of Fluoride from Hydrophobic and Hydrophilic Composites with Acrylic Polymers. Vallet-Regi M., Pena J., Martinez A., San Roman J., Dpto. de Quimica Inorganica, Fac. de Farmacia, Madrid, Spain. II-474. Protein Release Kinetics from Natural Rubber Latex. Watkins M.H., Abhiraman A.S., Chaikof E.L., Emory University School of Medicine, Department of Surgery, Atlanta , USA. METALS II-475. Potentiodynamic Anodic Polarization Behaviour of Three Porous Sintered Surgical Alloys. Becker B.S., Bolton J.D., University of Bradford, Department of Mechanical Engineering, Bradford, UK. II-476. Preparation and Characterization of Ti-Al-Nb Alloys for Orthopaedic Implants. Caram R., Oliveira V., Bertazzoli R., State University of Campinas, Campinas, Brazil. II-477. Nitrogen Diffusion Hardening for Titanium and Ti-6-Al-4V Alloy. Gil F.X., Rodriguez D., Sanchez E., Manero J.M., Planell J.A., ETSEIB University Politecnica de, Catalunya, Department of Materials Science, Barcelona, Spain. II-478. A Quantitative Comparison of Titanium Implants. Johansson C., Wennerberg A., Han C., Albrektsson T., Goteborg University, Department of Biomaterials/Handicap Res., Goteborg, Sweden. II-479. Corrosion Characteristics of Ortron 90 Alloy. Karov J., McDougall B., Hinberg I., National Research Council, Medical Devices Bureau, Ottawa, Canada. II-480. Titanium Alloys - Corrosion and Wear Studies In-Vitro. Khan M. , Williams R.L., Williams D.F., University of Liverpool, Clinical Engineering, Faculty of Medicine, Liverpool, UK. II-481. Alloy-Design Of Titanium-Zirconium Based Alloys Containing Niobium as Biomedical Materials. Kobayashi E., Doi H., Yoneyama T., Hamanaka H., Best S.M., Shelton J.C., Bonfield W., Tokyo Medical and Dental University, Institute for Medical and Dental Engineering, Tokyo, Japan. II-482. New Cell Design for Electrochemical Investigations of Metallic Biomaterials. Muller W., Ibendorf K., Schopf C., Lange K., Humboldt-University of Berlin, University Hospital Berlin Charite, Berlin, Germany. II-483. Corrosion Resistance and Corrosion Fatigue Strength Of New Titanium Alloys For Medical Implants Without V and Al. Okazaki Y., Ito Y., Kyo K., Tateishi T., Ministry of Intern. Trade and Indus, Agency of Industrial Science and Technology, Mechanical Engineering Laboratory, Ibaraki, Japan. II-484. The Relation of Microstructure to the Corrosion Behavior of CoCr Porous Coatings on Orthopaedic Implants. Placko H.E., Brown S.A., Payer J.H., University of Alabama, Department of Biomedical Engineering, Birmingham, USA. II-485. Fatigue Properties of Annealed and Cold Worked Implant Metals. Pypen C., Mayer H., Stanzl-Tschegg S., Plenk Jr. H., University of Vienna, Histol. Enbryol. Inst., Department of Bone and Biomat. Res., Vienna, Austria. II-487. Static Corrosion of Ti6Al4V/CoCr with Varying Crevice Widths at Low pH. Yang X.M., Bapst J.M., Intermedics Orthopedics Inc., Austin, USA. II-488. A New Medical Titanium Alloy. Zuochen L., Qingzhi W., Changliang L., Yongqing Z., Northwest Institute for Nonferrous Metal Research, Xi'an Shaanxi, China. OPHTHALMOLOGY II-489. Rheological Assessment of Potential Vitreous Substitutes. Dalton P., Chirila T.V., Jefferson A.J., Curtin University of Technology, Nedlands, Australia. II-490. Novel Collagen-Based Biomaterials For Ophthalmic Use II: Biocompatibility. Dupont D., Gravagna P., Rao P.R., Chow A.A., Harner C.H., CollOptics Inc., Palo Alto, USA. II-491. Increasing the Biocompatibility of Keratoprosthesis Materials. Fitton J.H., Clayton A.B., Hicks C.R., Ziegelaar B.W., Vijayasekaran S., Dalton P.D., Hong Y., Lions Eye Institute, Perth, Australia. II-492. Surgical Approaches to Reducing Keratoprosthesis Extrusion in an Animal Model. Hicks C.R., Dalton P.D., Clayton A.B., Vijayasekaran S., Fitton J.H., Ziegelaar B.W., Chirila T.V., Lions Eye Institute, Nedlands, Australia. II-493. Characterization of PVP Hydrogels as Potential Vitreous Substitutes. Hong Y., Chirila T.V., Vijayasekaran S., Fitton J.H., Dalton P.D., Ziegelaar B., Constable I.J., University of Western Australia, Centre for Ophthalmology and Visual Science, Nedlands, Australia. II-494. Irreversible Binding of Protein on Poly(hema)-Based Hydrogel Contact Lenses and Carboxymethyl-Poly(hema) Hydrogel Discs. Garrett Q., Chatelier R., Griesser H., Milthorpe B.K., University of New South Wales, Graduate School of Biomedical Engineering, Sydney, Australia. II-495. Creep Profiles of 14 Multifunctional Polymeric Bands After Implantation in the Rabbit Eye. Jacob-Labarre J.T., Lin J.J., LSU Eye Center, New Orleans, USA. II-496. Novel Collagen-Based Biomaterials For Ophthalmic Use I: Formulations Development. Rao P.R., Chow A.A., Uhlrich S., Gravagna P., Harner C.H., Chu G.C., Geroski D.H., CollOptics Inc., Palo Alto, USA. II-497. Histopathology of PVP Hydrogels as Vitreous Substitutes. Vijayasekaran S., Chirila T.V., Hong Y., Tahija S.G., Dalton P.D., Constable I.J., McAllister I.L., Centre for Ophthalmology and Visual Science, Nedlands, Australia. II-498. Subconjunctival Biocompatibility of Poly Ortho Ester. Zignani M., Bernatchez S.F., Tabatabay C., Anderson J.M., Gurny R., University of Geneva, School of Pharmacy, Geneva, Switzerland. ORTHOP(r)DICS II-499. Extra-Cortical Fixation for Joint Replacements. Coathup M., Cobb J.P., Walker P.S., Unwin P.S., Blunn G.W., Royal National Orthopaedic Hospital, Biomedical Engineering, Stanmore, UK. II-500. Parametric Optimization of the Materials of a Charnley Hip Prostheses to Minimize Stress Shielding in the Proximal Bone Whilst Maximizing the Fatigue Life of the Cement. Hedia H.S., Barton D.C., Fisher J., Ibrahim A., University of Leeds, Department of Mechanical Engineering, Leeds, UK. II-501. Biomaterials In Bone Surgery - An Experimental In- Vivo and In-Vitro Study. Heller W., Wendel H.P., Kramer W., University of Tubingen, Department of Cardiovascular Surgery, Tubingen, Germany. II-502. Absorbable Fixation of First Ray Osteotomies. Hetherington V.J., DiVasto R., Pietrantoni M., Ohio College of Podiatric Medicine, Cleveland, USA. II-503. Use of Calcium Sulfate or Fresh Frozen Cortico-Cancellous Allograft to Repair 1.5 mm and 3.0 mm Cortical Defects in the Rat Femur. Huff Jr. W.L., Rodeheaver G.T., Grisoni B.F., University of Virginia, Plastic Surgery Research, Charlottesville, USA. II-504. First Clinical Experience with an Elastomer Coated Hip Stem. Jaecques S.V.N., Helsen J.A., Mattheeuws D.R.G., Simon J.P., Verhoeven G., Catholic University of Leuven, Department of Metallurgy and Materials Engineering, Leuven, Belgium. II-505. Bone Formation with a Composite Made of Bone Marrow Cells, Platelet Factors and Natural Coral. Kania R.E., Petite H., Meunier A., Hamadouche M., Sedel L., University D. Diderot, Laboratoire de Recherches, Orthopediques, Paris, France. II-506. Compatibility of a Pyrolytic Carbon/Cartilage Articulation. Kawalec J.S., Hetherington V.J., Melillo T.C., Corbin N., Case Western Reserve University, Department of Biomedical Engineering, Cleveland, USA. II-507. Corrosion Pits in Human Hip Arthroplasties. Koerten H.K., Onderwater J.J.M., Bernoski F.P., University of Leiden, Biomaterials Research Group, Laboratory of Electron Microscopy, Leiden, Netherlands. II-508. Micromotion Between the Tibial Tray and the Polyethylene Insert. Litsky A.S., Sosa M.A., Wasielewski R.C., Ohio State University , Orthopaedic Biomaterials Laboratory, Columbus, USA. II-509. The Use of Machining Parameters as a Predictor of Trabecular Bone Mechanical Properties. Vander Sloten J., Van Audekercke R., Witvrouw W., De Schutter J., K.U. Leuven Mechanical Engineering, Dept. Celestijnenlaan, Heverlee, Belgium. POLYETHYLENE II-510. High Resolution Electron Microscopic Evaluation of Polyethylene. Bhambri S., Lin S., Zimmer Inc., Warsaw, USA. II-511. The Effect of Fusion Defects on the Mechanical Properties of UHMWPE. Hamilton J.V., Wang H.C., Sung C., Johnson & Johnson Professional Inc, Raynham, USA. II-512. The Effects of the Manufacturing Process and Sterilization Technique on the Tensile Properties of Ultra-High Molecular-Weight Polyethylene. Hulbert S.F., Megremis S.J., Rose-Hulman Institute of Technology, Munster, USA. II-513. Comparison of the In-Vivo Wear Rates of 43 Surgically Retrieved Direct Compression Molded and Ram Extruded Ultra- High Molecular-Weight Polyethylene Acetabular Components. James S.P., Lee K.R., Beauregard G.P., Rentfrow E., McLaughlin J.R., Colorado State University, Department of Mechanical Engineering, Fort Collins, USA. II-514. Process Dependent Characteristics of Polyethylene. Johnson T.S., Devanathan D., Swarts D., King R., Lin S., Gsell R., Rohr W., Zimmer Inc., Warsaw, USA. II-515. Application of Cross-Linked Polyethylene as a Material for a New Finger Prosthesis. Joyce T.J., Unsworth A., University of Durham, Centre for Biomedical Engineering, Durham, UK. II-516. Long-Term Behavior of Implant Grades of Polyethylene. King R., Kirkpatrick L., Devanathan D., Lin S., Krebs S., Rohr W., Zimmer Inc., Warsaw, USA. II-517. Fatigue Crack Propagation Rates of Isostatic Pressed and Ram Extruded Ultra-High Molecular-Weight Polyethylene. Megremis S.J., Hulbert S.F., Rose-Hulman Institute of Technology, Munster, USA. II-518. Effects of Gamma Irradiation on Ultra High Molecular Weight Polyethylene Fibers. Meng D., Tian Y., Latour Jr. R.A., Shalaby S.W., Clemson University, Department of Bioengineering, Pendleton, USA. II-519. In-Vivo Advancement of Oxidation Front In Ultra-High-Molecular-Weight-Polyethylene Components. Muratoglu O.K., Bragdon C.R., Elder J.R., Jasty M., Harris W.H., Massachusetts General Hospital, Orthopaedic Biomechanics Laboratory, Boston, USA. II-520. Wear-Resistant Properties of Newly Improved UHMWPE. Oka M., Hyon S., Ikada Y., Toguchida J., Nakamura T., Kyoto University, Research Centre for Biomedical Engineering, Kyoto, Japan. II-521. Design of Experiments to Reveal Process- Property Effects in Compression Molding of Ultra High Molecular Weight Polyethylene. Ramani K., Parasnis N., Devanathan D., Purdue University, School of Mechanical Engineering, West Lafayette, USA. II-522. Effects of Antioxidant on the Tribological Properties of Gamma Sterilized Ultra High Molecular Weight Polyethylene. Ruger L.M., Love B.J., Drews M.J., Hutton W.C., LaBerge M., Clemson University, Department of Bioengineering, Clemson, USA. II-523. A Simple Accelerated Aging Method for Long Term Post-Radiation Effects in UHMWPE Implants. Sun D., Schmidig G., Stark C., Dumbleton J.H., Howmedica Inc., Rutherford, USA. POLYMERS II-524. Kinetics of Irreversible Binding of Protein on Hydrogel Contact Lenses. Garrett Q., Chatelier R., Griesser H., Milthorpe B.K., University of New South Wales, Graduate School of Biomedical Engineering, Sydney, Australia. II-525. Enzyme-Based Bioartificial Polymeric Materials. Lazzeri L., Cristallini C., Cascone M.G., Polacco G., Palla M., Barbani N., University of Pisa, Department of Chemical Engineering, Pisa, Italy. II-526. Sutures Braided from Microfibers. Liu C.K., Kokish M., United States Surgical Corporation, Materials Research and Development, North Haven, USA. II-527. Human Health Risk Assessment of 4,4'- Methylenedianiline (MDA) Released from Certain Polyurethane Medical Devices. Nestmann E.R., Lynch B., Wilson R., Daniels J., Hinberg I., Daka J., Rocheleau M.J., CanTox Inc., Mississauga, Canada. II-528. Surface Analysis of Modified Polyurethane. Otoyo T., Leach-Scampavia D., Ratner B.D., University of Washington, Department of Chemical Engineering, Seattle, USA. II-529. Conditions for Amino Acid Containing Thermo-Responsive Hydrogel Synthesis: Relationship to Gel Properties. Safrany A., Yoshida M., Omichi H., Katakai R., Institute of Isotopes-HAS, Radiation Chemistry Department, Budapest, Hungary. II-530. New Polymerizable Activators for the Preparation of Acrylic Bone Cements. San Roman J., Levenfeld B., Elvira C., Vazquez B., Pascual B., Goni I., Gurrachaga M., CSIC, Instituto de C. y T. de Polimeros, Madrid, Spain. II-531. Stability of Biomedical Grade Polyurethanes: In-Vitro Characterization. Tanzi M.C., Mantovani D., Petrini P., Guidoin R., Laroche G., Quebec Biomaterials Institute, Departments of Metallurgy and Surgery, Quebec, Canada. SURFACE MODIFICATION II-532. Reacting Composing Hap Bioceramic Coating By Laser Cladding. Jiacheng G., Yaping Z., Mingfei C., Chongqing University, Department of Metallurgy and Materials Engineering, Chongqing, China. II-533. Micro-Texturing and Selective Surface Modification of Biomedical Polymers Using Reactive Ion-Etched Silicon Substrates. Kapur R., Spargo B.J., Calvert J.M., Vargo T.G., Rudolph A.S., Code 6900 Naval Research Lab, Center for Biomolecular Science and Engineering, Washington, USA. II-534. Rapid Multicellular Spheroid Formation of Hepatocytes on a Chemically Modified Surface. Kawase M., Michibayashi N., Yoshimura Y., Yamada C., Sumiyoshi N., Yagi K., Mizoguchi T., Kagawa University, Faculty of Education, Takamatsu, Japan. II-535. Protein Adsorption Kinetics on PEO-Grafted Glass. Kidane A., Szleifer I., Park K., Purdue University, School of Pharmacy, West Lafayette, USA. II-536. In-Vitro Investigations of Corrosion Resistance of Ion-Beam Surface Modified Implant Materials. Kimura H., Ektessabi A.M., Kyoto University, Faculty of Engineering, Kyoto, Japan. II-537. Interfacial Structure Determination of Phosphatidylcholine-Grafted Silica Materials by Cold-Stage X- Ray Photoelectron Spectroscopy. Kohler A.S., Furcht L.T., University of Minnesota, Biomedical Engineering Center, Avecor Cardiovascular, Plymouth, USA. II-538. Evaluation of Actin Filaments of Fibroblasts Attached to UV-Treated Polypeptide Surfaces. Kugo K., Mizutani K., Nishino J., Konan University, Department of Applied Chemistry, Faculty of Science, Kobi, Japan. II-539. Quantitative Characterization of Surface Topography and Its Effect on Corrosion and Wear Resistance of Tin Thin Films. Kurzydlowski K.J., Warsaw University of Technology, Warsaw, Poland. II-540. Porous Calcium Deficient Hydroxyapatite Coatings on Titanium. Leamy P., Randall C.A., Brown P.W., Penn State University, University Park, USA. II-541. Reagentless Inhibition Enzyme Electrodes. Leech D., Trudeau F., Daigle F., Universite de Montreal, Montreal, Canada. II-542. Blood Compatible Surfaces Prepared by a Gas Discharge Process. Lens J.P., Terlingen G.J.A., Engbers G.H.M., Feijen J., University of Twente, Institute for Biomedical Technology, Department of Chemical Technology, Enschede, Netherlands. II-543. Influence of Gas Pressure on Calcium Phosphate Coatings Produced by Pulsed Laser Deposition. Leon B., Arias J., Mayor B., Garcia F., Pou J., Chiussi S., Perez-Amor M., Universidad de Vigo, Dpto. Fisica Aplicada, Vigo, Spain. II-544. Polymer-Immobilized Bio-Active Nonionic Detergent: Synthesis and Characterization. Liu Z., Wu X., University of Toronto, Faculty of Pharmacy, Toronto, Canada. II-545. Laser Treatment on NiTi Shape Memory Alloy. Villermaux F., Tabrizian M., Meunier M., Piron D.L., Yahia L.H., Ecole Polytechnique, Biomedical Engineering Institute, Montreal, Canada. WEAR DEBRIS II-546. Metallic Wear Debris from Periprosthetic Tissue of Failed Arthroplasty Induces TNFa and IL-1a Release from Synoviocytes. Bendall S.P., Radfar A.J., Frondoza C., Jinnah R.H., Hungerford D.S., John Hopkins University, Department of Orthopaedic Surgery, Baltimore, USA. II-547. Cytokine Production in Human Macrophages Containing Wear Debris. Campbell P., Goodman S., Song Y., O'Connor M., Huie P., Sibley R., Amstutz H., Los Angeles Orthopaedic Hospital, Joint Replacement Institute, Los Angeles, USA. II-548. A New Coculture Model of Aseptic Loosening. Chan P., Gonzales J.B., Sawyer J.R., Horowitz S.M., University of Pennsylvania, Department of Orthopaedic Surgery, Philadelphia, USA. II-549. Wear Analysis of Retrieved Acetabular Components with a Non-Thickness-Based Method. Feikes J., Wimmer M.A., Berzins A., Schneider E., Galante J.O., Technical University of Hamburg, Biomechanics Section, Hamburg, Germany. II-550. Morphology of Ultra-High Molecular Weight Polyethylene Wear Debris Isolated from a Series of Charnley Hip Arthroplasties. Hailey J., Ingham E., Wroblewski B., Stone M., Fisher J., University of Leeds, Department of Mechanical Engineering, Leeds, UK. II-551. Correlation Between Particles in Tissue and Volumetric Wear of Acetabular Components. Hirakawa K., Bauer T.W., Hashimoto Y., Stulberg B.N., Wilde A.H., Cleveland Clinic Foundation, Cleveland, USA. II-552. Does Cylic Strain Affect The In-Vitro Response of Fibroblasts and Macrophages to Particulate PMMA? Jones L.C., Frondoza C., Widra M., Sohrabi A., Hungerford D.S., Johns Hopkins University, Department of Orthopaedic Surgery, Baltimore, USA. II-553. Distinguishing Between Artifact and Polyethylene Particles Generated In-Vivo. Lalor P.A., Meuten D.J., DeYoung D.J., Aberman H.A., Howmedica Inc., Division of Pfizer Hospital , Products Group, Rutherford, USA. II-554. Human Serum and Particulate Debris: Protein Binding and Macrophage Activation. Nakashima Y., Maloney W.J., Goodman S.B., Sun D.H., Smith R.L., Stanford University Medical Center, Orthopaedic Research Laboratory, Stanford, USA. ___________________________________________________________ Friday, May 31: Oral Session 5 2:30-3:30 METALS I Room 206A/B Chairs: P. Ducheyne, J.C. Shelton 2:30 I-555. Insights into Passive Dissolution of Titanium In-Vitro. Liu C., Burstein G.T., University of Cambridge, Dept. of Materials Science and Met., Cambridge, UK. 2:45 I-556. Multiaxial Fatigue Testing of Medical Grade Titanium Alloy. McDougall I., Gregson P.J., Shelton J.C., University of London, Queen Mary & Westfield College, IRC in Biomedical Materials, London, UK. 3:00: I-557. Bioactivity of H2O2 Treated Ti and Ti Alloys. Osaka A., Ohtsuki C., Iida H., Hayakawa S., Okayama University, Faculty of Engineering, Biomaterials Division, Okayama-shi, Japan. 3:15: I-558. Influence of Serum Proteins on the Mechanical and Corrosive Damage to Fretted Ti6Al4V Surfaces. Smith B., Ducheyne P., University of Pennsylvania, Department of Bioengineering, Philadelphia, USA. CARDIOVASCULAR I Room 206C/D Chairs: F. Schoen, K. Tweden 2:30 I-559. Thrombogenicity of Catheters in Human: 1. In-Vivo Study and Physico Chemical Characterization. Bailly A.L., Laurent A., Lautier A., Guiffant G., Dufaux J., Merland J.J., DRC/DPIM AP-HP, Paris, France. 2:45 I-560. Fibronectin Enhances Cell Spreading and Retention on ePTFE Under Shear In-Vitro. du Laney T.V., Truskey G.A., Klitzman B., Duke University, Center for Biochemical Engineering, Durham, USA. 3:00: I-561. Development of a D Dimer Biosensor to Monitor Stroke Patients During Thrombolytic Therapy. Grant S.A., Glass R.S., Lawrence Livermore National, Laboratory, Livermore, USA. 3:15: I-562. Covalent Immobilisation Of Cell Adhesion Mediators on Polymer Surfaces to Promote Endothelial Cell Seeding. Klee D., Lorenz G., Wirsching J., Bienert H., Dekker A., Hocker H., Mittermayer C., RWTH Aachen, Department of Textile and, Macromolecular, Aachen, Germany. Polymer Modification POLYMER MODIFICATION Room 206E/F Chairs: A. Hiltner, J. Kohn 2:30 I-563. Canine Intramedullary Bone Response to Tyrosine-Derived Polycarbonates. Choueka J., Alexander H., Charbet J.L. , Koval K.J., Green W.S., Hooper K.A., Ertel S.I., Hospital for Joint Diseases, New York, USA. 2:45 I-564. Modification of Polyetheretherketone for Biomedical Applications. Ha S.W., Kirch M., Birchler F., Wintermantel E., ETH Zurich, Schlieren, Switzerland. 3:00: I-565. New Poly(ether-carbonate-amide)s Containing Tyrosine Derivatives and PEG Exhibit Inverse Temperature Transitions and Useful Engineering Properties. Kohn J., Yu C., Rutgers University, Department of Chemistry, Piscatoaway, USA. 3:15: I-566. Vitamin E as an Additive in Poly(Etherurethane Urea): In-Vivo Studies. Schubert M.A., Wiggins M.J., DeFife K.M., Hiltner A., Anderson J.M., Case Western Reserve University, Department of Macromolecular , Science, Cleveland, USA. ORTHOP(r)DICS: HYDROXYAPATITE Room 104A/B Chairs: K. deGroot, C. van Blitterswijk 2:30 I-567. Bone Ingrowth into Porous and HA Coated Titanium Implants in Experimental Inflammatory Arthritis. Friedman R.J., An Y.H., Jiang M., Butehorn III H.F., Draughn R.A., Bauer T.W., Medical Univ. of Southern Carolina, Department of Orthopaedic Surgery, Charleston, USA. 2:45 I-568. Activation of Titanium for Bonding with Bone: I. Induction of Carbonated Hydroxyapatite In-Vitro. Li P., Ducheyne P., University of Pennsylvania, Department of Bioengineering, Philadelphia, USA. 3:00: I-569. The Migration of Cups After Total Hip Replacement PE vs HA-Coated and Ti-Coated. Muller-Mai C., Pawelz B., Fell M., Paech A., Gross U., Rahmanzadeh R., Free University of Berlin, University Hosp. Benjamin Franklin, Berlin, Germany. 3:15: I-570. A Comparative Evaluation of Dense Hydroxyapatite Implants and Hydroxyapatite- Coated Implants: Results of Stress Loading in Dogs. Ogiso M., Yamashita Y., Lee R.R., Borgese D., Matsumoto T., Tokyo Medical and Dental University, Faculty of Dentistry, Tokyo, Japan. ENCAPSULATION Room 104C Chairs: M. Sefton, K. Kalauka 2:30 I-571. Novel Drug Carrier of Thermo- Responsive Polymeric Micelle Composed of Poly(N-Isopropylacrylamide)-Based Block Copolymer. Aoyagi T., Suzuki K., Cammas S., Kataoka K., Sakurai Y., Okano T., Tokyo Women's Medical College, Institute of Biomedical Engineering, Tokyo, Japan. 2:45 I-572. A Novel Immuno-Isolative Membrane Applicable for Islet Xenograft. Iwata H., Morikawa N., Ikada Y., Kyoto University, Research Center for Biomedical, Engineering, Kyoto, Japan. 3:00: I-573. Microencapsulation of Genetically Engineered Cells in a Hema-MMA Copolymer. Lahooti S., Horvath V., Sefton M.V., University of Toronto, Department of Chemical Engineering, & Applied Chemistry, Toronto, Canada. 3:15: I-574. Characterization of Taxol-Loaded Poly(L-lactic Acid) Microspheres for Intra- Articular Injection. Liggins R., Gabana C.A., Cruz T., Burt H.M., University of British Columbia, Faculty of Pharmacuetical Sciences, Vancouver, Canada. SURFACE ANALYSIS Room 104D Chairs: R. Sodhi, H.J. Griesser 2:30 I-578. Albumin Adsorption on Hard Tissue Replacement Biomaterials. Zeng H., Chittur K.K., Lacefield W.R., University of Alabama, Department of Biomaterials, Birmingham, USA. 2:45 I-576. TOF-SSIMS and XPS Study of Soft Contact Lens Fouling - In-Vitro. Kingshott P., St. John H.A.W., Bolis S., Chatelier R.C., Griesser H.J., CSIRO, Division of Chemicals and Polymers, Clayton, Australia. 3:00: I-577. Adsorbed Protein Configuration and Orientation Probed by ESCA and Time-of- Flights SIMS. Ratner B., Tidwell C.D., Meyer K., Castner D.G., Golledge S., Hagenhoff B., Benninghoven A., University of Washington, Department of Chemical Engineering, Seattle, USA. 3:15: II-204 Surface Dynamic Properties of Biomedical Anionic Polymers. Chen W., Gao W., Wu P.Q., Wu C., Qiang D., Peking University, College of Chemistry, Institute of Polymer Chemistry, Beijing, China [Note: Replaces I-575. *Withdrawn* The Effect of Radio-Frequency Glow Discharge Treatment on the Sterility and Surface Changes of Dental Implant Drills. DeGrado J.D., Cranin A.N., Baraoidan M., Sayed A., Brookdale Hospital, Dental Implant Group, Brooklyn, USA. ] ___________________________________________________________ Friday, May 31: Oral Session 6 4:00-5:30 JOINT TRIBOLOGY I Room 206A/B Chairs: J. Dumbleton, J. Fisher 4:00: I-579. The Influence of Temporal and Spatial Variations In Stress on the Wear of UHMWPE for Total Joint Prostheses. Barbour P.S.M., Barton D.C., Fisher J., University of Leeds, Department of Mechanical , Engineering, Leeds, UK. 4:15: I-580. A Simulator for the Evaluation of Total Knee Replacement Wear. Essner A., Wang A., Stark C., Dumbleton J.H., Howmedica Inc., Division of Pfizer Hospital, Products Group, Rutherford, USA. 4:30: I-581. The Influence of Femoral Material Manufacturing Technique and Surface Topography on the Wear of UHMWPE in Total Joint Replacement. Lancaster J., Dowson D., Fisher J., University of Leeds, Leeds, UK. 4:45: I-582. The Importance of Multidirectional Motion for the Wear of Polyethylene in the Hip. O'Connor D.O., Bragdon C.R., Lowenstein J.D., Syniuta W.D., Advanced Mechanical Technology Inc., Watertown, USA. 5:00: I-583. Wear Testing Based on Undirectional Motion: Fact or Artifact? Wang A., Sun D.C., Stark C., Dumbleton J.H., Howmedica Inc., Division of Pfizer Hospital , Products Group, Rutherford, USA. 5:15: I-584. Boundary Lubricating Elastomer for Physiological Bearing Applications II. Friction Tests. Williams III P.F., Gilbert J.A., Powell G.L., Ishihara K., Nakabayashi N., LaBerge M., Mississippi State University, Department of Agriculture and, Biological Engineering, USA. CARDIOVASCULAR II Room 206 C/D Chairs: W. Wagner, P. Didischeim 4:00: I-585. Absorbable Stents: Material Selection and Deformation Behaviour. Behrend D., Schmitz K.P., Martin H., Schmidt W., Schaffer J., Urbaszek W., University of Rostock, Institute of Biomedical Engineering, Germany. 4:15: I-586. Development of a New Sealing Method Without Foreign Body Reaction for Porous Vascular Prostheses. Noishiki Y., Ma X.H., Tomizawa Y., Yamane Y., Doulet M., Takahashi K., Iwai Y., Yokahama City University, Yokohama, Japan. 4:30: I-587. A Synthetic Photopolymerized Biodegradable Hydrogel for Sealing Arterial Leaks. Sawhney A., Moody E.W., Levine M.A., Rudowsky R., Focal Inc., Lexington, USA. 4:45: I-588. Bone Marrow Transplanted Vascular Prosthesis For Rapid Endothelialization. Tomizawa Y., Noishiki Y., Yamane Y., Okoshi T., Nishida H., Endo M., Koyanagi H., Tokyo Women's Medical College, Department of Cardiovascular, Surgery, Tokyo, Japan. 4:45: I-589. Vessel Healing Response to Bioabsorbable Implant. Yaklavich M.F., Thatcher G.L., Sasken H.F., Cordis Corporation, Miami, USA. 5:15: I-590. Development of a Digitally-Monitored High Flow Rate System for Embolic Materials Testing Used in Arteriovenous Malformation Therapy. Zambo S.J., Gage K.L., Rogers E.S., Batich C.D., University of Florida, Deparment of Materials Science, and Engineering, Gainesville, USA. TISSUE RESPONSE I Room 206 E/F Chairs: D. Williams, J. Jansen 4:00: I-591. Animal Study of Soft Tissue Behaviour to Microgrooved Implants. den Braber E., de Ruijter J., Jansen J., University of Nijmegen, Dept. of Cell Biology and Histology, Lab. of Biomaterials, Nijmegen, Netherlands. 4:15: I-592. Effect of Fluoride Conditioning of Ti on the Bone Response. Ellingsen J.E., Birkeland G., Loga K.M., University of Oslo, Department of Prosthetic Denistry, Oslo, Norway. 4:30: I-593. Hydrophillicity of Polymers and Soft Tissue Responses: A Quantitative Analysis. Hunt J., Meijs G., Williams D.F., University of Liverpool, Clinical Engineering, Liverpool, UK. 4:45: I-594. An Experimental Rabbit Model for the Study of Implant Healing in Onlay Grafts. Mohammadi S., Rasmusson L., Goransson L., Sennerby L., Thomsen P., Kahnberg K.E., Institute of Anatomy & Cell Biology, Goteborg, Sweden. 5:00: I-595. Soft Tissue Reaction Around Percutaneous Devices. Paquay Y.C.G.J., de Ruijter A.E., van der Waerden J.P.C.M., Jansen J.A., University of Nujmegen, Laboratory of Biomaterials, Nijmegen, Netherlands. 5:15: I-596. Mechanisms of Ni-Induced Inflammation in Connective Tissue. Wataha J.C., Sun Z.L., Fang D.N., Hanks C.T., Medical College of Georgia, School of Dentistry, Augusta, USA. BONE-MATERIAL INTERACTIONS II Room 104A/B Chairs: B. Broxup, C. Larssun 4:00: I-597. Surface Energy Effects on Osteoblast Attachment: A Model System. Scotchford C., Sim B., Hutt D., Leggett G., Downes S., University of Nottingham, Queen's Medical Centre, Department of Human Morphology, Nottingham, UK. 4:15: I-598. Different Effects of Particles During Bone Ingrowth and Remodeling. Goodman S.B., Aspenberg P., Song Y., Doshi A., Regula D., Lidgren L., Stanford University, Medical Center, Stanford, USA. 4:30: I-599. Study of the Bone/NiTi Interface Using Immunohistochemistry. Gorbet M., Rivard C., Yahia L.H., Broxup B., University of Toronto, Centre for Biomaterials, Toronto, Canada. 4:45: I-600. Isolation of the Cement-Line Bone Interface In-Vitro. Hosseini M.M., Todescan R., Davies J.E., University of Toronto, Centre for Biomaterials, Toronto, Canada. 5:00: I-601. The Bone Response to Threaded and Non-Threaded Titanium Implants in Rats. Larsson C., Toft U., Thomsen P., University of Goteborg, Department of Anatomy, and Cell Biology, Goteborg, Sweden. 5:15: I-602. A New Approach to Quantification of Bone Healing and Mineralization in Defects and Around Calciumphosphate-Coated Implants. Plenk H., Grossschmidt K., Roschger P., Watzek G., University of Vienna, Histol. Enbryol. Inst., Dept. of Bone and Biomat. Res., Vienna, Austria. INFECTION II Room 104C Chairs: S. Cooper, C. Doillon 4:00: I-603. Gas Plasma Treatment of Implant Materials: 10-Year Summary of Progress. Baier R.E., Meyer A.E., Stachowski M.J., Carter L.C., Taha E.K., Carter J.M., Vargas E., State University of New York, Industry/ University Center for , Biosurfaces, Buffalo, USA. 4:15: I-604. Chemical Treatments of Bovine Collagen Materials to Eliminate Infectivity. Doillon C., Drouin R., Cote M.F., Daillaire N., Pageau J.F., Laroche G., Hopital Saint- Francois d'Assise, Institut des biomateriaux E0-178, University Laval, Quebec, Canada. 4:30: I-605. Substratum Control of Antibiotic Release from Biomaterials. Kwok C., Horbett T.A., Wan C., Shen L., Ratner B.D., University of Washington, Department of Chemical Engineering, Seattle, USA. 4:45: I-606. Bacterial Biofilms. Pitt W., Qian Z., Sagers R., Brigham Young University, Provo, USA. 5:00: I-607. Bio-Integration and Infection Resistance of Materials: Micropig and Ovine Evaluation. Ramasamy N., Morton L., Seare W., Greenberg S., Stout R., Marchand G., Green B.A., Baxter Healthcare Corporation, Novacor Division, Oakland, USA. 5:15: I-608. Polymorphonuclear Leukocyte Adhesion Under Shear Stress on Poly(Etherurethane Ureas) in the Presence of Staphylococcus Epidermidis. Sapatnekar S., Kao W.J., Anderson J.M., Case Western University, Institute of Pathology, Dept. of Biomedical Engineering, Cleveland, USA. POLYURETHANES Room 104D Chairs: P. Santerre, K. Ishihara 4:00: I-609. In-Vitro Macrophage Mediated Oxidation and Stress Cracking in a Polyetherurethane. Casas-Bejar J.W., Zhao Q., Unterecker D.F., Medtronic Inc., Center for Biomaterials Research, Minneapolis, USA. 4:15: I-610. Immobilized Heparin and Heparin- Bisphosphonate Prevent Polyurethane Calcification and Thrombosis: In-Vitro and In-Vivo Studies. Joshi R.R., Frautschi J.R., Phillips Jr. R.E. , Levy R.J., University of Michigan, Medical Center, Dept of Pediatrics & Cardiology, Ann Arbor, USA. 4:30: I-611. Function and Stability of Surface Modifying Macromolecules used to Inhibit the Hydrolytic Biodegradation of Polyurethanes. Tang Y., Santerre J., Lee A., Lim R., Labow R., University of Toronto, Faculty of Dentistry, Department of Biomaterials, Toronto, Canada. 4:45: I-612. Biodegradation of a Polyurethane by Cholesterol Esterase and Analysis of Related Degradation Products. Wang F., Santerre J., Labow R., University of Toronto, Faculty of Dentistry, Department of Biomaterials, Toronto, Canada. 5:00: I-613. Effect of Polyethylene Glycol Spacers on the Function of Surface Modifying Macromolecules for the Inhibition of Polyurethane Biodegradation. Weiler L., Santerre J., Labow R., University of Toronto, Faculty of Dentistry, Toronto, Canada. 5:15: I-614. In-Vitro Formation of Hydroperoxides in Polyetherurethane Biodegradation. Zhao Q., Casas-Bejar J., Hobot C.M., Untereker D.F., Medtronic Inc., Center for Biomaterials Research, Minneapolis, USA. ___________________________________________________________ Saturday, June 1: Oral Session 7 8:30-10:30 BIOMECHANICS Room 206A/B Chairs: W.J. Merguel, K. Thompson 8:30: I-615. Collagen Fiber Mobility Under Biaxial Stretch. Billiar K.L., Sacks M.S., Singh G., Thompson K., University of Miami, Dept. of Biomedical Engineering, Coral Gables, USA. 8:45: I-616. The Mechanical Properties of Vertebrae: An Evaluation of The Mature Ovariectomized Rat Model of Post- Menopausal Osteoporosis. Chachra D., Kasra M., Lee J.M., Grynpas M.D., University of Toronto, Centre for Biomaterials, Toronto, Canada. 9:00: I-622. Testing of Ionometric Bone Bond in Rabbit Mini-Pig and Baboon. Schmitz H.J., Langer O., Arent J., Aachen University, Department of Oral/Maxillofacial and Facial Surgery, Aachen, Germany. 9:15: I-618. Biomechanical Evaluation of Pull-Out Strength of the Anchor Screws for the AO Anterior Cervical Spine Locking Plate. Mitchell D.W., Betcher R., Littlejohn S., Dillon L., McGuire R., Zardiackas L., University of Mississippi Medical Center, Jackson, USA. 9:30: I-619. The Effects of Laser Energy on the Shoulder Ligament. Park S.H., Bresch J.R., Shields C.L., University of Southern California, Orthopaedic Hospital, Los Angeles, USA. 9:45: I-620. Biaxial Mechanical Behaviour of Fixed Bovine Pericardium. Sacks M.S., University of Miami, Dept. of Biomedical Engineering, Coral Gables, USA. 10:00 I-621. Viscoelastic Behavior of Human Atherosclerotic Plaque. Salunke N.V., Topoleski L.D.T., Mergner W.J., University of Maryland, Department of Mechanical, Engineering, Baltimore, USA. 10:15 I-617. Mechanical Properties and Structural Analysis on Apatite-Collagen Complex. Fujii K., Tanaka J., Nishihara K., National Institute for Research in Inorganic Materials, Ibaraki, Japan. [*Withdrawn*] CALCIUM PHOSPHATE Room 206C/D Chairs: S. Vallabhaneni, T.G. Nieh 8:30: I-623. In-Vitro Calcium Phosphate Formation on Surface-Phosphonylated Polyethylene. Campbell C.E., Nelson A.M., Hudson J.S., von Recum A.F., Shalaby S.W., Clemson University, Department of Bioengineering, Clemson, USA. 8:45: I-624. Immuno-SEM Localization of Osteopontin Adsorption to Individual Faces of Calcium Phosphate Crystals and Ceramic Grains. Peru L., Davies J.E., University of Toronto, Centre for Biomaterials, Toronto, Canada. 9:00: I-625. Fatigue Behaviour of Calcium Phosphate Coatings: Effect of Crystallinity and Test Conditions. Clemens J., Wolke J.G.C., Rozing P.M., de Groot K., Leiden University, Biomaterials Research Group, Bilthoven, Netherlands. 9:15: I-626. Fibronectin Evidence During Biological Apatite Precipitation from Calcium Phosphate Ceramic an HR TE EM Study. Daculsi G., Pilet P., Faculte de Chirurgie Dentaire, Lab. de Recherche sur les tissus, Nantes, France. 9:30: I-627. Synthetic Calcium Phosphate-Based Skeletons. Luo P., Genin F.Y., Nieh T.G., Lawrence Livermore National, Laboratory, Livermore, USA. 9:45: I-628. Calcium Phosphate Formation from Calcium Loaded Lipid Vesicles. Messersmith P.B., Nguyen V.M., Vallabhaneni S., University of Illinois at Chicago, Department of Restorative Dentistry, Chicago, USA. 10:00 I-629. Bioactive and Porous Metal Calcium Phosphate Coatings for Improved Bone Regeneration. Campbell A.A., Graff G.L., Fryxell G.E., Song L., Sump K.W., Miller G.J., Wheeler D.L., Pacific Northwest National Lab., Richland, USA. 10:15 I-630. In-Vivo Dissolution Behavior of Various RF Magnetron Sputtered Ca-P Coatings. Wolke J.G.C., de Groot K., Jansen J.A., University of Nijmegen, Department of Oral Function, Dental School, Nijmegen, Netherlands. SURFACE MODIFICATION: POLYMERS Room 206E/F Chairs: Y.H. Kim, B.D. Ratner 8:30: I-631. Cytocompatibility of Surface Conducting Polymers. Allan J.M., Pearce F.J., Gregory R.V., van Kooten T., Shalaby S.W., Clemson University, College of Engineering & Sciences, Engineering Resource Center, Clemson, USA. 8:45: I-632. Surface Rearrangement of Hydrophilic/ Hydrophobic Block Copolymers Containing Poly (2 3-Dihydroxyprop yl Methacrylate). Castner D.G., Radner B.D., Senshu K., Hirao A., Nakahama S., University of Washington, Department of Chemical Engineering, Seattle, USA. 9:00: I-633. Grafting PMMA on Hydroxylapatite Powder Particles Using Isocyanato- ethylmethacrylate. de Wijn J.R., Liu Q., Blitterswijk C.A., University of Leiden, Biomaterials Research Group, Bilthoven, Netherlands. 9:15: I-634. Compositional Changes on Storage of Polymeric Biomaterial Surfaces Prepared by RF Glow Discharges. Gengenbach T.R., Li S., Chatelier R.C., Griesser H.J., CSIRO, Division of Chemicals and Polymers, Clayton, Australia. 9:30: I-635. On the Stability of (Gas) Plasma Oxidized Polymer Surfaces. Terlingen J., Takens G.A.J., Engbers G.H.M., Feijen J., University of Twente, Dept. of Chemical Technology, Enschede, Netherlands. 9:45: I-636. Bound Polymer Thin Films Enriched in Grafted Chains. Castner D., Wang W., Grainger D.W., University of Washington, Department of Chemical Engineering, Seattle, USA. 10:00 I-637. Surface Modification of Bioresorbable Polymers by Plasma Induced Graft Polymerization. Thissen H., Klee D., Bartsch G., vom Dahl J., Bienert H., Hanrath P., Hocker H., Department of Macromolecular &, Textile Chemistry, Aachen, Germany. 10:15 I-638. Surface Grafting onto Vinyl Amine Copolymer: Approach for Double Layered Microcapsules. Yamamoto Y., Sefton M.V., University of Toronto, Department of Chemical Engineering, Toronto, Canada. DRUG DELIVERY II Room 104A/B Chairs: Y. Ikada, N. Peppas 8:30: I-639. Functional Recovery Using Cross- Linked Collagen Tubulization for Neurotrophic Factor Delivery in a Rat Peripheral Nerve Model. Kloss J.M., Utley D.S., Terris D.J., Sierra D.H., Cohesion Corporation, Palo Alto, USA. 8:45: I-640. The Controlled Release of Macromolecules from Poly (phosphazene) Matrices. Laurencin C.T., Ibim S.M., Ambrosio A., Larrier D., Allcock H., Medical College of Pennsylvania, Hospital, Department of Orthopaedic Surgery, Philadelphia, USA. 9:00: I-641. Use of a Self-Assembling Bicontinuous Cubic Phase for the Controlled Release of Proteins: Hemoglobin in Monooleoylglycerol. Leslie S., Puvvata S., Ratna B.R., Rudolph A.S., Code 6900 Naval Research Lab, Center for Biomolecular Science, and Engineering, Washington, USA. 9:15: I-642. Regulated Peptide Release from Biodegradable Polysaccharide Hydrogels Containing Poly(Ethylene Glycol). Moriyama K., Yui N., Japan Advanced Institute of Science and Technology, Ishikawa, Japan. 9:30: I-643. Mucoadhesive PVA Hydrogels for Release of Wound Healing Drugs. Peppas N., Anseth K.S., Mongia N.K., Purdue University, School of Chemical Engineering, West Lafayette, USA. 9:45: I-644. Hydroxyapatite Surface Layer Formation on Glass Xerogels Used for the Controlled Release of Biological Molecules. Santos E.M., Radin S., Ducheyne P., University of Pennsylvania, Department of Bioengineering, Philadelphia, USA. 10:00 I-645. Interfacially Photopolymerized Hydrogels for Local Vascular Drug Delivery. West J.L., An Y., Hubbell J.A., California Institute of Technology, Division of Chemistry and, Chemical Engineering, Pasadene, USA. BLOOD-MATERIAL INTERACTIONS II Room 104C Chairs: T. Matsuda, T. Horbett 8:30: I-646. Adsorption of Proteins to Hemodialysers: Comparison of Plasma and Whole Blood In-Vitro Studies. Cornelius R., Molnar A., Brash J.L., McMaster University, Department of Chemical Engineering, Hamilton, Canada. 8:45: I-647. Material-Induced Platelet Activation in a Canine Model: Reduced Platelet Life Span and Elevated Microparticle Levels. Gemmell C., Lo C., Yeo E.L., Sefton M.V., Toronto Hospital, Toronto, Canada. 9:00: I-648. Neutrophil Activation by Commercial Biomaterials: Effects of Albumin Preadsorption and Complement Activation. Gorbet M., Yeo E.L., Sefton M.V., University of Toronto, Department of Chemical Engineering, & Applied Chemistery, Toronto, Canada. 9:15: I-649. Poly(Ethylene Glycol) Enriched Surface: Reduced vs Delayed Protein Adsorption and Activation. Kulik E., Fouache B., Cahalan L., Verhoeven M., Hendriks M., van de Vight M., Cahalan P., Medtronic Bakken Research Center, Maastright, Netherlands. 9:30: I-650. Comparative In-Vitro Analysis of Topical Hemostatic Biomaterials. Pachence J., Wagner W.R., Ristich J., Johnson P.C., Bio Implant Technologies Corp, Hopewell, USA. 9:45: I-651. Three-Dimensional Model of Adsorbed Von Willebrand Factor Using Atomic Force Microscopy and Mathematical Morphology. Siedlecki C., Lestini B.J., Eppell S.J., Kottke-Marchant K., Wilson D., Marchant R.E., Case Western Reserve University, Dept. of Biomedical Engineering, and Macromolecular Science, Cleveland, USA. 10:00 I-652. Characterization of Poly(ether- urethane) Surfaces Photochemically Modified with Phosphorylcholine-Containing Aryl Azides. van der Heiden A.P., Koole L.H., BIOPRIME, Maastricht, Netherlands. 10:15 I-653. Leukocyte-Extracellular Matrix and Coagulation Protein Interactions on Biomaterials. Ziats N.P., Yun J.K., Anderson J.M., Shah S., Case Western Reserve University, Institute of Pathology, Cleveland, USA. IMPLANT RETRIEVAL Room 104D Chairs: A. von Recum, A. Rose 8:30: I-654. The Ingress of Particle-Induced Granulomas into the Bone-Implant Interface of Cementless Acetabular Components Retrieved at Autopsy. Urban R.M., Jacobs J.J., Sapienza C.I., Hall D.J., Infanger S., Sumner D.R., Berzins A., Rush-Presbyterian-St. Luke's, Medical Center, Department of Orthopaedic Surgery, Chicago, USA. 8:45: I-655. Wear and Oxidation of Ultra High Molecular Weight Polyethylene. Bell C., Abeysundera M., Walker P.S., Blunn G.W., Royal National Orthopaedic Hospital, Biomedical Engineering, Stanmore, UK. 9:00: I-656. Implant Retrieval - A Multi Centre Multidisciplinary Study. Gross U., Boyde A., Hahn M., Labey L., Merolli A., Meunier A., Revell P.A., University of London, Queen Mary & Westfield College, IRC in Biomedical Materials, London, UK. 9:15: I-657. Analysis of Osteoclast-Mediated Bone Resorption in Hip Prosthesis: Human Retrieved and In-Vitro Study. Kim K., Umehara S., Hijikata H., Itoh T., Tokyo Women's Medical College, Department of Orthopaedic Surgery, Tokyo, Japan. 9:30: I-658. Quantification of the Number of Polyethylene Wear Particles in Total Joint Replacments. Kobayashi A., Bonfield W., Kadoya Y., AL-Saffar N., Yamac T., Scott G., Freeman M., Royal Free Hosp. School of Medicine, Department Histopathology, Osteoarticular Research Group, London, UK. 9:45: I-659. Evaluation of Tissue Adjacent to Clinically Failed Implants. Tucci M., Tsao A., Hughes J., University of Mississippi, Medical Center, Department of Orthopaedics, Jackson, USA. 10:00 I-660. Dissemination of Metal-Alloy Particles to the Liver and Spleen of Patients With Total Hip or Knee Replacement Prostheses. Urban R., Jacobs J.J., Gavrilovic J., Tomlinson M.J., Black J., Turner T.M., Galante J.O., Rush-Presbyterian-St. Luke's, Medical Center, Department of Orthopaedic Surgery, Chicago, USA. 10:15 I-661. 3-Dimensional Analysis of Multiple Wear Directions in Retrieved Acetabular Cups. Yamaguchi M., Bauer T.W., Hashimoto Y., Cleveland Clinic Foundation, Cleveland, USA. ___________________________________________________________ Saturday, June 1: Keynote Session 11:00-12:00 Grand Ballroom 11:00 Keynote Lecture Lars Bjursten Department of Anatomy and Cell Biology, University of Goteborg, Sweden ÒThe Importance of Macrophages, Cytokines, and Some Materials Factors for the Soft Tissue Response to ImplantsÓ Chair: J.M. Anderson 11:30 Keynote Lecture Teruo Okano Institute of Biomedical Engineering, Tokyo Women's Medical College, Department of Chemistry, Faculty of Science and Technology, Sophia University, Japan ÒMolecular Design of Stimuli Responsive Polymers and their Medical/Biotechnology ApplicationsÓ Chair: A.S. Hoffman ___________________________________________________________ Saturday, June 1: Poster Session 3 1:00-2:30 BIOCERAMICS II-662. In-Vivo Biostability of a Solution Precipitated Calcium Phosphate Coating. Aberman H.M., Goodman S.B., Lalor P.A., Fagan M., Dumbleton J.H., Howmedica Inc., Division of Pfizer Hospital, Products Group, Rutherford, USA. II-663. Fabrication and Characterization of Hot Pressed Hydroxyapatite for a Radio Frequency Magnetron Sputtering Target. Brasell J.P., Rigney E.D., University of Alabama, Department of Materials and Mechanical Engineering, Birmingham, USA. II-664. Ceralique: A New Injectable Calcium Phosphate Bioceramic for Bone Filling. Daculsi G., Interdisciplinary Center for Calcified Tissue and Biomaterials, Faculte de Chirurgie Dentaire, Nantes, France. II-665. Porous Bioactive Glass and Hydroxyapatite Affect Bone Cell Function In-Vitro Along Different Time Lines. El-Ghannam A., Ducheyne P., Shapiro I.M., Desmos Inc., San Diego , USA. II-666. Piezoelectric Bioceramic HABT Promotes Osteogenesis: Phenomenon and Mechanism. Feng J., Yuan H., Zhang X., Sichuan Union University, Institute of Materials Science and Technology, Sichuan, China. II-667. An Investigation of Bone Mineral Chemistry in Mice of Different Ages. Grew J.C., Blumenthal N.C., Betts F., Tonna E.A., Jersey State College, Department of Biology, Jersey City, USA. II-668. Comparison of Bone Growth on Calcium Phosphate Coated and Uncoated Substrata In- Vitro. Lowenberg B., Todescan R., Shiga A., Yakubovich R., Glover S., Girard P., Davies J.E., University of Toronto, Centre for Biomaterials, Toronto, Canada. II-669. Novel Synthesis of Mg-Containing Biphasic Calcium Phosphates. Sampath Kumar T.S., Sivakumar M., Panduranga Rao K., University of Madras, Department of Nuclear Physics and Materials Science Centre, Madras, India. II-670. Thermal Wave Thickness Measurements of Hydroxyapatite Coatings. Turner I.G., Bento A.C., Brown S.R., Almond D.P., University of Bath, School of Materials Science, Bath, UK. II-671. Injectable Bioglass for Soft Tissue Augmentation: (Part 1) Preliminary Study. Wilson J., Proctor D.C., Elsberg L., Brownlee R.E., Bioglass Research Center, Alachua, USA. BIOCOMPATIBILITY II-672. In-Situ Hybridization Technique to Detect Biomaterial-Induced DNA Damage. Assad M., Lemieux N., Rivard C.H., Ste Justine Hospital, Research Centre, Montreal, Canada. II-673. Cytokines Localization in the Fibrous Tissue Surrounding Ceramic Implants in Animals and Humans. Benghuzzi H.A., Tucci M., Tsao A., Hughes J., University of Mississippi Medical Center, Department of Orthopaedics, Jackson, USA. II-674. Comparative Properties and In-Vivo Performance of Two Preparations of BCP. Bouler J.M., LeGeros R.Z., Daculsi G., Centre de Recherche sur les Tissus Calcifies et les Biomateriaux, Nantes, France. II-675. Mutagenicity Evaluation of Ti-15Mo Alloy. Disegi J.A., Prezioso J.A., Synthes USA, Paoli, USA. II-676. Cellular Response to Heterogeneously Charged Polymers. Kapur R., Picciolo G.L., Black J., Georgetown University, Center for Biomolecular Science and Engineering, Washington, USA. II-677. Muscle and Bone Response in the Rabbit to a Bioactive Glass Designed for Metal Coating. Merolli A., Tranquilli-Leali P., Gabbi C., Locardi B., Palmacci O., Cacchioli A., Universita Cattolica, Clinica Ortopedica, Roma, Italy. II-678. Hematologic Effects of the Davol Autotransfusion Device in Re-Operative Cardiac Surgery. Rubens F.D., Labow R.S., Robblee J.A., University of Ottawa Heart Institute, Ottawa Civic Hospital, Ottawa, Canada. II-679. Cytotoxicity of Metal Salts and Its Mixed Effects. Yamamoto A., Honma R., Sumita M., National Research Institute for Metals, Science and Technology Agency, Ibaraki, Japan. II-680. The Interface Strengthening of Apatite- Ti(Alloy) Biocomposites. Zhixiong Y., Shaoxia Z., Chinese Academy of Sciences, Shanghai Institute of Ceramics, Shanghai, China. BIOMECHANICS II-681. Interfacial Interactions of Rat Cortical Bone of Varying Age. Abjornson C., Walsh W.R., Guzelsu N., UMDNJ, Biomechanics Department, Piscataway, USA. II-682. Effect of Different Vitamin K Diets on Mechanical Properties of Rat Bones. Chevrefils C., Boudreault F., Yahia L.H., Ferland G., Ecole Polytechnique de Montreal, Institut de genie biomedical, Montreal, Canada. II-683. A Fourier Analysis of Relaxation in the Cervical Spine. Fang J., Holmes A.D., Peking University, Department of Mechanics and Engineering Science, Beijing, China. II-684. Effect of Transcortical Screws on the Torsional Properties of Bone. Goode J.S., Gharpuray V.M., Riddle Jr. C.D., Shalaby S.W., FDA, Office of Device Evaluation, DGRD/ORDB, Rockville, USA. II-685. Tibio-Femoral Contact Stress Distribution: Assessments Using Fuji Film and FEA. Hastings R.S., Tomaszewski P.R., Huston D.E., DePuy Inc., Warsaw, USA. II-686. Perspectives on Morse Taper Performance in THA. Jani S., Sauer W.A., Kovacs P., Smith and Nephew Richards Inc., Memphis, USA. II-687. Rotational Constraint of Total Knee Arthroplasties. Keane M.S., Crosett L.S., Running D.E., Hastings R.S., Wasielewski R.C., Donaldson T.K., DePuy Inc., Warsaw, USA. II-688. Distal Design of a Cemented Femoral Hip Stem Component. Kelly W.J., Bushelow M., Dudasik M.W., Poggie M.P., Howmedica Inc., Division of Pfizer Hospital, Products Group, Rutherford, USA. II-689. Predicting The Knotting Performance of Surgical Sutures. King M.W., Hong T., Guzman R.P., Guidoin R., University of Manitoba, Department of Clothing and Textiles, Winnipeg, Canada. II-690. Biomechanical Properties of Human Plasma Derived Fibrin Sealants. Nowotarski M., Rudnicka K., Michel D., Brodniewicz T., Haemacure Corp., Kirkland, Canada. II-691. Automated Identification of Zones of Criticality for Complex Biomaterial Modeling Problems. Srinivasan S., Biggers Jr. S.B., de Andrade J.R., Latour Jr. R.A., Clemson University, Department of Bioengineering, Clemson, USA. II-692. Biomechanical Evaluation of Bankart Reconstructions in a Human Cadaver Shoulder Model. Walsh W.R., Mohammed K., Howard M., Goldberg J., Sonnabend D.H., University of New South Wales, Prince of Wales Hospital, Traumatic and Orthopaedic Surgery, Randwick, Australia. BIORESORBABLES II-693. Biodegradable In-Situ Polymerizable Macromonomers I: Effect of Hydroxyacids on Micellization. Barman S.P., Coury A.J., Pathak C.P., Focal Inc., Lexington, USA. II-694. A Procedure to Prepare a Partially Absorbed Lactide Polymer for Image Analysis. Burg K.J.L., Powers D.L., Shalaby S.W., Clemson University, Department of Bioengineering, Clemson, USA. II-695. A New Torsion Test for Absorbable Screws. Champion A.R., DiMaio W.G., Reid J.J., DePuy DuPont Orthopaedics, Newark, USA. II-696. Biomechanical Characteristics of Block- Polymerized and Injection-Moulded Polylactide Rods. David A., Muller D., Pommer A., Muhr G., Bergmannsheil University Bochum, Department of Surgery, Bochum, Germany. II-697. Synthesis and Characterization of Biodegradable Block Copolymers of e-Caprolactone and D,L-Lactide by Potassium Poly(Ethylene Glycol)ate. Deng X., Zhu Z., Xiong C., Zhang L., Chengdu Institute of Organic Chemical Academia Sinica, Chengdu, China. II-698. Biodegradable Ligament Augmentation Device Produced with Braided Multifilaments of PLLA Fibers. Fambri L., Migliaresi C., De Lollis A., Mazzurana M., University of Trento, Department of Materials Engineering, Trento, Italy. II-699. Enhancement of the Mechanical Properties of Polylactides by Solid-State Extrusion: Poly(L- Lactide) Poly(L/D-Lactide) and Poly(L/DL- Lactide). Ferguson S, Wahl D., Gogolewski S., Polymer Research, AO/ASIF Research Institute, Davos, Switzerland. II-700. Sterility, Molecular and Mechanical Properties of Heat-Treated Resorbable Poly(ester-Amides) PEA 10. 2 and PEA 6.2. Gogolewski S., Michel P., Barrows T.H., Polymer Research, AO/ASIF Research Institute, Davos, Switzerland. II-701. Bioresorbable Implants for the Fixation of Unloaded Fractures in Cranial-Maxillofacial and Plastic Surgery. Hutmacher D., Hurzeler M.B., Kirsch A., Albert-Ludwigs University, Department of Biomechanics and Biomaterials, Freiburg, Germany. II-702. Effect of Thermal Treatment on Bioresorbable Polymers. Poddevin N., Laroche G., Guidoin R., Bioland, Toulouse, France. BLOOD-MATERIAL INTERACTIONS II-703. Improved Blood Compatibility of Segmented Polyurethane by Phospholipid Polymeric Additive. Nakabayashi N., Tanaka S., Iwasaki Y., Ishihara K., Tokyo Medical and Dental University, Institute for Medical and Dental Engineering, Chiyoda-ku, Japan. II-704. Improving Blood Compatibility of Biomaterials by Ion Beam Enhanced Deposition. Nan H., Ping Y., Xiaolan Z., Yuanru C., Xianghuai L., Sichang Z., Bingyao J., Southwest Jiatong University , Department of Materials Engineering, Chengdu, China. II-705. Methodological Approaches to Determine Protein Adsorption on Biomaterial Surfaces. Otto M., Klein C.L., Herold A., Koehler H., van Kooten T.G., Kirkpatrick C.J., Johannes Gutenberg-University, Institute of Pathology, Division of Experimental Pathology, Mainz, Germany. II-706. Platelet Cytoplasmic Calcium Levels in Contact with Modified Polyurethane Surfaces. Park K.D., Lee J.E., Lee W.K., Kim Y.H., Suzuki K., Sakurai Y., Okano T., Korean Institute of Science and Technology, Polymer Chemistry Laboratory, Seoul, Korea. II-707. Influence of Characterized Turbulent Flow on Platelet Behavior in Whole Blood. Rhodes N., Rattray A., Black R.A., Williams D.F., University of Liverpool, Clinical Engineering, Faculty of Medicine, Liverpool, UK. II-708. Studies on Complement Activation by Immunoglobulin G Immobilized on Hydrophobic Silicon. Tengvall P., Askendal A., Lundstrom I., Linkoping University, Laboratory of Applied Physics, Linkoping, Sweden. II-709. Thrombin and Factor XIIa Generation in Plasma Contacting Polyurethane Surfaces: Effect of Surface Immobilized PPACK. Tian Y., Weitz J.I., Brash J.L., Clemson University, Department of Bioengineering, Clemson, USA. II-710. Blood Protein Interactions with Chromium Surfaces. Walivaara B., Lundstrom I., Krozer A., Tengvall P., Linkoping University, Department of Physics and Measurement, Laboratory of Applied Physics, Linkoping, Sweden. II-711. Responses in Human Blood Following Contact with the Carmeda Immobilized Heparin Surface. Wolf M.F., Overend M.E., Fogt E.J., Rao G.H.R., Medtronic Inc., Minneapolis, USA. II-712. Interaction Between Phospholipids and Plasma Proteins. Yandao G., Nanming Z., Xuemei Z., Yong H., Xiufang Z., Tsinghua University, State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing, China. II-713. Platelet Adhesion on Adsorbed Sulfonated Block Copolymers. Zhang Y.Y., Kohler A.S., Tirrell M., University of Minnesota, Department of Chemical Engineering, Minneapolis, USA. BONE-MATERIAL INTERACTIONS II-714. Osteoblast Response to Surface Modified Polymer Electrets. Okun L., Valentini R.F., Brown University, Artificial Organs, Biomaterials and Cellular Technology Program, Providence, USA. II-715. Influence of Coral Architecture on Osteogenic Potential of Bone Marrow Cell-Coral Hybrid. Petite H., Louisia S., Kania R., Meunier A., Sedel L., UniversitŽ D. Diderot, Laboratoire de Recherches OrthopŽdiques, Paris, France. II-716. Human Osteoblast-Like Cells (MG63) Proliferation on Bioglass Surface. Price N. , Bendall S.P., Frondoza C., Jinnah R.H., Hungerford D.S., John Hopkins University, Department of Orthopaedic Surgery, Baltimore, USA. II-717. Effects of Charged Electrodes on the Adhesion of Primary Bone Marrow Stromal Cells. Qiu Q., Sayer M., Wan J., Kawaja M.D., Shen X., Davies J.E., Queen's University, Department of Physics, Kingston, Canada. II-718. Calcium Phosphate Thin Films to Assay the Effects of Calcium-Regulating Hormones on the Resorptive Function of Osteoclasts. Shen X., Gu X., Ni W., Rosenberg S., Davies J.E., University of Toronto, Centre for Biomaterials, Toronto, Canada. II-719. Experimental and Clinical Results of Hydroxyapatite Bioceramics Tissue Integration. Skagers A., Berzina L., Cimdins R., Salms G., Riga Technical University, Riga, Latvia. II-720. Bone-Bonding Properties of Surface-Modified Titanium Implants. Stachowski M.J., Baier R.E., Meyer A.E., Grobe G.L., Carter L., Thomson-Gordon Group, Burlington, Canada. II-721. Tetracycline Fluorescence: A New Method to Quantitate Bone Produced In-Vitro. Todescan R., Lowenberg B.F., Hosseini M.M., Davies J.E., University of Toronto, Centre for Biomaterials, Toronto, Canada. II-722. Metal Ions Interfere with Functions of Osteoblasts. Wang J.Y., Tsukayama D.T., Wicklund B.H., Gustilo R.B., Hennepin County Medical Center, Minneapolis, USA. II-723. Electrokinetic Reversibility of Phosphate Ion Effects. Weinstein C.L.J., Walsh W.R., Kotha S.P., Guzelsu N., UMDNJ, Biomechanics Department, Piscataway, USA. II-724. Scanning Electron Microscope Study of the Apposition of Bone to Implants. Yamada K., Iwata H., Imamura K., Maruno S., Nagoya University, Department of Orthopedic Surgery, Nagoya, Japan. II-725. Osteogenic Responses to Extraskeletally Implanted Porous Calcium Phosphate Ceramics: Diffences in Animal Species. Yang Z., Zou P., Chen W., Tong W., Yuan H., Zhang X., Sichuan Union University, Engineering Research Center in Biomaterials, Chengdu, China. CARDIOVASCULAR DEVICES II-726. Investigations on the Hemo- and Biocompatibility of Vascular Prostheses (Dacron/Gortex). Heller W., Wendel H.P., University of Tubingen, Department of Cardiovascular Surgery, Tubingen, Germany. II-727. Lipid Uptake in Synthetic Arterial Protheses: How to Evaluate the Lipid Concentration Profile Across the Wall. Laroche G., Mantovani D., Guidoin R., Quebec Biomaterials Institute, Departments of Metallurgy and Surgery, Quebec, Canada. II-728. Morphology of Vascular Cells on Bioactive Polysaccharide Surfaces: Prospects for Small Diameter Vascular Graft Development. Matthew H.W.T., Chupa J.M., Wayne State University, Chemical Engineering and Materials Science, Detroit, USA. II-729. Thromboresistance Screening Tests for Evaluating Long Term Central Venous Catheter Materials. Puryear H., Peckham S.M., Slack S.M., SIMS Deltec Inc., St. Paul, USA. II-730. The Bovine Pericardial Sac: Optimal Material Selection Sites. Sacks M.S., Hiester E.D., University of Miami, Department of Biomedical Engineering, Coral Gables, USA. II-731. Degradation Products of Poly(Ester-Ether- Ester) Block Copolymers Modulate In-Vitro Endothelin Release by Endothelial Cells. Sbarbati Del Guerra R., Del Chicca M.G., Cristallini C., Guerra G.D., Maltinti S., Tricoli M., Cerrai P., C.N.R. Institute of Clinical Physiology, Pisa, Italy. II-732. Endothelial Cell Activation on Biomaterials: Expression of the Inflammatory Marker E-Selectin. Schmierer A.E., Pohlman T.H., Ratner B.D., University of Washington, Department of Bioengineering, Seattle, USA. II-733. Controlled Release of Heparin from Polymers: Effect on Calcification of Porcine Aortic Cusps. Vyavahare N., Fuller A., Levy R.J. , University of Michigan, Medical Center, Ann Arbor, USA. II-734. Recombinant Hirudin Significantly Reduces Cellular Damage and Contact System Activation in an Ex-Vivo Cardiopulmonary Bypass Model. Wendell H., Heller W., Zierner G., University of Tubingen, Department of Cardiovascular Surgery, Tubingen, Germany. II-735. Effect of Vascular Stent Geometry on Porcine Aorta Damage: An In-Vitro Model. Woodell J., Rogers J.M., Childs D., Langan E.M., Taylor S., LaBerge M., Clemson University, Department of Bioengineering, Clemson, USA. II-736. A New Small Diameter Polyurethane Vascular Prosthesis: Microporous Structure and Animal Implantation. Zhang Z., Kodama M., Liu S., Wang Z., University Laval, Laboratory of Experimental Surgery, Sainte-Foy, Canada. CELL BIOLOGY II-737. Surface Characterization of Polystyrene Cell Culture Substrates. Belu A.M., Leach-Scampavia D., Ratner B.D., University of Washington, Department of Chemical Engineering, Seattle, USA. II-738. Regulation of Hepatocytes by Highly Oriented Extracellular Matrices: Atomic Force Microscopy Observation of Oriented ECM. Cho C.S., Takei R., Kobayashi A., Damrongchai N., Nomoto M., Akaike T., Chonnam National University, Department of Polymer Engineering, Kwangju, Korea. II-739. Equivalent Bone Healing Response in the Baboon to Grafton ABM Formulated from Low or Normal Bone Mineral Human Donors. Fox W.C., Aufdemorte T.B., Scarborough N., Manrique A.J., Poser J., Biomedical Enterprises, San Antonio, USA. II-740. Microcarrier Spinner Culture Enhances Proteoglycan Production by Human Chondrocytes. Frondoza C., Jeng C., Sohrabi A., Nakashima K., Hungerford D.S., Johns Hopkins University, Department of Orthopaedic Surgery, Baltimore, USA. II-741. The Effect of Titanium Surface Roughness on Cell Morphology. Gomi K., Saitoh S., Kanazashi M., Arai T., Nakamura J., Tsurumi University, Department of Periodontics, Yokohama, Japan. II-742. Induction of Nitric Oxide and TNF-a by LPS in Combination with PMMA HA and TIO2 Particles in Raw 2 64.7 Murine Macrophages. Hitchins V., Chamberlain V.C., Chapekar M.S., Zaremba T.G., Merritt K., Food and Drug Administration, Center for Devices and Radiol. Health, Rockville, USA. II-743. Effect of Na Ions on Extracellular Proteins Around Ionomeric Bone. Johal K.K., Carter D.H., Sloan P., Brook I.M., University of Sheffield, Department of Oral and Maxillofacial Surgery, Sheffield, UK. II-744. Quantification of Cell Morphology from Two Different Populations Colonising Different Polystyrene Surfaces In-Vitro Using Image Analysis. Landini G., Shelton R.M., University of Birmingham, School of Dentistry, Biomaterials Unit, Birmingham, UK. II-745. Cellular Behaviors on Well-Defined Gradient Surfaces. Matsuda T., Ueda-Yukosi T., National Cardiovascular Center, Research Institute, Department of Bioengineering, Osaka, Japan. II-746. Glucose Carrying Polymer Selectively Recognizes the Cell Mediated by a Glucose Transporter. Park K.H., Maruyama A., Goto M., Kobayashi A., Kobayashi K., Akaike T., Tokyo Institute of Technology, Department of Biomolecular Engineering, Faculty of Bioscience and Technology, Yokohama-shi, Japan. II-747. Determination of a DNA-like Active Site on Randomly Phosphorylated Polystyrene Derivatives. Pfluger F., Migonney V., Ravion O., Imbert E., Souirti A., Jozefowicz M., Universite Paris Nord, Institute Galilee, Villetaneuse, France. II-748. Changes in Membrane Electrical Properties Induced by Polylysine. Santini M.T., Cametti C., Indovina P.L., Morelli G., Donelli G., Istituto Superiore di Sanita, Laboratorio di Ultrastrutture, Roma, Italy. II-749. Behaviour of Rat Chondrocytes Cultured Upon a Glass-Ceramic. Sautier J.M., Forest N., Loty C., Kokubo T., University Paris VII, Lab Biologie-Odontologie, Inst. Biomedical Cordeliers, Paris, France. II-750. Human Monocyte Response to Titanium and Polymethylmethacrylate. Sawyer J.R., Gonzales J.B., Chan P.S., Horowitz S.M., University of Pennsylvania, Department of Orthopaedic Surgery, Philadelphia, USA. II-751. In-Vitro Responses of Osteoblast-Like Cells to Mechanical Stress by Stretching and Poking. Ushida T., Tateishi T., National Inst. for Adv. Interdisc. Res, Bionic Design Group, Ibaraki, Japan. II-752. Myoblast Seeding in a Collagen Matrix. van Wachem P.B., Brouwer L., van Luyn M.J.A., University of Groningen , Laboratory for Cell Biology and Electron Microscopy, Groningen, Netherlands. DENTAL MATERIALS II-753. Antibacterial Activity of Glass-Ionomer Cements. Hatton P., Marathakis A., Benderli Y., Douglas C.W.I., University of Sheffield, School of Clinical Dentistry, Biomaterials Research Group, Sheffield, UK. II-754. Experimental Fillers for Dental Composite Systems. Jones D.W., Rizkalla A.S., Dickinson R., Hall G.C., Dalhousie University, Department Applied Oral Sciences, Faculties of Dentistry and Medicine, Halifax, Canada. II-755. Fracture Mechanics of Biomaterials and Adhesive Interfaces. Ruse N.D., Troczynski T., MacEntee M., Feduik D., University of British Columbia, Oral Biology, Vancouver, Canada. II-756. Water Absorption and Viscoelasticity of Soft Polymers. Saber-Sheikh K., Clarke R.L., LHMC, Department of Biomaterials in Relation to Dentistry, London, UK. II-757. Effects of Dental Amalgam on the Cytokine Production in Human Peripheral Blood Mononuclear Cells In-Vitro. Schedle A., Rausch-Fan X.H., Samorapoompichit P., Franz A., Slavicek R., Valent P., Boltz-Nitulescu G., University of Vienna, School of Dentistry, Vienna, Austria. II-758. Marginal Fracture Toughness of Posterior Composite Resins. Tani Y., Amaratunga I., Togaya T., Ishikawa A., Kyoto University, Research Center for Biomedical Engineering, Kyoto, Japan. II-759. Durability and Aging in Dental Fissure Sealants. Vaubert V., Love B.J., Veit H.J., Kyle L., Viginia Polytechnic Institute and State University, Department of Materials Science, Blacksburg, USA. II-760. Alabama Bridge System: Design Optimization Based on Corrosion Characterization. Venugopalan R., Lucas L.C., Mueninghoff L., University of Alabama, Department of Biomedical Engineering, Birmingham, USA. II-761. Castability Studies of Novel Dental Glass- Ceramics. Walsh J.M., Johnson A., Hatton P.V., University of Sheffield, Department of Restorative Dentistry, School of Clinical Dentistry, Sheffield, UK. II-762. Retention and Release of Ions from Glass Ionomer Matrix. Williams J.A., Billington R.W., Pearson G.J., Eastman Dental Institute, Biomaterials Department, London, UK. II-763. Bond Strength of a Newly Developed Multipurpose Resin Bonding System. Yamada T., Inokoshi S., Kanemura N., Urabe I., Nakajima M., Tagami J., Tokyo Medical and Dental University, Tokyo, Japan. II-764. Bending Properties of Co-Ni-Cr-Mo Alloy Wire for Orthodontic Use. Yoneyama T., Doi H., Kobayashi E., Hamanaka H., Bonfield W., Tokyo Medical and Dental University, Institute for Medical and Dental Engineering, Tokyo, Japan. DRUG DELIVERY II-765. Synthesis and Characterization of New Polymeric Systems Bearing Vitamin E. San Roman J., Ortiz C., Plasencia M.A., Lopez Alonso J., Instituto de C. y T. de Polimeros, Madrid, Spain. II-766. Local Heparin Delivery Intravascular Stents from a Copolymer of e-Caprolactone and D,L-Lactide. Shi R., Gao R., Miao L., Wu D., Song C., Wang P., Institute of Biomedical Engineering, CAMS, Tianjin, China. II-767. N-Isopropylacrylamide-Based Copolymer for Encapsulation of Pancreatic Islets. Shimizu S., Kubato S., Moriya H., Watanabe T., Hasegawa K., Nagaya M., Yamaguchi S., St. Marianna University, First Department of Surgery, Kanagawa, Japan. II-768. Synthesis Characterization and Degradation Behaviour of Degradable Biomedical Polymers. Stridsberg K., Lofgren A., Schulze M., Albertsson A.C., Royal Institute of Technology , Department of Polymer Technology, Stockholm, Sweden. II-769. A Novel Compound Drug Enhancing Fibrin Formation. Sugitachi A., Shindoh T., Yamamoto K., Iwate Pref. Ohfunato Institute, for Health, Ohfubato, Japan. II-770. Selective Release of R(-) and S(+) Stereo- isomers of Ibuprofen from Composites of AI2O3/PLLA/PMMA for Orthopaedic Surgery. Vallet-Regi M., Dpto. Quimica Inorganica Y Bioin, Facultad Farmacia, Madrid, Spain. II-771. Early Factor Release for Improving Morphology of Detachable Retinal Pigment Epithelium Culture. von Recum H., Okano T., Kolb H., Kim S.W., University of Utah, Department of Bioengineering, Salt Lake City, USA. II-772. Gel Swelling of Two Different PVA-MA Films. Wang Y.J., Liou F.J., National Yang Ming University, Institute of Biomedical Engineering, Taipei, Taiwan. II-773. Effect of Buffer Type on pH-Sensitive Controlled Release. Wei L., Yan J., Batich C.D., Shen C., University of Florida, Department of Pathology, Department of Materials Science and Engineering, Gainesville, USA. II-774. Control of Protein Release from Emulsion Freeze-Dried Scaffolds with Unique Microarchitecture. Whang K., Goldstick T.K., Healy K.E., Northwestern Universtiy, Division of Biological Material, Chicago, USA. II-775. Thermally-Regulated Drug Delivery System - Paradox and Prediction. Wu X., Lee P., University of Toronto, Faculty of Pharmacy, Toronto, Canada. II-776. Poly(Lactic-Co-Glycolic Acid)-Phospholipid Composite for Protein Drug Delivery. Wu X.S., Madiba M., Long Island University, Division of Pharmaceutics, Brooklyn, USA. II-777. Design of Polymeric Micelles for Antitumor Drugs. Yokoyama M., Okano T., Sakurai Y., Kataoka K., Tokyo Women's Medical College, Institute of Biomedical Engineering, Tokyo, Japan. II-778. Double-Stimuli Responsive Degradable Hydrogels: Interpenetrating Polymer Networks of Gelatin and Dextran. Yui N., Kurisawa M., Yamamoto N., Japan Advanced Institute of Science and Technology, Ishikawa, Japan. JOINT TRIBOLOGY II-779. Surface Treatments to Improve Tribological Behaviour in Hip Joint Prostheses. Brossa F., Fare S., Paracchini L., Cigada A., Severgnini C., Mattavelli D., Joint Research Centre, Institute for Advanced Materials, Ispra, Italy. II-781. A Friction Study of Cobalt-Based Alloys for Metal-Metal Hip Implants. Cipera W.M., Medley J.B., University of Waterloo, Department of Mechanical Engineering, Waterloo, Canada. II-782. Conformity and Contact Pressures in Total Shoulder Arthroplasty. Friedman R.J., An Y.H., Draughn R.A., Medical University of South Carolina, Department of Orthopaedic Surgery, Charleston, USA. II-783. Polyethylene Wear on the Distal Tibial Insert Surface in Total Knee Arthroplasty. Gabriel S.M., Dennis D.A., Honey M.J., Scott R.D., Johnson & Johnson Orthopaedics, Raynham, USA. II-784. Investigation Into the Biphasic Properties of a Hydrogel for Use as a Cushion Form Bearing in a Replacement Joint. Goldsmith A., Clift S.E., University of Bath, School of Mechanical Engineering, Bath, UK. II-785. A Tribological Evaluation of Amorphous Diamond Like Carbon Coating for Use in Total Joint Replacement. Hailey J., Firkins P., Butter R., Lettington A., Fisher J., University of Leeds, Department of Mechanical Engineering, Leeds, UK. II-786. Comparison Between Cirulen Hylamer and Enduron: Tribological Aspects. Huber J., Plitz W., Walter A., Refior H., Labor. fŸr Biomechanik, Klinikum Grosshadern, Munchen, Germany. II-787. Lubrication Mechanisms in Metal-On-Metal Hip Joint Replacements. Jin Z.M., Dowson D., Fisher J., University of Bradford, Department of Mechanical and Manufacturing Engineering, Bradford, UK. II-788. Development of a New Pin On Disk Testing Machine for Evaluating Polyethylene Wear. O'Connor D.O., Bragdon C.R., Lowenstein J.D., Jasty M., Harris W.H., Massachusetts General Hospital, Orthopaedics Biomechanical Laboratory, Boston, USA. II-789. Tribological Behaviour of Co-Cr-Mo Alloy Modified by Ion Implantation. Paracchini L., Cigada A., Fare S., Brossa F., Ulivi M., Brignola J.C., Joint Research Centre, Institute for Advanced Materials, Ispra, Italy. II-790. Composite Cushion Form Knee Joint Replacements. Stewart T.D., Fisher J., University of Leeds, Department of Mechanical Engineering, Leeds, UK. II-791. The Effect of Decreasing Inclination of Acetabular Cups on Stresses. Zhu M.K., Christie J.M., DeBoer D.K., Spengler D.M., Vanderbilt University, Department of Orthopaedics and Rehabilitation, Austin, USA. ORTHOP(r)DICS II-792. Degradation Characteristics of a Biodegradable Fracture Fixation Plate. Agrawal C.M., Fan M., Shen X., Alder M., University of Texas, Health Science Center, San Antonio, USA. II-794. Press-Fit Placement of Implants in Cortical Bone: Decrease of Implant Integration as a Result of Remodelling. Dhert W.J.A., Thomsen P., Blomgren A.K., Ericson L.E., Verbout A.J., Utrecht University Cluster of Orthopaedics, Netherlands. II-795. The Design, Development and Testing of a Novel Femoral Component Using Advanced Composite Technology. Evans S.L., Gregson P.J., Doherty P.D., Williams D.F., Osei D., Revell P.A., Taylor A., University of Southampton, Engineering Materials, Southampton, UK. II-796. Formalin Contamination of Cobalt and Aluminum Tissue Samples. Meldrum R.D., S.F. Orthopedic Residency Program, San Francisco, USA. II-797. In-Vivo Study of Anodized Commercially Pure Titanium and Diffusion Hardened Ti-13Nb-13Zr Bone Plates in a Goat Model. Mishra A., Bucknell A.L., Vaughn C.M., FitzGerald T.J., Castleman D.W., Horton M., James A.H., Smith and Nephew Richards, Memphis, USA. II-798. A Physical, Chemical and Mechanical Evaluation of a Retrieved Zyranox Zirconia Femoral Head 1 1/2 Years After Implantation. Murray M., Pryce A., Morgan Matroc limited, Rugby Division , Bioceramic Products, Warwickshire, UK. II-799. An Investigation into the Frequency and Mechanism of Air Void Accumulation About a Common Design of Distal Centralizer. Noble P.C., Collier M.B., Kamaric E., Baylor College of Medicine, Houston, USA. II-800. Adhesive Strength of Periosteal Grafts to Articular Cartilage Using Fibrin. Orr T.E., Patel A.M., Hatzigiannis G.P., Minas T., Spector M., VA Medical Center, Rehabilitation Engineering Research and Development, Roxbury, USA. II-801. Improved Tensile Strength of Bone Cement by Ultrasonic Vibration. Saha S., Kumar A., Loma Linda University, Department of Restorative Dentistry, School of Dentistry, Loma Linda, USA. II-802. Osteoinductivity of a New Form of Demineralized Bone as Demonstrated in the Athymic Rat. Scarborough N.L., Dowd M., Manrique A., Fox W.C., Swain L.D., Aufdemorte T.B., Osteotech Inc., Shrewsbury, USA. II-803. Fiber/Matrix Interface Studies on Totally and Partially Absorbable Composite Materials for Internal Fixation of Bone Fractures. Slivka M.A., Chu C.C., Adisaputro I., Cornell University, Department of Textile and Apparel, Fiber Science Program, Ithica, USA. II-804. Vascularized Periosteum Associated with Either Bone Autograft or Coral Implant: A Histomorphometrical Study in Sheep. Therin M., Payement G., Dansard C., Biomatech Medical Devices Testing Laboratory, Chasse, France. II-805. A Comparative Histologic and Histomorphometric Study of Hydroxyapatite(HA) Versus Non HA-Coated Cementless Knee Implants: An Experimental Study in Sheep. Van Campenhout H., Labey L., Van Brussel K., Vander Sloten J., Van Auderkercke R., Van der Perre G., Bellemans J., Celestijnenlaan, Heverlee, Belgium. POLYETHYLENE II-806. Surface Oxidation Index and Its Depth Profile of Ultra-High Molecular Weight Polyethylene Upon g-Irradiation Sterilization. Gsell R.A., Lee K.H., Chu C.C., Lin S., Cornell University, Department of Textile and Apparel, Fiber Science Program, Ithaca, USA. II-807. The Role of Packaging In Sterilization of UHMWPE. Hamilton J.V., Flynn T., Johnson & Johnson Professional Inc, Raynham, USA. II-808. Oxidative Degradation and Embrittlement of Ultrahigh Molecular Weight Polyethylene: Analysis of 107 Components. Muratoglu O., Liu A., Jasty M., Bragdon C.R., Elder J.R., Harris W.H., Massachusetts General Hospital, Orthopaedics Biomechanical, Laboratory, Boston, USA. II-809. Preliminary Results on the Degradation Rate of Hydrogen Peroxide in Aqueous Solutions. Pascaud R.S., Evans W.T., McCullagh P.J.J., FitzPatrick D., University of Glamorgan, Department of Mechanical Engineering, Mid Glamorgan, UK. II-810. Dynamic Mechanical Analysis of Gamma Sterilized Aged UHMWPE. Ruger L.M., Love B.J., Drews M.J., Hutton W.C., LaBerge M., Clemson University, Department of Bioengineering, Clemson, USA. POLYMERS II-811. The Role of Free Radicals In Hydrolytic Degradation of Absorbable Polymeric Biomaterials. Lee K.H., Chu C.C., Cornell University, Department of Textile and Apparel, Fiber Science Program, Ithaca, USA. II-812. Temperature-Response Polymers and High Performance Size-Exclusion Chromatography Using Poly(N-isopropylacrylamide) Grafted Silica. Muller D., Lakhiari H., Okano T., Jozefonvicz J., UniversitŽ Paris Nord, LRM CNRS-URA, Villetaneuse, France. II-813. Solution Turbidity Improvement in Medical Packaging. Shang S.W., Buan-delos Santos L., Stewart-Wesson M., Baxter Healthcare Corporation, Round Lake, USA. II-814. In-Vitro and In-Vivo Stability Study of a Polyurethane Used in Enteral Nutrition. Tanzi M.C., Moscatelli M., Gavassa L., Palmo A., Protta F., Politechnic of Milan, Bioengineering Department, Milano, Italy. II-815. Strength Change of High-Strength Poly(vinyl Alcohol) Fiber In-Vivo. Tomita N., Nagata N., Ikada Y., Kyoto University, Research Center for Biomedical Engineering, Kyoto, Japan. II-816. Gelation Mechanism and Resultant Structure of PVA Hydrogels. Trieu H.H., Qutubuddin S., Wright Medical Technology, Research and Development, Arlington, USA. II-817. Degradation Behaviour of Improved Polycaprolactone In-Vitro and In-Vivo. Wang S., Institute of Chemistry, Academia Sinica, Beijing, China. II-818. Surface Activity and Enhanced In-Vivo Biostability of a Segmented Polyetherurethane with Polydimethylsiloxane End Groups. Ward R.S., Coviello S., Gill R.S., White K.A., Bertolet R.D., Polymer Technology Group Inc., Emeryville, USA. II-819. Immunological Properties of Polyphosphate- Phosphoramide. Xu M.Y., Mao H.Q., Wang J., Zhuo R.X., Wahun University, Department of Chemistry, Wahun, China. II-820. Water Permeability of Polyurethane Membranes. Yang M.J., Deng X.Y., Guidoin R., Laval University, Department of Surgery, Sainte-Foy, Canada. SILICONES II-821. Surface Modification of Silicone Rubber by Methanol Plasma. Chen X., Wang J.Q., Biomedical Polymer Laboratory, Insitute of Rehabilitation Medicine, China Rehabilitation Reseach Center, Beijing, China. II-822. Pressure Sensitive Organo-Silicon Adhesive for Biomedical Applications. Hu Y., Xu L. , Ding X., Pan H., Liang Q., Huang Y., Li A., South China University of Technology, Research Institute of Materials Science, Guangzhou, China. II-823. Biocompatibility Evaluations of Medical Grade Silicone Elastomer. Lockhorn N., Lacy S., Lucas L.C., Univeristy of Alabama, Department of Biomedical Engineering, Birmingham, USA. II-824. The Modelling of Water Uptake of Elastomers. Riggs P., Parker S., Braden M., Kalachandra S., LHMC, Department of Biomaterials in Relation to Dentistry, London, UK. II-825. In-Vivo MR Detection of Silicone Gel Degradation. Stroman P., Alikacem N., Mayanloo M., Dorvil J.C., Guidoin R., Quebec Biomaterials Institute, Departments of Metallurgy and Surgery, Quebec, Canada. II-826. Conformational Change and Denaturation of Proteins By Cyclic Silicone. Sun L., Alexander H., Lattarulo N., Blumenthal N.C., Ricci J.L., Chen G., Hospital for Joint Diseases, Department of Bioengineering, New York, USA. SURFACE MODIFICATION II-827. Poly(ethylene Oxide) Coated Surfaces via a New Process. Merrill E.W., Allgor S.J.S., Leung G., Massachusetts Institute of Technology, Department of Chemical Engineering, Cambridge, USA. II-828. Synthesis, Characterization and Properties of Heparin Surfactants. Mintz R.C., Cai W., Marchant R.E., Case Western Reserve University, Department of Biomedical Engineering and Macromolecular Science, Cleveland, USA. II-829. Surface Modification of Polytetrafluoro- ethylene by Ultraviolet Irradiation for Blood Contacting Biomaterials. Noh I., Hubbell J.A., California Institute of Technology, Division of Chemistry and Chemical Engineering, Pasadena, USA. II-830. PET Amination by Ammonia Plasma Treatment: Peptide Grafting and Cell Adhesion Tests. Pireaux J.J., Girardeaux C., Caudano R., Facultes Universitaires Notre- Dame de la Paix, Laboratoire LISE, Namur, Belgium. II-831. Influence of Sodium Hydroxide Anodization of Titanium Adherends Bonded to Poly Ether Ketone Ether Ketone Ketone. Ramani K., Ingram C., Devanathan D., Purdue University, School of Mechanical Engineering, West Lafayette, USA. II-832. X-Ray Diffraction Studies of Vacuum Plasma- Sprayed Hydroxyapatite Coatings After Immersion in Simulated Body Fluid and Fetal Calf Serum. Reber R., Ha S.W., Baerlocher C., Wintermantel E., Gruner H., ETH Zurich, Schlieren, Switzerland. II-833. Geometrically Structured Acrylic Resin and Titanium Implants in Hard Tissue. Schmitz H.J., Krantz C., Graff S., Aachen University, Department of Oral/Maxillofacial and Facial Surgery, Aachen, Germany. II-834. Surface-Dependent Structure Morphology- Relations in Coated and Non-Coated Titanium Implants. Schmitz H.J., Bantel M., Graff S., Aachen University, Department of Oral/Maxillofacial and Facial Surgery, Aachen, Germany. II-835. Surface Modification of Prosthetic Arterial Grafts. Seeger J.M., Albright J.L., Klingman N.V., Amery D., Widenhouse C., Martin P., Goldberg E.P., University of Florida, College of Medicine, Gainesville, USA. II-836. Foundation of Intended Molecular Structure on Surface of Biomaterials. Si-Chong L., An-Feng W., Jing-Lu C., Cai-Hua Z., Nanjing University, Department of Polymer Science and Engineering, Nanjing, China. II-837. Physico-Chemical Characterization of a Ti Textured Surface Prepared by Sandblasting and Acid Etching. Szmukler-Moncler S., Simpson J.P., Institut Straumann, Waldenburg- CH, Switzerland. II-838. Influence of Surface Treatments on the Physical and Biological Properties of Titanium. Taborelli M., Jobin M., Descouts P., Vaudaux P., Francois P., Tonetti M., University of Geneva, GAP-Biomedical, Geneva, Switzerland. II-839. Active Brazing: A Novel Approach for the Fabrication of Ceramic Prostheses in Orthopedic and Dental Surgery. Tillmann W., Lugscheider E., Sicking R., Aachen University of Technology, Materials Science Institute, Aachen, Germany. II-840. Peptide and Amino Acids Amphiphiles: Synthesis and Properties. Tirrell M., Berndt P., Fields G.B., Yu Y., Schneider J., Chiruvolu S., Kumar S., University of Minnesota, Department of Chemical Engineering and Materials Science, Minneapolis, USA. II-841. Measurement of Titanium Ions in Rat Abdominal Wall by Proton Induced X-Ray Emission (PIXE). Tsuboi Y., Ektessabi A.M., Sennerby L., Otsuka T., Albrektsson T., Iizuka T., Kyoto University, Faculty of Medicine, Department of Oral and Maxillofacial Surgery, Kyoto, Japan. TISSUE ENGINEERING II-842. The Development of Mechanical Properties in Organotypically Cultured Human Skin. Cavallaro J.F., Cosman M.D., Watson S.R. , Organogenesis Inc., Canton, USA. II-843. Synthesis of Macro-Spheres of Amino- Polymers: Immobilization of Biocompounds and Evaluation of Use In ELISA Test. Mei L.H.I., Baltieri R.C., Bittencourt E., Tamashiro W.M.S.C., Universidade de Campinas, Faculdade de Engenharia, Campinas, Brazil. II-844. Lectin-Mimicking Functional Polymer: Boronate-Containing Polymer as Synthetic Mitogen for Lymphocytes. Miyazaki H., Okano T., Sakurai Y., Kataoka K., University of Tokyo, Department of Material Science, Noda-shi, Japan. II-845. Surface Modification of Three-Dimensional Matrices for Tissue-Engineering. Morra M., Cassinelli C., Canonico P., Nobil Bio Ricerche, Villafranco D'Asti, Italy. II-846. Porous Hydroxyapatite with Intrinsic Osteoinductive Activity. Ripamonti U., Kirkbride A.N., University of the Witwatersrand, Medical School, Bone Research Laboratory, Johannesburg, South Africa. II-847. Bioerodible Polyester Foams for Orthopaedic Tissue Culture. Selmani A., Chaput C., Yahia L.H., Rivard C.H., Ecole Polytechnique, Department Chemical Engineering, Montreal, Canada. II-848. Analysis of Osteoblast Mineral Deposits on Three-Dimensional Porous Polylactic Acid Scaffolds. Supronowicz P., Ricci J.L., Bakhru H., Bizios R., Rensselaer Polytechnic Institute, Department of Biomedical Engineering, Troy, USA. II-849. Derivatized Hyaluronic Acid Films Support Mesenchymal Stem Cell Attachment and Proliferation. Valentini R.F., Tona A., Brown University, Artificial Organs, Biomaterials and Cellular Technology Program, Providence, USA. II-850. Cell-Polymer Biohybrid Technology for Neural Tissue Growth and Reconstruction. Woerly S., Gheammaghami G., Gazeilles S., Organolgel Canada Ltee, Sainte-Foy, Canada. II-851. Functional Activities of Hepatoma Cells on Biomaterial Supports. Yu Y.T., Shi Q., Nankai University, Molecular Biology Institute, Tianjin, China. II-852. FGF-1 and Heparin Retention Within Fibrin Glue Impregnated Into ePTFE Grafts and Perfused In-Vitro Under Pulsatile Conditions. Zarge J.I., Gosselin C., Greisler H.P., Loyola University, Medical Center, Maywood, USA. WEAR DEBRIS II-853. Numerical Particle Analysis of Individual UHMWPE Particles. Landry M., Jaroszeswki D.E., Szygenda D.M., Mabrey J.D., Blanchard C., Agrawal C.M., University of Texas, Health Science Center, San Antonio, USA. II-854. Twenty-Year Wear Analysis of Retrieved Metal-Metal Hip Prostheses. McKellop H., Park S.H., Chiesa R., Lu B., Normand P., Doorn P., Amstutz H., University of Southern California, Orthopaedic Hospital, Los Angeles, USA. II-855. Cell Culture Response of Synovial Fibroblasts to Prosthetic Metal Particles. Mostardi R.A., Meerbaum S.O., Kovacik M.W., Gradisar I.A., Summa Health Systems, Department of Orthopaedic Surgery, Arkon, USA. II-856. Effects of Particulate Debris on the Release of MM P-2 and MMP-9 from Human Macrophages In-Vitro. Nakashima Y., Maloney W.J., Goodman S.B., Sun D.H., Shurman D.J., Smith R.L., Stanford University Medical Center, Orthopaedic Research Laboratory, Stanford, USA. II-857. Characterization of UHMWPE Wear Debris in Synovial Fluids of Patients with Total Knee Replacements. Peterson C.J., Shriki J.H., Szivek J.A., Benjamin J.B., University of Arizona, Department of Surgery and Orthopaedics, Tuscon, USA. II-858. Effects of Phagocytosis of Polyethylene Particles on Macrophage Line IC-21 Cells. Shirata K., Ushida T., Tateishi T., National Institute for Adv. Interd. Res, Bionic Design Group, Ibaraki, Japan. II-859. In-Vivo Wear of an Enhanced Polyethylene. Thomas B.J., Moreland J.R., Preiss S., UCLA School of Medicine, Los Angeles, USA. II-860. Phagocytosis of Polyethylene Particulate by Macrophages In-Vitro. Voronov I., Hinek A., Callahan J.W., Santerre J.P., Boynton E.L., University of Toronto, Centre for Biomaterials, Toronto, Canada. II-861. Extraction and Characterization of Metallic Wear Particles in Total Joint Replacements. Yamac T., Kobayashi A., Bonfield W., Kadoya Y., Freeman M., Scott G., Revell P., Royal Free Hospital School of Medicine, Department of Histopathology, Osteoarticular Research Group, London, UK. II-862. Qualitative Analysis of the Wear Debris Recovered from a Hip-Joint Simulator. Yu L., Anissian L., Ching B., Frykman E., Loma Linda University, Department of Orthopaedic Surgery, Medical Center, Loma Linda, USA. ___________________________________________________________ Saturday, June 1: Oral Session 8 2:30-3:30 METALS II Room 206A/B Chairs: K. Merritt, J. Gilbert 2:30 I-863. Properties Of Ti and Ti6AL4V Surface Oxides as Determined by Nuclear Reaction Analysis and X-Ray Photoelectron Spectroscopy. Callen B.W., Sodhi R.N.S., Griffiths K., University of Toronto, Centre for Biomaterials, Toronto, Canada. 2:45 I-864. A Combined Step-Polarization-Laplace Transform Impedance Spectroscopy Analysis of Co-Cr-Mo in Physiological Solutions. Gilbert J.L., Shibayama J., Northwestern Universtiy, Division of Biological Material, Chicago, USA. 3:00: I-865. In-Vitro Fretting Corrosion Testing of Modular Hip Implants. Goldberg J.R., Jacobs J.J., Gilbert J.L., Northwestern Universtiy, Division of Biological Material, Chicago, USA. 3:15: I-866. In-Vitro Study on Low Nickel Stainless Steel. Sun X., Ito A., Okayama S., Tateishi T., Hoshino A., National Inst. for Adv. Interd. Res, Bionic Design Group, Ibaraki, Japan. BIOHYBRID ORGANS Room 206C/D Chairs: T. Akaike, S.W. Kim 2:30 I-867. Poly (Ethylene Glycol) Based Encapsulation of Islets of Langerhans. Cruise G.M., Lamberti F.V., Hegre O.D., Hubbell J.A., California Institute of Technology, Division of Chemistry and, Chemical Engineering, Pasedena, USA. 2:45 I-868. Non-Woven Biomaterials for Biohybrid Organs. Doser M., Dauner M., Thasler W., Pahernik S., Koebe H., Gomez-Lecon M., Castell J., Inst. of Textile and Process Eng., Department of Biomedical, Engineering, Denkendorf, Germany. 3:00: I-869. Viability and Function of Conformally Coated Mammalian Cells in Hema-MMA. May M.H., Sefton M.V., University of Toronto, Dept. of Chemical Engineering , & Applied Chemistry, Toronto, Canada. 3:15: I-870. Synthetic Extracellular Matrix for Islets of Langerhans in Development of Biohybrid Artificial Pancreas Using Thermally Reversible Polymer Gels. Vernon B., Kim S.W. , Bae Y.H., University of Utah, Salt Lake City, USA. JOINT TRIBOLOGY II Room206E/F Chairs: M. Laberge, H.A. McKellop 2:30 I-871. Stability of Serum as a Lubricant in Wear Simulator Tests of Prosthetic Joints. McKellop H.A., Liao Y.S., Benya P.D., Lu B., University of Southern California, Orthopaedic Hospital, Los Angeles, USA. 2:45 I-872. A Simple Method for Assessing the Third-Body Abrasive Wear Resistance of UHMWPE in a Hip Joint Wear Simulator. Polineni V.K., Wang A., Stark C., Dumbleton J.H., Howmedica Inc., Division of Pfizer Hospital, Products Group, Rutherford, USA. 3:00: I-873. Effect of Phosphatidylcholine Chain Length on the Friction of Rigid Bearing Surfaces. Rogers J.M., Powell G.L., Joseph P.F., Pace T.B., LaBerge M., Clemson University, Department of Bioengineering, Clemson, USA. 3:15: I-874. Distribution of Frictional Stresses at the Articular Surfaces of Human Hip Joint During Gait and Its Effect on Wear of UHMWPE Acetabular Cups. Wang A., Sokol M., Stark C., Dumbleton J.H., Howmedica Inc., Division of Pfizer Hospital , Products Group, Rutherford, USA. DRUG DELIVERY III Room104A/B Chairs: T. Okano, Y-L Cheng 2:30 I-875. Novel Glucose-Sensitive Phase Transition Gel of N-Isopropylacrylamide With 3-Acrylamidophenylboronic Acid Group as Command Moiety. Miyazaki H., Sasagawa G., Okano T., Sakurai Y., Kataoka K., University of Tokyo, Department of Material Science, Noda-shi, Japan. 2:45 I-876. Poly(Lactic Acid) Microspheres for Oral Vaccine. Tabata Y., Inoue Y., Ikada Y., Kyoto University, Research Center for Biomedical, Engineering, Kyoto, Japan. 3:00: I-877. The Effects of Cyclic Compressive Loading on a Biodegradable Implant. Thompson D., Agrawal C.M., Athanasiou K.A., University of Texas, Health Science Center, San Antonio, USA. 3:15: I-878. Heterogeneous Polyelectrolyte Gels as Variable Permeability Membranes. Turner J.S.A., Cheng Y.L., University of Toronto, Department of Chemical Engineering, and Applied Chemistry, Toronto, Canada. BLOOD-DEVICE INTERACTIONS Room 104C Chairs: R. Cornelius, C.P. Sharma 2:30 I-879. Surface Modification of Chitosan Hemodialysis Membranes with Anionic Polysaccharides. Amiji M.M., Northeastern University, Department of Pharmaceutical, Sciences, Boston, USA. 2:45 I-880. Bio-Inhibited Formation of Apatite. Martin R., Brown P.W., Penn State University, University Park, USA. 3:00: I-881. Development of Immunoadsorbent Matrix Based on Poly Vinyl Alcohol (PVA) for Direct Haemoperfusion. Sharma C.P., Hari P.R., Paul W., Panikkar B., Chandy T., Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India. 3:15: I-882. A Multidisciplinary Approach is Necessary to Study the Long Term Behaviour of Polyethylene Terephtalate Vascular Prostheses in Humans. Urban E., Chafke N., Cottin Bizonne S., Le Magnen J.F., Kretz J.G., Zollner G., Durand B., Laboratoire de Physique et Mecanique Textiles, Mulhouse, France. SURFACE STUDIES Room 104D Chairs: D.G. Castner, J.E. McGuire 2:30 I-883. Covalent Attachment of Albumin onto Aldehyde-RFGD Treated Fluoropolymers and Aluminium. Beumer E.J. , Chatelier R.C., St. John H.A.W., Griesser H.J., CSIRO, Division of Chemicals and Polymers, Clayton, Australia. 2:45 I-884. Elaboration Characterization and Interest of Modelized Surfaces with Well Defined Microtopochemistry. Durieu M.C., N'Kaoua G., Baquey C., Universite de Bordeaux II, INSERM-U 306, Bordeaux, France. 3:00: I-885. Crystallization and Hydroxyapatite Formation on the Surface of Bioactive Glass Coated Alumina. Kim C.Y., Lee E.S., Inha University, Department of Ceramic Engineering, Nam-ku, Korea. 3:15: I-886. Protein Adsorption to Surfaces of Self- Assembling Monolayers. Mao G., McGuire J., Grainger D.W., Colorado State University, Department of Chemistry, Fort Collins, USA. ___________________________________________________________ Saturday, June 1: Oral Session 9 4:00-5:30 BONE CELL CULTURE Room 206A/B Chairs: J.E. Davies, K.E. Healy 4:00: I-887. Mineralizing Human Bone Marrow Cell Culture System to Evaluate Bone Replacement Materials. de Bruijn J., vd Brink I., Leenders H.L., Bovell Y.P., University of Leiden, Biomaterials Research Group, Bilthoven, Netherlands. 4:15: I-888. Culture of Adult Human Jaw Bone Cells on Heterologous Bovine Cancellous Bone. De Santis D., Guerriero C., Nocini P.F., Armato U., University of Verona, Dental Department, Verona, Italy. 4:30: I-889. In-Vitro Bone Formation by Adult Bone Cells Among Small Granules of Porous Hydroxyapatite. Kawai N., Niwa S., Sato Y., Sato M., Ichihara I., Aichi Medical University, Department of Anatomy, Aichi, Japan. 4:45: I-890. In-Vitro Examination of Novel Calcium Phosphates Using Osteogenic Cultures. Knabe C., Gildenhaar R., Berger G., Ostapowicz W., Fitzner R., Radlanski R., Gross U., Free University of Berlin, University Hosp. Benjamin Franklin, Dept. of Prosthodontics II, Berlin, Germany. 5:00: I-891. Cell-Binding Peptides for Enhancing The Strength of Osteoblast Adhesion. Rezania A., Thomas C.H., Bearinger J., Healy K.E., Northwestern Universtiy, Division of Biological Material, Chicago, USA. 5:15: I-892. The Functional Expression of Human Bone Derived Cells Grown on Biomaterials: An In-Vitro Assay. Zreiqat H., Markovic B., Walsh W., Howlett C.R., University of New South Wales, School of Pathology, Bone Biomaterial Unit, Sydney, Australia. POLYMERS Room 206D/C Chairs: M. Shoichet, R. Marchand 4:00: I-893. Surface Phosphonylation of Polyethylene to Create a Calcium Ion-Binding Surface. Campbell C.E., Russell A.M., Hudson J.S., van Recum A.F., Shalaby S.W., Clemson University, Department of Bioengineering, Clemson, USA. 4:15: I-894. Bioartificial Materials by Template Polymerization. Cascone M.G., Polacco G., Lazzeri L., Petarca L., Maltinti G., Cristallini C., Barbani N., University of Pisa, Department of Chemical Engineering, Pisa, Italy. 4:30: I-895. Biocompatibility and Biodegradability of Novel Block Copolymers. Ciardelli G., Saad B., Hirt T.D., Keiser O., Neuenschwander P., Suter U.W., Swiss Federal Inst. of Technology, Institute of Polymers, Zurich, Switzerland. 4:45: I-896. Hydrophilic Sponges Based on 2- Hydroxyethyl Methacrylate. Clayton A., Chirila T., Dalton P., Lou X., Lions Eye Institute, Nedlands, Australia. 5:00: I-897. Site-Specific Conjugation of a Temperature-Sensitive Polymer to a Genetically-Engineered Protein. Hoffman A.S., Shimoboji T., Stayton P.S., Long C., Chilkoti A., Chen G., Harris J.M., University of Washington, Center for Bioengineering, Seattle, USA. 5:15: I-898. Novel Polymeric Materials Featuring Biocompatibility and X-Ray Visibility. Kruft M.A.B., Benzina A., Koole L.H., BIOPRIME, Maastricht, Netherlands. WEAR PARTICULATES I Room 206E/F Chairs: M. Spector, D.F. Gibbons 4:00: I-899. Effect of Polyethelene Wear Debris on Synoviocytes. Frondoza C., Sohrabi A., Bendall S., Kohilas K., Hungerford D.S., Jinnah R.H., John Hopkins University, Department of Orthopaedic Surgery, Baltimore, USA. 4:15: I-900. Human Macrophage and Lymphocyte Response to Polymethylmethacrylate Particles In-Vitro. Gonzalez O., Smith R.L., Goodman S.B., Stanford School of Medicine, Orthopaedic Research Lab., Stanford, USA. 4:30: I-901. Relation Inducible Stress Proteins and Cell Death to Chemistry and Total Surface Area of Particles. Gysbers J.E., Gibbons D.F., Kato K.H., 3M Center, Life Sciences Sector Laboratory, St. Paul, USA. 4:45: I-902. The Effect of Particulate PMMA in a Canine Model of Loosened Orthopaedic Implants. Jones L.C., Frondoza C., Hungerford D.S., John Hopkins University, Department of Orthopaedic Surgery, Baltimore, USA. 5:00: I-903. Effects of Polyethylene Particles on Rabbit Knee Joints. Mukherjee D.P., Rogers S.H., Sadasivan K.K., Schmidt D.G., Meyer M.A., Albright J.A., Louisiana State University, Medical Center, Department of Orthopedic Surgery, Shreveport, USA. 5:15: I-904. Effects of Submicron Polyethylene Particles on Periprosthetic Tissue in Rabbits. Sacoman D., Goodman S.B., Song Y., Fornasier V., Smith R.L., Stanford University Medical Center, Orthopaedic Research Laboratory, Stanford, USA. TISSUE ENGINEERING II Room 104A/B Chairs: K. Woodhouse, J. Hubbell 4:00: I-905. A Novel System for the Production of Chondrocyte Seeded Alginate Constructs. Enobakhare B.O., Bader D., Lee D.A., Institute of Orthopaedics, IRC in Biomedical Materials, Stanmore, UK. 4:15: I-906. Tissue-Specific Synthetic Bio-Textured Cell Adhesion Matrices. Goodman S.L., Sims P.A., Murphy C.J., Albrecht R.M., University of Wisconsin, Department AHABS, Madison, USA. 4:30: I-907. Two-Dimensional Manipulation of Confluent Cultured Cells. Kikuchi A., Okuhara M., Karikusa F., Sakai H., Sakurai Y., Okano T., Tokyo Women's Medical College, Institute of Biomedical Engineering, Tokyo, Japan. 4:45: I-908. Development of a Tissue Engineered Ligament Replacement. McTaggart S., Anderson M., Wolowacz S., Smith & Nephew Group Research Cntr, York, UK. 5:00: I-909. Growth of Osteoblasts on a Novel Blockcopolymer. Saad B., Matter S., Ciardelli G., Uhlschmid G.K., Welti M., Neuenschwander P., Suter U.W., ETH Zurich, Institute of Polymers, Zurich, Switzerland. 5:15: I-910. Cellular Response to Collogen/ Hyaluronic Acid Composites In-Vitro. Sabelman E., Koran P., Diep N., Lineaweaver W.C., VA Rehabilitation, R & D Center, Palo Alto, USA. ADHESIVES AND CEMENTS Room 104C Chairs: F.W. Cooke, E. Lautenschlager 4:00: I-911. Synthesis and Preclinical Evaluation of a Fast-Curing Bioresorbable Composite Bone Cement. Caywood G.A., Gunasekaran S., Kharas G.B., DynaGen Inc., Cambridge, USA. 4:15: I-912. Microencapsulated Radiopacifier for Bone Cements to Improve Fatigue Properties. Demian H.W., Shalaby S.W., Clemson University, Department of Bioengineering, Rockville, USA. 4:30: I-913. Fracture Toughness of Surface-Treated Carbon Fiber Reinforced Composite Bone Cement. Friis E.A., Kumar B., Cooke F.W., Yasuda H.K., Orthopaedic Research Institute Inc., Witchita, USA. 4:45: I-914. The Contribution of Pressurization to The Fatigue Resistance of Acrylic Bone Cement. Paravic V., Noble P.B., Alexander J.W., Liebs T.R., Elliot A., Baylor College of Medicine, Houston, USA. 5:00: I-915. Six Years Experience in Clinical Application of Ionomeric Bone Cements. Schmitz H.J., Laborde G., Zoellner W., Aachen University, Department of Oral/Maxillofacial, and Facial Surgery, Aachen, Germany. 5:15: I-916. Bending and Fracture Toughness of Woven Self-Reinforced Composite Poly(Methyl Methacrylate). Wright D.D., Lautenschlager E.P., Gilbert J.L., Northwestern Universtiy, Division of Biological Material, Chicago, USA. ORTHOP(r)DICS II Room 104D Chairs: J. Lemons, H.C. Amstatz 4:00: I-917. Established Competence of Bioactive Composite Bone Substitute on the Healing of Diaphyseal Segmental Defects in Sheep. Gao T.J., Lindholm T.S., Kommonen B., Lindholm T.C., University of Tampere, Institute of Technology, Tampere, Finland. 4:15: I-918. Cobalt and Chromium Concentrations in Patients with Metal-on-Metal Total Hip Replacements. Jacobs J.J., Skipor A.K., Doorn P.F., Campbell P., Schmalzried T.P., Black J., Amstutz H.C., Rush-Presbyterian-St. Luke's, Medical Center, Department of Orthopaedic Surgery, Chicago, USA. 4:30: I-919. Reconstruction of Mandibular Discontinuity Defects in Dogs Using Autogenic Particulate Cancellous Bone and Marrow and Poly(L-lactide) Mesh. Kinoshita Y., Kobayashi M., Ohtsuka T., Kuzuhara T., Yokoya S., Hukuoka S., Hidaka T., Kanagawa Dental College, Department of Oral & Maxillofacial, Surgery, Kanagawa, Japan. 4:45: I-920. A Novel Optical Technique to Characterize Intact Cortical Bone. Kovach I.S., Wang X., Agrawal C.M., Richards-Kortum R., Athanasiou K.A., University of Texas, Health Science Center, San Antonio, USA. 5:00: I-921. Modular Hip Stem Taper Corrosion: An Update. Levine D.L., Bhambri S., Gilbertson L.N., Shetty R., Zimmer Inc., Warsaw, USA. 5:15: I-922. Development Of Artificial Osteo- Chondral Composite Material. Oka M., Chang Y., Hyon S., Ikada Y., Cha W., Nakamura T., Kyoto University, Research Center for Biomedical, Engineering, Kyoto, Japan. ___________________________________________________________ Sunday, June 2: Keynote Session 8:30-9:00 Grand Ballroom 8:30 Keynote Lecture Larry Hench Interdisciplinary Research Centre in Biomedical Materials, Queen Mary and Westfield College, University of London, UKLondon, UK ÒMolecular Modelling of BiomaterialsÓ Chair: J. Michael Lee ___________________________________________________________ Sunday, June 2: Oral Session 10 9:00-10:30 DENTAL MATERIALS Room 206A/B Chairs: D. Smith, M. Braden 9:00: I-923. Spectroscopic Studies of Dentin and its Interface. Di Renzo M., Bakoyannis C., Ellis T., Sacher E., Stangel I., University of Montreal, Department de Chimie, Montreal, Canada. 9:15: I-924. AFM Imaging of the Etching of Human Dentin and Enamel. Ellis T.H., El Feninat F., Poulin S., Di Renzo M., Sacher E., Stangel I., University of Montreal, Department de Chimie, Montreal, Canada. 9:30: I-925. Periodontal Drug Delivery using Bioerodible Polymers. Gates K., Grad H., Birek P., Lee P.I., University of Toronto, Toronto, Canada. 9:45: I-926. ÒSmartÓ Fluoride-Releasing Restorative Materials. Kohn D.H., Carter B.F., Renier M.L., University of Michigan, School of Dentistry, Ann Arbor, USA. 10:00 I-927. Polymeric Dental Restorative Materials: In-Vitro Biodegradation by Cholesterol Esterase and Identification of Related Degradation Products. Shajii L., Tsang H., Santerre J., University of Toronto, Faculty of Dentistry, Department of Biomaterials, Toronto, Canada. 10:15 I-928. Experimental Study and Clinical Usage of Bioactive Material Lasozyme-Vita Paste in Pulp-Capping and Root Canal Therapy. Xi-jiu G., Zhong-fu Y., Panzhihua Municipal Central , Hospital, Department of Stomatology, China. BIOCOMPATIBILITY III Room 206D/C Chairs: L. Bjursten, J. Eaton 9:00: I-929. Osteoclast and Macrophage Responses to Artificially Produced Carbonate-Apatite Layers and Dentin. de Bruijn J., vd Brink I., Bovell Y.P., University of Leiden, Biomaterials Research Group, Bilthoven, Netherlands. 9:15: I-930. Interfacial Bond Hydrolytic Stability of Calcium Phosphate Fibers With Polycaprolactone Polymer. Foy K.E., Riddle Jr. D., Schutte Jr. H.D., Latour Jr. R.A., Clemson University, Department of Material Science &, Engineering, Clemson, USA. 9:30: I-931. Prevention of Post-Operative Adhesions By NÐOÐCarboxymethyl Chitosan. Kennedy R., McAlister A.C., Ciona C., Lee T.D.G., Dalhousie University, Department of Surgery, Halifax, Canada. 9:45: I-932. Lysosomal Enzyme Release from Neutrophils Adherent to Biomaterial Surfaces. Labow R.S., Erfle D.J., Santerre J.P., University of Ottawa , Heart Institute, Ottawa, Canada. 10:00 I-933. In-Vitro Evaluation of the Ability of a Phospholipid Polymer to Reduce Fibroblast Attachment. Newton B., Watanabe A., Iwasaki Y., Williams III P.F., Gilbert J.A., LaBerge M., Ishihara K., Mississippi State University, Department of Agriculture and Biological Engineering, USA. 10:15 I-934. Screening of Ionomericbone Bond for Hard Tissue Replacement. Schmitz H.J., Langer O., Arent J., Kornadt-Beck N., Aachen University, Department of Oral/Maxillofacial, and Facial Surgery, Aachen, Germany. CELL CULTURE Room 206E/F Chairs: M. Sigot, H. Sato 9:00: I-935. An In-Vitro Assay for Orthopaedic Biomaterials: The Interplay Between Cellular Source Biomaterials and Growth Factors. Howlett C., Chen T., Zreiqat H., McFarland C., Walsh W., University of New South Wales, School of Pathology, Bone Biomaterial Unit, Sydney, Australia. 9:15: I-936. In-Vitro Evaluation of Silanated Glasses as Model Surfaces for Monocyte/ Macrophage Adhesion and Foreign Body Giant Cell Formation. Jenney C.R., DeFife K.M., Colton E., Anderson J.M., Case Western University , Institute of Pathology, Dept. of Biomedical Engineering, Cleveland, USA. 9:30: I-937. Cell Interaction With Microtextured Surfaces. Ricci J.L., Rose R., Charvet J.K., Alexander H., Naiman C.S., Hospital for Joint Diseases, Department of Bioengineering, New York, USA. 9:45: I-938. Adhesion of Vascular Endothelial Cells on Fibrins Compared with Protein-Coated Artificial Materials. Sato H, Kyoto University, Dept. of Polymer Chemistry, Kyoto, Japan. 10:00 I-939. The Role of Protein Adsorption on Chondrocyte Adhesion to a Heterocyclic Methacrylate Polymer System. Sawtell R.M., Downes S., University of Nottingham, Quuen's Medical Centre, Department of Human Morphology, Nottingham, UK. 10:15 I-940. High Molecular Weight Kininogen Preadsorbed to Surfaces Markedly Reduces Leukocyte Adhesion. Yung L.Y.L., Lim F., Khan M.M.H., Kunapuli S.P., Rick L. , Colman R.W., Cooper S.L., University of Delaware, Department of Chemical Engineering, Newark, USA. BONE-SURFACE INTERACTIONS Room 104A/B Chairs: R. Bizios, S. Szmuckler 9:00: I-941. Surface Roughness Modulates the Response of MG63 Osteoblast-Like Cells to Vitamin D3 Stimulation. Boyan B.D., Batzer R., Liu Y., Schwartz Z., Cochran D., Dean D.D., Szmuckler S., University of Texas, Health Science Center , Department of Orthopaedics, San Antonio, USA. 9:15: I-942. Osteoclast-Like Cell Adhesion on Peptide-Modified Surfaces. Burkstrand M., Andersen T.T., Bizios R., Rensselaer Polytechnic Institute, Department of Biomedical Engineering, Troy, USA. 9:30: I-943. Effect of Titanium Roughness and BMP-2 Osteoblast Progenitor Cells In-Vitro. Cavin R., Ong J.L., Cardenas H.L., Carnes D.L., University of Texas, Health Science Center, Department of Restorative Materials, San Antonio, USA. 9:45: I-944. Surface Reaction Treatment Enhances Fibronectin-Mediated Osteoblast Attachment to Bioactive Glass In-Vitro. Garcia A.J., Ducheyne P., Boettiger D., University of Pennsylvania, Department of Bioengineering, Philadelphia, USA. 10:00 I-945. The Effects of Various Surface Treatment for Titanium on Primary Calcification. Itoh S., Takebe J., Ariake T., Ishibashi K., Iwate Medical University, Department of Fixed Prosthodontics, School of Dentistry, Morioka, Japan. 10:15 I-946. Preferential Mineralized Tissue Formation on Materials with Patterned Surface Chemistry. Thomas C.H., McFarland C.D., Gilbert J.L., Healy K.E., Northwestern Universtiy, Division of Biological Material, Chicago, USA. WEAR PARTICULATES II Room 104C Chairs: J. Medley, C. Agrawal 9:00: I-947. Particulate Debris Generated by Flexure of Transpedicular Spinal Implants. Doers T., Pienkowski D., Stephens G.C., Jacob R.J., Hamilton D.M., University of Kentucky, Division of Orthopaedic Surgery, Lexington, USA. 9:15: I-948. Raman Micro-Probe Analysis of Polyehtylene Wear Debris and Implant Surfaces: A Report on the Presence of b-Carotene. Hahn D.W., Wolfarth D.L., Parks N.L., Sandia National Laboratories, Livermore, USA. 9:30: I-949. Osteoblast and Macrophage Responses to Cobalt Chrome and Titanium Particles. Luchetti W.T., Gonzales J.B., Horowitz S.M., University of Pennsylvania, Department of Orthopaedic Surgery, Philadelphia, USA. 9:45: I-950. Effect of Hydroxyapatite on Polyethylene Particle-Induced Osteolysis. Ohashi H., Kobayashi A., Oonishi J., Iwaki H., Kadoya Y., Yutani Y., Yamano Y., Osaka City University, Medical School , Department of Orthopaedic Surgery, Osaka, Japan. 10:00 I-951. Tissue Response to Submicron Particles Implanted with a Press-Fit Tibial HemiArthroplasty in Rabbits. Protzner K., Fornasier V.L., Goodman S.B., Song Y., Shojaei A., The Wellesley Hospital, Department of Anatomic Pathology, & Cytology, Toronto, Canada. 10:15 I-952. Pathways for Particulate Debris in Cemented Total Hip Arthroplasties. Roberts E.B., Monroe W.T., Noble P.C., Paravic V., Feinstein W.K., Baylor College of Medicine, Houston, USA. TISSUE ENGINEERING III Room 104D Chairs: A.G. Mikos, D. Mooney 9:00: I-953. Supramolecular Assemblies - New Tools for the Modification of the Surfaces of Tissues and for Tissue Engineering. Elbert D.L., Herbert C.B., Hubbell J.A., California Institute of Technology, Division of Chemistry and, Chemical Engineering, Pasadena, USA. 9:15: I-954. Preparation of Heterofunctional Nanoparticles Whose Surfaces Serve Both DNA Adsorption Sites and Sugar-Specific Recognition Sites. Ishihara T., Maruyama A., Akaike T., Kim S.W., Tokyo Institute of Technology, Dept. of Biomolecular Engineering, Faculty of Bioscience & Technology, Yokohama-shi, Japan. 9:30: I-955. Engineering Dental Pulp Tissue. Mooney D., Powell C., Piana J., Rutherford R., University of Michigan, Dental and Engineering Schools, Ann Arbor, USA. 9:45: I-956. Encapsulation of Chemically Modified Hemoglobin Reduces Vasoconstrictor Activity in Isolated Rabbit Vessel Segments. Rudolph A., Sulpezio T., Heible P., MacDonald V., Feuerstein G., Code 6910 Naval Research Lab, Center for Biomolecular Science, and Engineering, Washington, USA. 10:00 I-957. Promising Application of a Super Biomatrix (PVLA) for Hybrid Artificial Liver - Switching of EGF Signals by Regulating Hepatocyte Morphology. Takei R., Watanabe Y., Kobayashi K., Kobayashi A., Akaike T., Tokyo Institute of Technology, Dept of Biomolecular Engineering, Faculty of Bioscience & Technology, Yokohama-shi, Japan. 10:15 I-958. Pliable Degradable Polymer Foams to Engineer Soft Tissues. Wake M.C., Gupta P.K., Mikos A.G., Rice University, Department of Chemical Engineering, Institute of Biosciences and Bioeng., Houston, USA. ___________________________________________________________ Sunday, June 2: Oral Session 11 11:00-12:30 SURFACE MODIFICATION: METALS Room 206A/B Chairs: R. Pilliar, P. Ducheyne 11:00 I-959. Formation of Chromium (VI) During Coating of Steel with Glass. Andersson O.H., Hero H., Turku Centre for Biomaterials, Lemminkaisenkatu, Turku, Finland. 11:15 I-960. Surface Modification of Metallic Biomaterials Using Corrosion-Resistant Cr-B Thin Films. Cormier L.M., Pilliar R.M., Thorpe S.J., University of Toronto, Centre for Biomaterials, Toronto, Canada. 11:30 I-961. Bioactive Titanium Metals Prepared via Simple Chemical Process. Miyaji F., Kim H.M., Kokubo T., Nakamura T., Kyoto University, Faculty of Engineering, Department of Material Chemistry, Kyoto, Japan. 11:45 I-962. Retention of Enzymatic Activity Immobilized on Silanized Co-Cr-Mo and Ti-6Al-4V. Puleo D.A., University of Kentucky, Center for Biomedical Engineering, Lexington, USA. 12:00 I-963. Nanocrystalline Hard Coatings for Orthopaedic Bearing Surfaces. Tobin E., Karimy H., Namavar F., Sioshansi P., Spire Corporation, Bedford, USA. 12:15 I-964. Surface Characterization of Calcium- Ion-Mixing Treated Titanium in Electrolyte. Ukai H., Murakami K., Hanawa T., Asaoka K., Tokushima University, Tokyo, Japan. OPHTHALMOLOGY Room 206C/D Chairs: E. Goldberg, P. Dalton 11:00 I-965. Epithelial Cell Attachment to Collagen- Based Lenses. DeVore D.P., Skelnik D., Kornmehl E.W., Collagenesis Inc., Acton, USA. 11:15 I-966. Reduction of Collagenase Activity Associated with Keratoprosthesis Materials. Fitton J.H., Hicks C.R., Ziegelaar B.W., Clayton T., Chirila T.V., Dalton P.D., Constable I.J., Lions Eye Institute, Perth, Australia. 11:30 I-967. Interactions of Collagen with PVSA and PSSA. Giusti P., Lazzeri L., Cristallini C., Barbani N., Cascone M.G., Polacco G., Pizziranni G., University of Pisa, Department of Chemical Engineering, Pisa, Italy. 11:45 I-968. Biocompatibility Response to Modified Baerveldt Glaucoma Drains. Jacob-Labarre J.T., McKinnon S.J., Tanji T., LSU Eye Center, New Orleans, USA. 12:00 I-969. Plasma Surface Modification of Artificial Corneas for Optimal Epithelialization. Sheu M.S., Loh I.H., Latkany R., Tsuk A., Trinkaus-Randall V., Advanced Surface Technology, Billerica, USA. LOAD-BEARING MATERIALS Room 206E/F Chairs: W.M. Sanford, H.J. Rack 11:00 I-970. Wear Of UHMWPE Acetabular Cups in a Physiological Hip Joint Simulator In The Anatomical Position. Bigsby R., Hardaker C.S., Fisher J., University of Leeds, Dept. of Mechanical, Engineering, Leeds, UK. 11:15 I-971. Comparison of the Wear of Aged and Non-Aged Ultrahigh Molecular Weight Polyethylene Sterilised by Gamma Irradiation and by Gas Plasma. Fisher J., Reeves E.A., Isaac G.H., Saum K.A., Sanford W.M., University of Leeds, Department of Mechanical Engineering, Leeds, UK. 11:30 I-972. The Effect of Oxidation and Nonconsolidated Polyethylene Particles on the Wear of Retrieved Acetabular Cups. Li S., Barrena E.G., Furman B.D., Wright T.M., Salvati E.A., Hospital for Special Surgery, Biomechanics, New York, USA. 11:45 I-974. Characterization of Composite Material Based on Biphasic Calcium Phosphate-Polymer Mixture. Nguyen T., Dupraz A., Institut des Materiaux de Nantes, Nantes, France. 12:00 I-975. Processing and Mechanical Testing of Hydroxyapatite/Zirconium Oxide Composites for Load Bearing Applications. Towler M.R., Varma H.K., Best S.M., Bonfield W., University of London, Queen Mary & Westfield College, IRC in Biomedical Materials, London, UK. 12:15 I-973. Ultrasonic Method for In-Situ Continuous Wear Measurements of Orthopaedic Titanium Alloys. Long M., Rack H.J., Clemson University, School of Chemical And Materials Eng., Bioengineering Dept., Clemson, USA. [*Withdrawn*] BONE GROWTH Room 104A/B Chairs: R. Albrektsson, H. Oligushi 11:00 I-976. Cell Contact is Required to Potentiate Bone Growth in the Presence of Bioactive Glasses. Davies J.E., Shen X., Zhong J., Greenspan D.C., University of Toronto, Centre for Biomaterials, Toronto, Canada. 11:15 I-977. Bone Ingrowth in Solvent Dehydrated Bone Transplants and Ceramics. Guenther K.P., Scharf H.P., Pesch H.J., University of Ulm, Department Orthopaedic Surgery, Ulm, Germany. 11:30 I-978. Guided Bone Regeneration Around Dental Implants in the Atrophic Alveolar Ridge Using a Bioresorbable Device - An Experimental Study in the Monkey. Hurzeler M.B., Hutmacher D., Albert-Ludwigs University, Department of Biomechanics and , Biomaterials, Freiburg, Germany. 11:45 I-979. Three Dimensional In-Vitro Mechanical Model for Bone Formation. Jen A.C., Ishaug S.L., Yaszemski M.J., McIntire L.V., Mikos A.G., Rice University, Institute of Biosciences and, Bioengineering, Houston, USA. 12:00 I-980. The Role of Serum Glycoproteins in Determining the Spatial Organisation of Bone Cells on Patterned Surfaces. McFarland C.D., Thomas C.H., Healy K.E., Jenkins M.L., Steele J.G., CSIRO, Division of Biomolecular Engineering, North Ryde, Australia. 12:15 I-981. Osteogenic Effects Produced by Collagen Matrices Evaluated in the Rat Parietal Bone Defect Model: Histological and Morphometric Observations. Schroeder-Tefft J.A., Bentz H., Wilson F.D., Collagen Corporation, Palo Alto, USA. POLYETHYLENE II Room 104C Chairs: T. Bryant, E.L. Thomas 11:00 I-982. Characterization of Wear Surface and Bulk Morphology of Retrieved Hylamer Acetabular Cups. Bellare A., Livingston B.J., Cohen R.E., Chmell M., Thomas W., Poss R., Sledge C., Brigham and Women's Hospital, Department of Orthopaedic Surgery, Boston, USA. 11:15 I-983. Near Surface Morphology of UHMWPE Tibial Inserts. Carvalho B.L., Thomas E.L., MIT, Department of Materials Science, & Engineering, Cambridge, USA. 11:30 I-984. The Role of Kinematic Condition on the Wear of UHMWPE. Cornwall G.B., Hansson C.M., Bowe A.J., Bryant J.T., Queen's University, Department of Mechanical, Engineering, Kingston, Canada. 11:45 I-985. Prediction of Long-Term Creep Behavior of Ultrahigh Molecular Weight Polyethylene. Deng M., Latour Jr. R.A., Ogale A.A., Shalaby S.W., Clemson University, Department of Bioengineering, Pendleton, USA. 12:00 I-986. The Role of Incomplete Fusion of UHMWPE Powder: Mechanical and Chemical Degradation of Total Joint Arthroplasties. Dwyer K.A., Bryant J.T., Queen's University, Department of Mechanical, Engineering, Kingston, Canada. 12:15 I-987. Dynamic Compressive Creep of Extruded Ultrahigh Molecular Weight Polyethylene. Lee K.Y., Pienkowski D., University of Kentucky, Division of Orthopaedic Surgery, Lexington, USA. TISSUE ENGINEERING IV Room 104D Chairs: G. Picciolo, K.W. Leung 11:00 I-988. A Novel Encapsulation Membrane for Studying Embryonic Tissue Grafted into the Central Nervous System. Broadhead K.W., LeSauter J., Silver R., Tresco P.A., University of Utah, Department of Bioengineering, Tissue Engineering Laboratory, Salt Lake City, USA. 11:15 I-989. The Surface Modification and Characterization of Poly(Lactic Acid-Co- Lysine) with Covalently Attached RGD- Containing Peptides. Cook A.D., Johnson I.M., Pajvani U.B., Liu Y., Dong X.D., Langer R., Massachusetts Institute of Technology, Department of Chemical Engineering, Cambridge, USA. 11:30 I-990. Tethered Growth Factors Elicit Mitogenic Responses in Cultured Hepatocytes. Griffith-Cima L.G., Kuhl P.R., MIT, Department of Chemical Engineering, Cambridge, USA. 11:45 I-991. Biodegradable Ligand-Immobilizable and Biocompatible Lactide-Based PEG Polymer Networks for Tissue Engineering. Han D.K., Kim Y.H., Hubbell J.A., California Institute of Technology, Division of Chemistry and, Chemical Engineering, Pasadena, USA. 12:00 I-992. Modification of Glass for Controlled Nerve Cell Interaction. Shoichet M.S., Kerba C.P., Pennefather P.S., University of Toronto, Department of Chemical Engineering, and Applied Chemistry, Toronto, Canada. ___________________________________________________________ CLOSURE ___________________________________________________________